Chest medicine Flashcards
Commonest cause of pneumonia?
Steptococcus pneumoniae
Chlamidophila psittaci, how would you contract this bacteria?
Birds, this is a zoonosis
CURB-65 breakdown?
C - confusion U - urea >7mmol/L R - resp rate >30/min B - BP (sys <60) Age - greater than 65
SARS - what type of pathogen is it?
Coronavirus
Atypical cause of pneumonia in HIV +ve patients with CD4 less than 200/mm3?
Pneumocystis pneumonia caused by Pneumocystis jiroveci
Common causes of HAP?
G-ve bacteria (E coli & P aerunginosa) 50%
Staph aureus 20%
Strep pneumoniae 15%
Typical features?
Cough, purulent sputum, fever with pleuritic chest pain and breathlessness
Localised chest signs: crackles, dullness, bronchial breathing
Resp failure indicated by cyanosis and tachypnoea
Investigations?
CXR - consolodation
Haematology and biochem tests
Pulse oximetry & ABG
Sputum gram stain
Sputum culture
Blood culture
Pleural fluid aspiration
Antibiotics in CAP and HAP?
CAP - amoxicillin (plus clarithromycin if atypical)
HAP - aminoglycacide and 3rd gen cephlasporin
What is ARDS?
a form of acute respiratory failure by PULMONARY OEDEMA
resulting from ENDOTHELIAL DAMAGE
due to a cascade of INFLAMATORY EVENTS
developing in responce to an INTIATING INJURY/ILLNESS
ARDS - pathogensis?
Usually pulmonary oedema results from increased hydrostatic pulmonary capillary pressure (e.g. left ventricular failure), but in ARDS it is a result of increased alveolar capillary PERMIABILITY
Prognosis of ARDS?
50% mortality
Survivors often left with fibrosis
ARDS - clinical features?
Occurs in response to:
DIRECT injury - aspiration, severe pneumonia
INDIRECT injury - sepsis, major trauma, pancreatitis
12 - 24hrs after precipitating events. First signs are of dyspnoea and tachypnoea
How to differentiate causes of pulmonary oedema?
Pulmonary capillary wedge pressure is typically <18mmHg in ARDS.
In cadiogenic pulm oedema, the pulmonary artery pressure increases above 18mmHg
What are the two disease of large airways?
Asthma and COPD