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Autonomics > Cholinomimetics > Flashcards

Cholinomimetics Flashcards

1
Q

Bethanechol

A

Class: Direct acting carbamic acid ester

Mechanism: Direct-acting muscarinic cholinomimetic

Therapeutics: Post-operative and neurogenic ileus; urinary retention (bowel and bladder smooth muscle ACh-innervated)

Side Effects: SLUDGE

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2
Q

Muscarine

A

Class: Direct acting non-ester alkaloid
Mechanism:Direct-acting muscarinic cholinomimetic
Side Effects: SLUDGE

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3
Q

Pilocarpine (Salagen)

A

Class: Direct acting non-ester alkaloid
Mechanism: Direct-acting muscarinic cholinomimetic
Therapeutics: Glaucoma (ACh activates papillary sphincter and ciliary muscles of eye)
Side Effects: SLUDGE

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4
Q

Cevimeline (Evoxac)

A

Class: Direct acting non-ester alkaloid
Mechanism: Direct-acting muscarinic cholinomimetic
Therapeutics: Dry mouth (in, e.g., Sjogren’s, post-radiation therapy; via increased salivation)
Side Effects: SLUDGE

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5
Q

Nicotine (NRT)

A

Class: Direct acting non-ester alkaloid
Mechanism: Direct-acting nicotinic cholinomimetic
Therapeutics: Smoking cessation (reduces cravings)

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6
Q

Neostigmine (Prostigmin)

A

Class: Indirect acting carbamate
Mechanism: AChE inhibitor (short acting)
Therapeutics: Post-operative and neurogenic ileus; urinary retention; myasthenia gravis; reversal of neuromuscular blockade
Side Effects: SLUDGE + general increase in cholinergic neurotransmission; paralysis

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7
Q

Physostigmine (Eserine)

A

Class: Indirect acting carbamate
Mechanism: AChE inhibitor (short acting)
Therapeutics: Glaucoma (ACh activates papillary sphincter and ciliary muscles of eye)
Side Effects: SLUDGE + general increase in cholinergic neurotransmission; paralysis

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8
Q

Donepezil (Aricept)

A

Class: Indirect acting non-ester
Mechanism: AChE inhibitor
Therapeutics: Alzheimer’s (amplifies endogenous ACh in brain)
Side Effects: SLUDGE + general increase in cholinergic neurotransmission; paralysis

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9
Q

Edrophonium (Enlon)

A

Class:Indirect acting non-ester
Mechanism:AChE inhibitor (v. short acting)
Therapeutics: Myasthenia gravis (differentiating deficiency versus ACh crisis); ileus
Side Effects: SLUDGE + general increase in cholinergic neurotransmission; paralysis

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10
Q

Echothiophate (Phospholine)

A

Class: Indirect acting organophosphate
Mechanism: AChE inhibitor (long acting)
Therapeutics: Glaucoma (ACh activates papillary sphincter and ciliary muscles of eye)
Side Effects: SLUDGE + general increase in cholinergic neurotransmission; paralysis

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11
Q

Pralidoxime (Protopam)

A

Class:Strong nucleophile
Mechanism: Regenerates phosphorylated AChE
Therapeutics: Poisoning by nerve gas, insecticide

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Autonomics (10 decks)

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