Chlamydia Flashcards
Pneumoniae
Human Horse Koala Multisystem Reptile Amphibians
Pecorum
Ruminants
Pigs
Koala
Multisystem
Caviae
Guinea pig conjunctivitis/pneumonitis
Psittaci
Avian resp disease
Zoonotic
Abortus
Ruminant abortion
Zoonotic
Felis
Cat conjunctivitis and rhinitis
Trachomatis
Human ocular and urogenital
Muridarum
Mouse resp and urogenital
Suis
Porcine pneumonia
Enteritis
Conjunctivitis
Chlamydia description
Obligate IC
G-ve
Trachomatis genital tract infections incubation period and symptoms
Incubation 7-14d
Pain on discharge or urine can last a few days,
Many asymptomatic
Genital chlamydia conseq
Persistance can cause immpath and irreversible tissue dam
Pelvic inflam disease and infertility
Ectopic pregnancy
Risk factor for persistant oncogenic HPV
Genital chlamydia infection type and treatment
Persistent/chronic with re-infection common
Disease caused by immpath
Treated with antibio no vacc
Elementary body
Infective stage
Spore like
Res to enviro stress
Can’t multiply
Reticulate body
Non infective
Replication stage i. Host cell
Chlamydia pathogenesis
EB Adhere to CM Endocytosis and remain in vacuole Prev lysosome-phagosome fusion EB to RB transformation Division to form an inclusion Differentiate to EB Host cell lysis
Trachomatis ocular infection
Leading cause of preventable blindness
Infection starts in childhood and is persistent
Pneumoniae causes
Acute resp infections (horse koala human reptile amphibian)
Most mild but can be severe
Role in chronic inflam lung disease and putative links with coronary heart disease
Mouse models
Muridarum model for human genital tract and lung infection
Caviae model for genital tract and maybe ocular infection
Suis causes
Common pig infection assoc with asympt GI infection also conjunctivitis pneumonia pericarditis and repro disorders
tetracycline res strains exist
Psittici causes
Clinical signs often diarrhoea anorexia resp distress sinusitis rhinitis conjunctivitis
Parrots game birds pigeons poultry
Zoonotic assoc with resp infections
Felis causes
Conjunctivitis and rhinitis in cats esp kittens, rarely zoonotic
Vacc for cats exists
Pecorum causes
Enteritis conjunctivitis pneumonia polyarthritis ecephalomyelitis metritis mastitis
Ruminants pigs koalas other marsupials
Most common of sheep can complicate EAE diagnosis
Koalas cause keratoconjunctivitis (blindness) UTIs and GTI
Abortus causes
OEA and EAE
Leading diagnosed cause of abortion in sheep rarely abort more than once due to it
Usually causes late abortions and still births or weak offspring
Fetus isnt necrotic but placenta often inflamed with visible lesions and covered with exudate
EB can be Giesma stained from placenta or vaginal discharge
What happens if abortus contracted in diff gestation stages
During early - abort late in gest
Outwith gest - abort towards end of next one
Abortus pathogenesis
Ingestion or inhalation
Localisation to tonsils/lymph nodes
Dissemination
Latent, persistent or intermittent infection
Placentitis
Foetal infection
Abortion/still birth/weak or sub clinically infected lambs
