Chapter 8 - Quiz 3 Flashcards
8.1 Endogenous Rhythms
Define endogenous circannual rhythm. Give an example. (2)
-An internal rhythm that follows the year/seasons
-Example: birds know when to fly back North, even if they’re kept in a cage
8.1 Endogenous Rhythms
Define endogenous circadian rhythms. Give an example.
-internal rhythm that corresponds to a 24 hour cycle
-Example: humans get internal cues on when to sleep, eat, when we have more energy etc
-circadian rhythms affect much more than just waking and sleeping, we have circadian rhythms for eating, drinking, urination, hormone secretion, metabolism and sensitvity to drugs
8.1 Setting and Resetting the biological clock
Define zeitgeber. List them. (2)
-stimulus that resets the circadian rhythm
-light is the most dominant, activity, arousal of any kind, meals, and temperature of the environment
-note that social stimuli is not a zeitgeber
8.1 Setting and Resetting the biological clock: Jet Lag
What is phase-delay and phase-advance? (2)
-phase delay is when you go to bed later and wake up later
-phase-advance is the opposite
8.1 Mechanisms of the biological clock: the suprachiasmatic nucleus
Define the suprachiasmatic nucleus (SCN). Where is it in the body?
-the main driver of rhythms for sleep and body temperature, it is located above the optic chiasm (it gets its name from this)
-after damage to the SCN, the body’s rhythms becoe erratic
8.1 Mechanisms of the biological clock: the suprachiasmatic nucleus
What evidence strongly indicates that the SCN produces the circadian rhythm itself? (2)
-SCN cells produce a circadian rhythm of activity even if they are kept in cell culture isolated from the rest of the body.
-Also, when hamsters received transplanted SCN neurons, their circadian rhythm followed the pattern of the donor animals.
-the SCN generates circadian rhythms itself in a genetically controlled manner.
-the rhythm follows the pace of the donor not the recipient
8.1 Mechanisms of the biological clock: how light resets the SCN
How does light reset the biological clock? Where do the axons comprising that path originate from and what do they respond to? (2)
-A branch of the optic nerve, the retinohypothalamic path,
-The axons comprising that path originate from special ganglion cells that respond to light by themselves and have their own photopigment, even if they do not receive input from rods or cones.
8.1 Mechanisms of the biological clock: how light resets the SCN
People who are blind because of cortical damage can still synchronize their circadian rhythm to the local pattern of day and night. Why?
-If the retina is intact, melanopsin-containing ganglion cells can still send messages to the SCN, resetting its rhythm.
8.1 Mechanisms of the biological clock: the biochemistry of the circadia
How do the proteins TIM and PER relate to sleepiness in Drosophila? Explain their concentration throughout the day, evening and night. How do they stop producing? (4)
-The proteins TIM and PER remain low during most of the day and begin to increase toward evening.
-They reach high levels at night, promoting sleep.
-They also feed back to inhibit the genes that produce them, so that their level declines toward morning.
-light activates a chemical that breaks down the TIM protein, increasing wakefulness and synchronizing the internal clock with the external world
-mammals have three versions of the PER protein and several proteins closely related to TIM and the others found in flies
8.1 Mechanisms of the biological clock: melatonin
What other areas of the brain does the SCN regulate waking and sleeping by controlling activity levels in? Define the structure
-pineal gland: endocrine gland located posterior to thalamus, releases melatonin
-melatonin is found in almost all animals, in diurnal animals it increases sleepiness and in nocturnal animals it increases wakefulness
8.1 End of module quiz
Workers on certain submarines work 6 hours, relax 6 hours, and then sleep 6 hours. After weeks on this schedule, what happens to their circadian rhythm?
-It continues producing the usual 24-hour rhythm.
8.1 End of module quiz
For most young adults, what happens to mood as a function of time of day?
-Mood tends to be most pleasant in late afternoon or early evening.
8.1 End of module quiz
What evidence most strongly indicates that the SCN produces the circadian rhythm itself?
a) Damage to the SCN disrupts the circadian rhythm.
b) SCN cells isolated from the body continue to produce a circadian rhythm.
b) SCN cells isolated from the body continue to produce a circadian rhythm.
8.1 End of module quiz
Light can reset the SCN’s rhythm even after damage to all rods and cones. Why?
-The SCN receives input from ganglion cells that respond to light.
8.2 Sleep and other interruptions of consciousness
Contrast a sleep with a coma, vegetative state, minimally conscious state and brain dead. (5)
Sleep: is a state that the brain actively produces, by decreased activity and decreased response to stimuli
Coma: is extended period of unconsciousness caused by head trauma, stroke or disease and have low brain activity and no response to stimuli
Vegetative state: alternates between periods of sleep and moderate arousal, the person shows no awareness of surroundings or purposeful behavior, but may show an ANS response to painful stimulus
Minimally conscious state: is one stage higher with brief periods of purposefull actions and limited amount of speech comprehension
Brain death: has no brain activity and no response to any stimulus
8.2 Stages of sleep
What is a polysomnograph? What does it record?
-it records both EEG and eye movement
-EEG is like recording the sound in a stadium, you dont get individual stuff but you will be able to hear trends
8.2 The stages of sleep
What are alpha waves? What are they characteristic of? (2)
-type of brain wave that occur at a frequency of 8-12 per second
-characteristics of relaxation, not of all wakefulness
8.2 The Stages of Sleep
How many stages of sleep are there? Describe the order they go in. (2)
-4: non-rapid eye movement (NREM) stage 1, NREM stage 2, NREM stage 3 and REM
-N1 to N2 to N3, then after about an hour you go back to N2 then REM and this sequence repeats with each cycle lasting about 90 minutes
8.2 The Stages of Sleep
Describe the first stage of sleep? NREM stage 1, When does it happen? What does the EEG show? How does it compare to other stages? (3)
-when sleep has just begun
-the EEG has irregular, jagged, low voltage waves
-brain activity is less than wakefulness, but higher than in other sleep stages
8.2 Stages of Sleep
Describe stage 2. What are the prominent characteristics of it?
-deeper sleep than N1 and has sleep spindles and K-complexes
8.2 Stages of sleep
What are sleep-spindles? What are they the result from? Why do they increase in number? (3)
-burst of 12-14 Hz waves for a least half a second
-result from oscillating interactions between cells in thalamus and cortex
-they increase after new learning and the number of sleep spindles is positively correlated with improvements in certain types of memory
8.2 Stages of sleep
What is the K-complex?
-sharp wave associated with temporary inhibition of neuronal firing