Cholinergic Drugs

Question 1

two general types of Cholinergic Drugs?

Answer 1

Direct Acting, Indirect Acting

Question 2

Direct Acting cholinergic drugs do what?

Answer 2

act directly on muscarinic receptors

Question 3

Indirect Acting cholinergic drugs do what?

Answer 3

inhibit Acetylcholinesterase (AChE)

Question 4

indications for Cholinergic Drugs

Answer 4

glaucoma, GI disorders (paralytic ileus), urinary retention, Alzheimer’s, diagnosis of myasthenia gravis

Question 5

what is Alzheimer’s Disease associated with?

Answer 5

decreased levels of Ach

Question 6

general MOA of Alzheimer’s drugs

Answer 6

reversibly bind AChE so it does not break down ACh (indirect acting)

Question 7

AE of Alzheimer’s drugs

Answer 7

varies but mostly GI (N/V/D)

Question 8

Cholinergic drugs will do what?

Answer 8

enhance the PNS (increase secretions)

Question 9

Cholingeric AE

Answer 9

SLUDGE or DUMBELLS

Question 10

what does SLUDGE stand for?

Answer 10

Sweating, 
Lacrimation, 
Urination, 
Diarrhea, 
GI cramping, 
Emesis (vomiting)

Question 11

What does DUMBELLS stand for?

Answer 11

Diarrhea, 
Urination, 
Miosis, 
Bradycardia, 
Emesis, 
Lacrimation, 
Lethargy, 
Salivation/Sweating

Question 12

who should avoid Cholinergic drugs?

Answer 12

ppl w/history of COPD or asthma, urinary tract obstruction, Parkinson’s, Peptic ulcer disease (PUD)

Question 13

Therapeutic Concerns for Direct/Indirect acting muscarinic agents?

Answer 13

CV effects (bradycardia, decreased CO, syncope, hypotension), GI issues, bronchoconstriction, frequent urination, increased secretions

Question 14

Atropine AE

Answer 14

low doses: dry mouth,

high doses: blurred vision, hallucinations, confusion, coma

Question 15

other Atropine AE

Answer 15

tachycardia, decreased bronchial secretions, constipation, urinary retention