Cholinergic mexhanism

Question 1

Semisynthetic conjugate of Anisotropine

Answer 1

Clinidium

Question 2

Synthetic conjugate of Glycopyrrolate

Answer 2

Dicyclomine

Question 3

Synthetic conjugate of Homatropine

Answer 3

Hexocyclium

Question 4

Semisynthetic conjugate of ipatropium

Answer 4

Isopropamide

Question 5

Synthetic conjugate of propantheline

Answer 5

Oxybutynin

Question 6

Semisynthetic conjugate of tolterodine

Answer 6

Tridihexethyl

Question 7

Antihistamines are known to antagonize cholinergic agents T/F

Answer 7

T

Question 8

Natural group of alkaloids

Answer 8

1. Atropine
2. Scopolamine

Question 9

Small diesel if cholinergic antagonists cause

Answer 9

Decreased heart rate
Decreased tremors

Question 10

Large doses of cholinergic antagonists cause

Answer 10

1. Increased heart rate
2. Drowsiness, hallucinations, Dilated pupils (mydriasis)

Question 11

Cholinergic antagonists are used in the treatment of Parkinson’s disease by

Answer 11

Decreasing muscle rigidity
Decreasing power tremors

Question 12

Atropine is used primarily for

Answer 12

Cardiovascular disorders

Question 13

Cholinergic antagonists are used to treat (respiratory)

Answer 13

Chronic bronchitis
Asthma

Question 14

Cholinergic antagonists are used to treat (gastrointestinal/urinal)

Answer 14

Peptic ulcer
Irritable bowel disease
GI hypersecretory states

Question 15

Choline esters act at all sites, like acetylcholine but are resistant to degradation by

Answer 15

ACETYLCHOLINESTERASES

Question 16

Functional groups that make up Acetycholine

Answer 16

Acyl group
Ethylene Bridge
Omium group

Question 17

What groups can be substituted into the acyl group to form a more potent compound

Answer 17

Primary amine
Ether/Ketone
Aromatic

Question 18

Modifications of ethylene bridge

Answer 18

1. Replacement of H with methyl group increases cholinergic activity (with larger group than methyl decreases activity)
2. Substitution of methyl group at beta carbon acts selectively on muscarinic receptors

Question 19

Modifications in omium group

Answer 19

1. Primary,Secondary and Tertiary amines are less active than quaternary amines
2. If methyl group is replaced by ethyl group or larger ethyl group it produces INACTIVE compounds
3. Nitrogen can be replaced by arsenic, antimony, phosphorus or sulphur atom