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Autonomics > Adrenergic > Flashcards

Adrenergic Flashcards

1
Q

Norepinephrine (Levophed)

A

Class: Non-selective agonist
Mechanism: Agonist: α1, α2, β1
Therapeutics: Hypotension
Side Effects: Hypertension; arrythmias; headache

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2
Q

Epinephrine

A

Class: Non-selective agonist
Mechanism: Agonist: α1, (α2), β1, β2
Therapeutics: Anaphylactic shock; combined with local anesthetics; glaucoma
Side Effects: Palpitation; arrhythmias; headache; tremor

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3
Q

Amphetamine

A

Class: Indirect acting
Mechanism: Increases release of NE
Therapeutics: ADHD, narcolepsy, recreation
Side Effects: Hypertension, insomnia, anxiety, arrhythmias

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4
Q

Isoproterenol (Isuprel)

A

Class: Non-selective β agonist
Mechanism: Agonist: β1, β2
Therapeutics: Bronchodilator/asthma; shock; heart block
Side Effects: Palpitation; tachyarrhythmia; headache

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5
Q

Dobutamine

A

Class: β1-selective β agonist
Mechanism: Agonist: β1
Therapeutics: Cardiac decompensation; shock; heart block
Side Effects: Tachyarrythmias; hypertension

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6
Q

Albuterol (Proventil)

A

Class: β2-selective β agonist
Mechanism: Brochodilation
Therapeutics: Prevent or reverse exercise-induced bronchospasm; mild asthma; COPD
Side Effects: Can mask progressively severe inflammation

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7
Q

Terbutaline (Brethine)

A

Class: β2-selective β agonist
Mechanism: Brochodilation
Therapeutics: Prevent or reverse exercise-induced bronchospasm; mild asthma; COPD; early labor
Side Effects: Can mask progressively severe inflammation

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8
Q

Phenylephrine (Neo-Synephrine)

A

Class: α1-selective α agonist
Mechanism: Vasoconstriction
Therapeutics: Nasal congestion; postural Hypotension
Side Effects: Hypertension; reflex bradycardia

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9
Q

Clonidine (Catapres)

A

Class: α2-selective α agonist
Mechanism: Decrease sympathetic outflow from CNS
Therapeutics: Hypertension; shock; withdrawal from drug dependence
Side Effects: Sedation

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10
Q

α-methyldopa (Aldomet)

A

Class: α2-selective α agonist
Mechanism: Decreases synthesis of NE (by going through entire pathway instead of dopa); end-product (a-methylnorepinephrine) activates a2 inhibitors
Therapeutics: Hypertension, shock, withdrawal from drug dependence
Side Effects: Sedation

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11
Q

Fenoldopam (Corlopam)

A

Class: Selective dopamine agonist
Mechanism: Vasodilation
Therapeutics: Increase blood flow at renal, mesenteric, and cerebral arteries

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12
Q

Dopamine

A

Class: Mixed acting (direct/indirect)
Mechanism: Agonist: D1, α1, β1
Therapeutics: Shock, renal failure, hypotension
Side Effects: Vasoconstriction (@ high doses)

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13
Q

Phentolamine (Regitine)

A

Class: Non-selective α-antagonist
Mechanism: Antagonist: α1, α2
Therapeutics: Pheochromocytoma, Raynaud’s, frostbite
Side Effects: Postural hypotension; inhibit ejaculation

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14
Q

Phenoxybenzamine (Dibenzyline)

A

Class: Non-selective α-antagonist
Mechanism: Antagonist: α1, α2; non-competitive blocker (covalent bond to receptor)
Therapeutics: Pheochromocytoma, Raynaud’s, frostbite
Side Effects: Postural hypotension; inhibit ejaculation

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15
Q

Prazosin (Minipress)

A

Class: α1-selective antagonist
Mechanism: Vasodilation
Therapeutics: Primary HTN, BPH
Side Effects: Postural hypotension (usually 1st dose)

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16
Q

Terazosin (Hytrin)

A

Class: α1-selective antagonist
Mechanism: Vasodilation
Therapeutics: Primary HTN, BPH
Side Effects: Postural hypotension (usually 1st dose)

17
Q

Propranolol (Inderal)

A

Class: Non-selective β-antagonist (1st generation)
Mechanism: Antagonist: β1, β2
Therapeutics: Angina, Hypertension, Arrythmias
Side Effects: Bradycardia, Bronchoconstriction, Sexual Dysfunction

18
Q

Timolol (Betimol)

A

Class: Non-selective β-antagonist (1st generation)
Mechanism: Antagonist: β1, β2
Therapeutics: Angina, Hypertension, Arrythmias, Glaucoma
Side Effects: Bradycardia, Bronchoconstriction, Sexual Dysfunction

19
Q

Metoprolol (Lopressor)

A

Class: β1-selective antagonist (2nd generation)
Mechanism: Decrease heart rate, contractility, CO
Therapeutics: HTN, Angina, Arrythmias, CHF
Side Effects: Bradycardia, Sexual Dysfunction

20
Q

Atenolol (Tenormin)

A

Class: β1-selective antagonist (2nd generation)
Mechanism: Decrease heart rate, contractility, CO
Therapeutics: HTN, Angina, Arrythmias, CHF
Side Effects: Bradycardia, Sexual Dysfunction

21
Q

Bisoprolol (Zebeta)

A

Class: β1-selective antagonist (2nd generation)
Mechanism: Decrease heart rate, contractility, CO
Therapeutics: HTN, Angina, Arrythmias, CHF
Side Effects: Bradycardia, Sexual Dysfunction

22
Q

Carvedilol (Coreg)

A

Class: Non-selective β-antagonist (3rd generation “A”)
Mechanism: Antagonist: β1, β2
Therapeutics: CHF, HTN
Side Effects: Bradycardia, Fatigue

23
Q

Labetalol (Trandate)

A

Class: Non-selective β-antagonist (3rd generation “A”)
Mechanism: Antagonist: β1, β2
Therapeutics: CHF, HTN
Side Effects: Bradycardia, Fatigue

24
Q

Betaxolol (Kerlone)

A

Class: β1-selective antagonist (3rd generation “B”)
Mechanism: Decrease heart rate, CO
Therapeutics: CHF, HTN
Side Effects: Bradycardia

25
Q

Tyramine

A

Class: Indirect acting
Mechanism: Increases cytoplasmic NE release
Misc: Tyramine is involved with an exchange transporter: tyramine goes in, NE comes out

26
Q

Guanethidine (Ismelin)

A

Mechanism: False neurotransmitter (vesicles become full of guanethidine rather than NE)
Therapeutics: Antihypertensive
Side Effects: Many and serious

27
Q

Reserpine

A

Mechanism: Release of empty vesicles (NE is not taken into vesicles b/c it binds uptake transporter and stops it)
Therapeutics: Older antihypertensive
Side Effects: Many and serious (depression and suicide are major ones)

28
Q

α-me-tyrosine (Metirosine)

A

Mechanism: Inhibit tyrosine hydroxylase (decreases NE synthesis)
Therapeutics: Pheochromocytoma
Side Effects: Many and serious

29
Q

Ephedrine (Pretz-D)

A

Therapeutics: Nasal decongestion, anorexic

Autonomics (10 decks)

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