CHD Flashcards
Risks, atherosclerosis
What does CHD stand for?
Coronary Heart Disease
Give the 9 risk factors for CHD according to the NICE guidelines
High blood pressure, smoking, poor diet, high cholesterol, lack of physical activity, overweight, diabetes, psychological stress, excess alcohol consumption
Why is high blood pressure a risk factor?
Increased pressure of blood flowing through the body can gradually cause damage to the arteries, leading to atherosclerosis. Also could cause aneruysm; constant pressure of blood moving through a weakened artery can cause a bulge that might rupture. Also can put strain on heart, causing failure, or cause left ventricle to thicken and stiffen because of increased hard work, leading to limited ability to pump.
Why is smoking a risk?
Carbon monoxide from the smoke and nicotine make the heart work faster, and increase the risk of blood clots. Other chemicals in the smoke also can lead to damage to lining of arteries, leading to furring.
Why is high cholesterol a risk?
Low density lipoprotein excess can lead to a build up along the vessels, thinning the pathway for the blood, increasing blood pressure. Blood clots can form on the plaques also.
How much total blood cholesterol is the government recommendation?
less than 5mmol/litre
Why is lack of physical activity a risk?
Secondary; physical activity reduces other risks
According to a statement published by the WHO in 1994, what is the difference in risk between inactive and highly active people?
Twofold greater
Why is diabetes a risk? and how much?
type 2 diabetes males 2-4 fold increase risk, 3-5 fold in females. Blood vessels damaged by high glucose levels.
Why is excess alcohol consumption a risk?
Calories son
What ages are at risk for CHD?
men: 45 women: 55 is when it increases
What are three genetic risks for CHD?
familial combined hyperlipidemia (FCHL), Apo-E4 and HPA-2 Met
What is FCHL?
A defect in the way the body metabolizes lipoproteins, leading to higher levels in LDL
What is Apo-E4?
Lipid metabolism
What is HPA-2 Met?
Variation of the platelet glycoprotein gene, makes the blood ‘stickier’