Chapter 9: Blood, Lymphatic System, and Immune System Flashcards
What is Hematology?
Hematology is the healthcare specialty that studies the anatomy and physiology of the blood through tests, procedures, and drugs
What is Hematopoiesis?
Hematopoiesis is the process of the formation of all formed elements in the blood and the body
What is Immunology?
Immunology is the healthcare specialty that studies the anatomy and physiology of the lymphatic system through tests, procedures, and drugs
What does the Lymphatic System consist of?
The Lymphatic System consists of lymphatic vessels, lymph nodes, lymph fluid, the spleen, and the thymas
What does the Lymphatic System form?
Forms a pathway of lymphatic vessels and nodes throughout the body
The Lymphatic System defends the body against what?
Defends the body against invading microorganisms and cancerous cells
What are the two particular types of blood cells The Lymphatic System share?
Shares two particular types of blood cells known as lymphocytes and macrophages (white blood cells)
What are macrophages and lymphocytes?
White blood cells
What happens to immature leukocytes?
immature leukocytes are released into the blood and travel to the thymus
What does the spleen serve as?
the spleen serves as a storage area for reserve supplies of blood
What does the spleen break down and recycle?
The spleen breaks down and recycles old erythrocytes (red blood cells)
What are erythrocytes?
red blood cells
What portion is plasma in the blood?
Plasma is the fluid portion of the blood
What does plasma look like? And how much does it make up?
-clear, straw-colored liquid
-makes up 55% of the total volume of blood
What is the most numerous type of blood cell?
Erythrocytes (red blood cells)
What do Erythrocytes look like?
round, somewhat flattened, red disks
What makes Erythrocytes unique?
they have no cell nucleus when they mature
What do Erythrocytes do?
carry oxygen and carbon dioxide molecules to and from the lungs and each cell in the body
What do Erythrocytes contain?
Erythrocytes contain Hemoglobin
What is hemoglobin
a red iron-containing molecule
What does hemoglobin do? and where does it take place?
-bind to oxygen molecules to form Oxyhemoglobin
-formation takes place in the red marrow of the bones
What are very immature cells known as?
Very immature cells are known as stem cells
What do mature stem cells become?
mature stem cells become erythroblasts and then a normoblast
What is something erythrocytes cannot do?
cannot divide or repair themselves
How long do Erythrocytes have until they deteriorate?
last only 120 days before they begin to deteriorate
What do specialized cells break down their molecules into?
Specialized cells (macrophages) break down their hemoglobin molecules into globins and heme
What are specialized cells?
macrophages
What are Heme molecules converted to?
Heme molecules are converted to bilirubin
What role does Bilirubin play?
Bilirubin plays an important role as an antioxidant
What does Bilirubin protect the body cells against?
Bilirubin protects body cells from damage by free radicals
How many kinds of cells do Leukocytes have?
5 different kinds of cells
-neutrophils
-eosinophils
-basophils
-lymphocytes
-monocytes
How do Leukocytes get identified?
Can be identified based on the presence or absence of granules in their cytoplasm and the shape of the nucleus
What do Leukocytes with large granules in their cytoplasm and segmented nucleus categorized as?
granulocytes
What do Granulocytes include
-neutrophils
-eosinophils
-basophils
-phil
suffix: attraction to
What is the most common type of leukocyte?
Neutrophils
What is the percentage of Neutrophils in the blood?
40-60% in the blood
What are Neutrophils categorized as?
Categorized as granulocytes
What do Neutrophils have a lot of?
Have many lobes
What are Neutrophils known as?
known as polymorphonucleated leukocytes (PMN) or poly
Where do Neutrophils develop?
develop in the red marrow
What does CBC mean?
complete blood count
What would cause a higher count of Neutrophils in the CBC?
Most likely would be a higher count in the CBC if a patient is fighting a bacterial infection
Why are Neutrophils part of the immune response of the lymphatic system?
because they are phagocytes that engulf and destroy bacteria
How long do Neutrophils live if they are actively destroying bacteria?
Live for a few days or hours
What are the 2 least common leukocytes?
-Eosinophils
-Basophils
What are Eosinophils categorized as?
categorized as granulocytes
What are Basophils categorized as?
categorized as granulocytes
Where do Eosinophils develop?
develop in the red marrow
What do Eosinophils do?
Engulf and destroy foreign cells (pollen, and animal dander)
What do Eosinophils release?
Release toxic chemicals that kill parasites that invade the body
What are Eosinophils involved in?
involved in allergen triggers as a localized reaction
How many lobes does the nucleus of a basophil have?
2 lobes
Where do basophils develop?
develop in red marrow
What does basophil release?
-Release histamine at the site of tissue damage
-release heparin
What is heparin?
an anticoagulant
What is the second most common leukocyte?
Lymphocytes
What are lymphocytes categorized as? Why?
-categorized as agranulocytes
-because the granules in their cytoplasm are nearly invisible
How long do Lymphocytes live?
Some live for a few days or many years
Where do lymphocytes begin their development?
begin their development in the red marrow
Where are lymphocytes present?
-blood
-lymph nodes
-lymphoid tissue
-organs of the lymphatic system
What is the largest but one of the least common leukocytes in the blood?
Monocytes
Why are Monocytes categorized as? Why?
categorized as agranulocytes because the granules in their cytoplasm are nearly invisible
What do Monocytes have a large amount of?
have a large amount of cytoplasm
What are the monocytes nucleus shaped as?
kidney beans
Where do Monocytes develop?
develop in the red marrow
What are monocytes?
phagocytes
What do monocytes do?
engulf and destroy all types of invading microorganisms, cancerous cells, dead leukocytes, and cellular debris
Where are monocytes found?
Found in the blood and in the lymph nodes of the lymphatic system
Why are Thrombocytes different from other blood cells?
Because they are only cell fragments
What is another name for thrombocytes?
Platelets
What is another name for thrombocytes?
Platelets
Where do thrombocytes go when they begin? and what do they become after?
-begin in the red marrow as stem cells
-then become megakaryoblasts
What does the cytoplasm of megakaryocytes’ do?
constantly breaks away at the edge to form the cell fragments that are released into the blood
What are other substances in the plasma?
-Electrolytes
-Albumin
(There are more these are the highlighted ones on the notes)
What are examples electrolytes?
Sodium, Potassium, Calcium, Magnesium, And Bicarbonate
What is the most abundant protein dissolved in the blood?
Albumin
What does Albumin do?
Prevents too much water from escaping into tissue during inflammatory reactions
What are the blood types called?
- A
- B
- AB
- O
AB blood is a:
Universal recipient
What type O is blood known as? Why
- known as the universal donor
- because it can be given to patients with any other blood type without causing a reaction
How many antigens does the Rh blood group have?
47 antigens
When is Rh positive?
positive when antigens are present on erythrocytes
When is RH negative?
Negative when antigens are not present on erythrocytes
Where is RH carried?
Carried in the red blood cells
How is our blood type determined?
Through RHs’ genetic material that is carried in the red blood cells