Childhood psychiatric disorders (including pharm)

Question 1

Methylphenidate

Answer 1

For ADHD

• increases DA for presynaptic terminal
• short onset
• long acting

Question 2

Amphetamine for ADHD mech

Answer 2

• increase release of DA and NE from synaptic terminal

- short acting

Question 3

Non-stimulants to tx ADHD

-contraindications

Answer 3

1. Atomoxetine -> NE reuptake inhibitor
2. Bupropion -> blocks DA and NE reuptake
   - lower seizure threshold
   - contraindicated in eating disorders
3. Clonidine/guanfacine
   - alpha-2 agonist
   - guanfacine is specific to alpha 2 A
   - decrease synaptic release of NE and DA
   - other effects at glutamatergic neurons
   - differential effects in thalamic NE neurons