Anticholinergic Drugs

Question 1

broad function of anticholinergic drugs?

Answer 1

suppress PNS

Question 2

Key AE of anticholinergic drugs

Answer 2

ABCDs

Question 3

what does ABCDs stand for?

Answer 3

agitation, blurred vision, constipation/confusion, dry mouth, stasis or urine and sweat

Question 4

when should an anticholinergic drug be avoided?

Answer 4

1) . history of urinary retention,

2) . narrow angle closure glaucoma

Question 5

what are some indications for anticholinergic drugs?

Answer 5

COPD, asthma, Parkinson’s, OAB, motion sickness, decreasing saliva/secretions pre-surgery, treating poisoning, opthalmic exams

Question 6

Atropine indications

Answer 6

1) . decrease saliva/secretions pre-surgery,

2) . treat poisoning

Question 7

MOA of anticholinergic drugs that treat OAB

Answer 7

antagonize muscarinic receptors on bladder smooth muscle => decrease contractions

Question 8

general MOA of 1st gen antihistamines

Answer 8

bind histamine receptors in periphery and CNS = more sedation

Question 9

general MOA of 2nd gen antihistamines

Answer 9

less muscarinic receptor binding = less anticholinergic effects

Question 10

general MOA of antidepressants

Answer 10

primarily increases serotonin and NE; H1 antagonists (sedating) and muscarinic antagonists

Question 11

anticholinergic drug that is an antidepressant

Answer 11

TCA (tricyclic antidepressants)

Question 12

What is the Beers List?

Answer 12

list of potentially inappropriate meds on older adults

Question 13

drugs on Beers list may worsen what symptoms?

Answer 13

delirium, CNS-effect (confusion), urinary retention