chapter 8: transport in humans Flashcards
what are the percentages of the components in blood?
- about 55% of the volume of blood is made up of plasma
- 45% is made up of blood cells and platelets
what is plasma and what does it contain?
- it is a pale yellowish liquid
> about 90% water and a complex mixture of dissolves substances such as:
-
soluble proteins like fibrinogen and prothrombin and antibodies
> fibrinogen and prothrombin play an important part of clotting blood
>antibodies help fight diseases
> these proteins are made in the liver - dissolved mineral salts:
> hydrogen carbonates, chlorides, sulfates and phosphates of calcium, sodium and potassium
> all these are ions in plasma
> calcium is essential for blood clotting - food substances like: glucose, amino acids, fats and vitamins
- excretory products: urea, uric acid and creatinine
- hormones like insulin
how many red blood cells or erythrocytes do we have and what are they?
- about 5 mill of erythrocytes in each cubic milimeter of blood
> number varies according to gender and state of health of a person - each mammalian blood has these features:
1. contains the pigment haemoglobin
> a special kind of iron-containing protein - haemoglobin combines reversibly with oxygen
> enables red blood cells to transport oxygen from the lungs to all cells in the body
- circular, flattened biconcave disc
> centre of the cell is thinner than the edge
> this increases the cell’s surface area to volume ratio
> cell can thus absorb and release oxygen at a faster rate - it does not possess a nucleus, enabling it to carry more haemoglobin and thus more oxygen
- it is elastic and can turn bell shaped- in order to squeeze through blood vessels smaller than itself in diameter
where are red blood cells produced and how long do they last?
- red blood cells are produced by the bone marrow
- have a lifespan of about 3 to 4 months
- when they are worn out, they are destroyed in the spleen
- haemoglobin that is released from destroyed red blood cells is brought to the liver and broken down
what are white blood cells (leucocytes) and what is its ratio to red blood cells?
- leucocytes are larger than red blood cells but are fewer in number
- ratio of RBC: WBC > 700:1
- in each cubic millimeter of of blood, only 50,000-10,000 WBC but about 5 million RBC
white blood cells have: - colourless and does not contain haemoglobin
- irregular in shape and contains a nucleus
- it can move, change shape and squeeze through walls of the thinnest blood capillaries into the spaces among the tissue cells
two main kind of white blood cells:
> lymphocytes and phagocytes
- white blood cells plays a vital role in keeping the body healthy by fighting diseases
- although they contain a nucleus
> lifespan in the bloodstream is only a few days
what are lymphocytes?
- each lymphocyte has a large, rounded nucleus and a relatively small amount of non-granular cytoplasm
- tend to be round in shape and only show limited movements
- they produce antibodies that may protect the body from disease-causing microorganisms
what are phagocytes?
- they can ingest
> which is to take in and digest foreign particles such as bacteria - it has a lobed nucleus and granular cytoplasm
what are blood platelets(thrombocytes?)
- they are not true cells
> they are membrane-bound fragments of cytoplasm from certain bone marrow cells - they play a part in clotting of blood
what causes clumping of red blood cells?
- the surfaces of your red blood cells contain special proteins
> antigens - the same antigens are found on all your red blood cells
- your blood plasma contains antibodies which are always present in the blood
- these natural antibodies will not react with the antigens on your blood cells but may with the red blood cells of another person
> this causes agglutination
eg: agglutination will occur when
> antigen A mixes with antibody a
> antigen B mixes with antibody b
what is a blood group?
- you can be classified into a blood group based on the types of antigens and antibodies present in your blood
- antigens are represented by A and B
- antibodies against antigens A and B may be represented by a and b
- antibody a reacts with antigen A and clumping occurs
> blood test will tell you which blood group you belong to
> A, B, AB or O
just read:
if you belong to blood group A, your red blood cells possess antigen A and your serum contains antibody b
- your serum could not contain antibody a or your own red blood cells would agglutinate
“When you have a dream, you’ve got to grab it and never let go.”
what are the 3 functions of blood?
- acts as a transport medium carrying various substances from one part of the body to another
- it protects the body against disease-carrying organisms (pathogens)
- blood clotting at wounds prevents excessive loss of blood
> clotting seals the wound and prevents the entry of bacteria into the bloodstream
what digested food does blood transfer?
( + carried from where and to where)
- glucose, amino acids, mineral salts, fats and vitamins are carried
> from intestines - to other parts of the body
- excess mineral salts are transported to the kidneys for excretion
what excretory products does blood transfer?
( + carried from where and to where)
- nitrogenous wastes
> urea, uric acid, creatine
> from all parts of the body
- to the kidneys - carbon dioxide
> carried as hydrogencarbonate ions in plasma
> from all parts of the body to
- lungs, where hydrogencarbonate ions are converted to carbon dioxide and expelled
where do blood carry hormones from and to where?
- carries hormones from glands to target organs
where does blood carry heat from and to?
- carries heat from respiring body tissues
> eg muscles - to all parts of the body to maintain a uniform body temperature
where does blood carry oxygen from and where to?
- blood carries oxygen from lungs to all parts of the body for cellular respiration
how does blood transport oxygen to the cells of the body?
- as blood passes through the lungs,
> oxygen diffuses from the alveoli into the blood - haemoglobin has a great affinity for oxygen, haemoglobin can combine reversibly with oxygen
> in lungs, where oxygen level is high, haemoglobin in the red blood cells combine with the oxygen to form oxyhaemoglobin - red blood cells then transports oxyhaemoglobin to all the tissues of the body
- as blood passes through tissues ( containing very little oxygen), oxyhaemoglobin releases its oxygen
> the oxygen then diffuses in solution into the tissue cells
what is coagulation of blood?
( what happens when someone’s blood doesn’t clot?)
- blood exposed to air will form a solid lump
- the clot seals the wound to prevent the loss of excessive blood
> clot also prevents foreign particles from entering the bloodstream - when people suffer from a heredity disease called haemophilia
> the normal blood-clotting mechanism is greatly impaired
> slight injuries may cause such a person to bleed to death or die of internal bleeding
describe the process of blood clotting.
- when blood vessels are damaged, damaged tissues and blood platelets release an enzyme known as thrombokinase
- thrombokinase converts the protein prothrombin, usually present in plasma into thrombin
> ( calcium ions need to be present before this can take place)
-thrombin is also an enzyme which catalyses the conversion of the soluble protein fibrinogen into insoluble threads of fibrin
> fibrin threads entangle blood cells and the whole mass forms a clot or a scab
clot seals the wound to prevent the entry of microorganisms
does blood clot in undamaged blood vessels?
- normally, it does not clot
> dues to presence of anti-clotting substance (heparin)
> heparin is produced in the liver - when thrombokinase is released, it neutralises the action of heparin > so clotting takes place
- when blood clots, a yellowish liquid called serum in left behind
> serum has the same composition as plasma except that it lacks the clotting factors
what are the three reactions of the clotting process?
- damaged tissues and platelets > (produce) > thrombokinase
- prothrombin inactive > (thrombokinase and calcium ions) > thrombin active
- fibrinogen > (thrombin) . insoluble fibrin threads form mesh to trap blood cells