Chapter 9 Flashcards
Staphylococcus aureus
MRSA ( methicillin resistant )
- it is a modified membrane protein that does not bind methicillin
MRSA
can have fitness costs to bacterial cell in absence of antibiotics because they are hard to eliminate
messes up cellular machinery, not as good as wild type.
without methicilin (antibiotic)
several genes affecting a system
polygenic traits
so much variation that not all genotypes are expressed
latent variation
could shift allele frequency
selection
can pull out new phenotypes without mutation
reassortment
Genes at 2 or more loci interact in nonadditive ways
Epistasis
Effects of one depend on context set by other
Phenotypic effect of loci context dependent
ex/ beach mice
-then natural selection acts on the combination of genes that produce certain phenotypes
if a favorable allele is liked to another
genetic hitchhiking
Even an unfavorable allele may increase in frequency
Genetic Linkage
Further apart genes will break this association faster
Genetic Linkage
Diversity in loci around selected locus less than neutral model
Genetic Linkage
Can work in reverse
Genetic Linkage
deleterious alleles may take good one with them
background selection
-result of genetic linkage
reduce variation
genetic linkage
Favorable gene arises in population & goes to fixation, takes everything with it
-selective sweep
-this happens in periodic selection
( process repeats )
genes in a selective sweep can be added by
tansposons and plasmids
resistant bacteria had more resistance to other antibiotics than sensitive strains
sufonamide
if two beneficial mutations are in a population
no recombination
-one will be driven out via competition
the slowing down of selection is known as
clonal interference
Pleiotropy – single gene with multiple effects on phenotype
Epistasis – a phenotypic trait is determined by complex interactions among multiple genes
Norms of reaction – a single genotype produces different phenotypes in different environments
Dominance – one allele masks the effect of another
Multiple pathways – a common phenotype may have different genetic bases.
adaptive landscapes
idea behind adaptive landscape
phenotypic space ( mophospace)
morphological values for characters
phenotypic space
Inflorescence length and leaf length
Can be more than 2 dimensions
Phenotypic space