Cholinergic antagonist (GEM) Flashcards
Natural anti-muscarinic drugs
Atropine
Scopolamine
Semi synthetic muscarinic drugs
Homatropine
Atropine meth-nitrate
Hyoscine butyl-bromide
Synthetic anti-muscarinic drugs
Tiotropium
Ipratropium
Tropicamide
Tolterodine
Solifenacin
Benztropine
Oxybutynin
Trihexyphenidyl
Cyclopentolate
NOT ALL THE ANSWERS
Non-depolarizing ganglionic anti-nicotinics
Hexamethonium
Mecamylamine
Trimethaphan
Pentolinium
Pempidine
Benzohexonium
Chlorisondiamine
Depolarizing ganglionic anti nicotinics
Nicotine (high dose)
Organophosphate (high dose)
Depolarizing NMJ anti-nicotinics
Suxamethonium
Decamethonium
Non-depolarizing NMJ anti-nicotinics (long-acting)
–Tubocurarine
–Pancuronium
–Doxacurium
–Pipecuronium
Non-depolarizing NMJ anti-nicotinics (intermediate acting)
–Vecuronium
–Rocuronium
–Cis-atracurium
–Atracurium
Non NMJ mid CARV
Non-depolarizing NMJ anti-nicotinics (short acting)
Mivacurium
Indications of anti-muscarinic drugs
•Overactive Bladder Syndrome
•Irritable Bowel Syndrome
•Diarrhea
•Motion sickness
•Peptic ulcer
•Uveitis
•COPD
•Asthma
•Extrapyramidal Symptoms of Anti-Psychotics/Parkinsonism
•Sinus Bradycardia
•Mydriatics & Cyclopegics
•Anticholinesterase poisoning
Indications of anti-nicotinic drugs
INDICATIONS
ANTI-NICOTINIC DRUGS
•Muscle relaxant in anesthesia
•Antitussives
Adverse effects of cholinergic antagonists
ADVERSE EFFECT
•Hyperthermia
•Tachycardia
•Xerostomia
•Flushed skin
•Hallucination
•Confusion
•Constipation
•Urinary retention
•Mydriasis
•Cycloplegia
Contraindication of cholinergic antagonists
CONTRAINDICATION
•Tachyarrhythmia
•Heart failure
•Myocardial infarction
•Hyperthyroidism
•Obstructive Gastropathy
•Obstructive Uropathy
•Glaucoma
•Myasthenia gravis
•Paralytic ileus
•Hiatal hernia
