Cholinergic Drugs

Question 1

Major Types of Cholinoceptors

Answer 1

Nicotinic- Ligand gated ionotropic Channel

Muscarinic- Metabotropic Channel

Acetylcholine is the endogenous ligand for both receptors

Question 2

Length of preganglionic neurons in SYMP vs PARA

Answer 2

PARA: long preganglionic neuron (ganglia near target)

SYMP: short preganglionic neurons (ganglia near spinal cord)

Question 3

What is the primary postganglionic neurotransmitter in PARASYMPATHETIC

Answer 3

Acetylcholine

Question 4

What Neurotransmitter is used with both SYMPATHETIC and PARASYMPATHETIC Preganglionic neurons

Answer 4

Acetylcholine

Question 5

Acetylcholinesterase inhibitors

Answer 5

USed to decrease the breakdown of acetylcholine to keep it around and active

Question 6

Signs of muscarinic excess

Answer 6

Mitosis, salivation, sweating, bronchiconstriction, Diarrhea

Question 7

Signs of nicotinic excess

Answer 7

Cognitive disturbance, convulsions, coma

Question 8

Treatment for ingesting insecticide

Answer 8

ATROPINE (Muscarinic antagonist)

Also pralidoxine if you catch it fast enough