Antibiotics Of Central Dogma

Question 1

Streptomycin

Answer 1

Binds 30s subunit to disrupt initiation of translation

Question 2

Shiga toxin

Answer 2

Binds to 60s subunit to disrupt elongation

Question 3

Clindmycin/Erythromycin

Answer 3

Bind to 50s subunit to disrupt translocation of the ribosome

Question 4

Diphtheria toxin

Answer 4

Inactivates EF2-GTP and inhibits elongation

Question 5

Tetracycline

Answer 5

Binds to small 30s subunit in prokaryotes to block the entry of aminoacyl-tRNA to ribosomal complex

Question 6

Chloramphenicol

Answer 6

Inhibits peptidyl transferase (prok/mito)

Question 7

Cycloheimide

Answer 7

Euk. Elongation inhibitor. Inhibits peptidyl transferase

Question 8

Ricin

Answer 8

Euk elongation inhibitor that binds to large 60s subunit and blocks entry of aminoacyl tRNA to the ribosomal complex.

Question 9

Puromycin

Answer 9

Causes premature chain termination by assembling at the 3’ end of aminoacylated tRNA and adds to the growing chain to form a puromycylated chain that will lead to premature chain release