Chemotherapeutic Agents Flashcards
1
Q
TOP I
A
S phase (beginning)
2
Q
Antimetabolites
A
Middle of S phase
3
Q
Cytotoxic antibiotics
A
End of S phase or beginning of G2
4
Q
TOP II inhibitors
A
S phase, G2 phase, and M phase
5
Q
Mitotic inhibitors
A
Mitosis
6
Q
Herceptin
A
Antibody is directed to Her2. Blocks cleavage, dimerization, and can cause degradation
7
Q
Gleevec
A
Treats for chronic myelogenous leukemia. Bonds in ATP site of Brc/c-abl enzyme so it can’t cause CML
8
Q
Cetuximab (erbitux)
A
Prevents ligand binding to RTK
