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Pharm E3 > Chemotherapy 2 > Flashcards

Chemotherapy 2 Flashcards

1
Q

Temozolomide MOA

A

Bioactivated into diazomethane which methylates DNA

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2
Q

Temozolomide Thera use

A

Brain (astrocytoma), Melanoma

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3
Q

Temozolomide side effects

A

BMS (thrombocytopenia, neutropenia), HA, Fatigue

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4
Q

Temozolomide MOR

A

Alkyl guanine transferase

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5
Q

Cisplatin MOA

A

Forms DNA adducts which inhibit DNA replication & transcription & lead to breaks & miscoding, N7 guanine

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6
Q

Cisplatin Thera use

A

Testicular, Ovarian, Cervix, Bladder, N/SCLC

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7
Q

Cisplatin side effects

A

BMS, Peripheral neuropathy, Ototoxicity, Hypersentivity rxn (Anaphylaxis) Nephrotoxicity (decrease w/ NS hydration, diuresis, Amifostine: cytoprotective)

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8
Q

Cisplatin MOR

A

Loss of mismatch repair (MMR) ->no apoptosis

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9
Q

Methotrexate MOA

A

Inhibition of Dihydrofolate reductase: decrease DNA, RNA synthesis, S phase specific

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10
Q

Methotrexate therapeutic use

A

ALL, CNS leukemia (IT), GTN, Breast, NHL

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11
Q

Methotrexate side effects

A

Myelosuppression, pneumonitis, mucositis, hepatoxicity, nephrotoxicity, teratogenesis, meningismus (IT)

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12
Q

Methotrexate MOR

A

DHFR gene amplification

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13
Q

Pyrimidine analogs MOA

A

S-phase specific

5-FU → 5-F-deoxyuridine monophosphate, Inhibitor of thymidylate synthase -> decreases DNA synthesis

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14
Q

Pyrimidine analogs therapeutic use

A

5-FU: Colorectal, breast, gastric, pancreatic, esophageal

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15
Q

Pyrimidine analogs side effects

A

5-FU, Capecitabine: N/V/D, Alopecia, Myelosuppression, Hand & Foot syndrome

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16
Q

Purine analogs MOA

A

S-phase specific

6-MP → 6-thioguanine nucleotides, Incorporated in DNA & RNA, Cytotoxicty by decreased RNA & DNA synthesis

17
Q

Purine analogs Therapeutic Uses:

A

6-MP: ALL

18
Q

Purine analogs side effects

A

6-MP : Myelosuppression, N/V/D, Hepatotoxic

19
Q

Vincristine MOA

A

Block cells in mitosis, M-phase specific, bind specifically to tubulin & block its ability to polymerize into microtubules

20
Q

Vincristine Therapeutic Uses

A

HD, NHL, Brain, ALL

21
Q

Vincristine Side Effects

A

Fatal (IT, seizures, coma), Alopecia, Myelosuppression, Neurotoxicity (paresthesia, PN), Constipation (ileus), SIADH

22
Q

Vincristine MOR

A

MDR, MRP, Tubulin mutations

23
Q

Paclitaxel MOA

A

Bind to microtubules & antagonize the disassembly, causes arrest in mitosis, M phase specific

24
Q

Paclitaxel Thera uses

A

Ovarian, N/SCLC, Breast, H/N, KS

25
Q

Paclitaxel side effects

A

Myelosuppression, Peripheral neuropathy, Mucositis (ulcers), Hypersensitivity (50:50 Etoh:Castor oil)

26
Q

Paclitaxel MOR

A

MDR, Tubulin mutations

Pharm E3 (10 decks)

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