Chapter 8 Flashcards
Which immunoglobulin is expressed only by naive B cells
IgM
Where are MHC I found and what do they bind to?
Found in all cells of the body that have nucleus (non RBCs)
Attach to CD-8 receptor of Cytotoxic T Cells
Name the class of immunoglobulin
•Secreted during primary response.
IgM
Helper T cells communicate with MHC class?
MHC class 2
Name the class of Immunoglobulins:
Principal antibody in allergic response
Associated with mast cells and basophils
IgE
mature B cells express which immnoglobulins
IgM
IgD
3rd Line of Defense
Humoral response
•B lymphocytes:
B cells, plasma cells, immunoglobulins; memory cel
What is clonal selection
- Differentiation into antibody-secreting plasma cells.
- Antigen binds with receptors triggers production of plasma and memory cells.
for review
for review
•transported to lysosomes which contain exogenous antigens.
Meets up with pathogen in cytoplasm
MHC class 2
What is this?
- IgA dominant secretory immunoglobulin.
- Prevents attachment and invasion of pathogens through mucosal membranes.
Secretory immue system
Name the class of Immunoglobulins:
Main antibody in external secretions.
IgA
•Bind outside the normal antigen specific binding site to the TCR b-chain or to the MHC class II molecule a-chain outside antigen-presentation site.
Superantigens SAGs
T helper cells 17 increases what?
Inflammatory responce
Name the class of immunoglobulin
Functions as antigen receptors
IgD
What is this describing?
- Instruct target cell to respond.
- Increase production of plasma membrane receptors.
- Initiate proliferation and differentiation for T and B Cells.
Cytokines
What is colonal diversity
Talking about B Cell responce
This is when they are in the bone marrow and immature
They replicate with lots of diffrent receptors (antibodies)
Do the following things describe virus or bacteria?
- Larger in size.
- Living organisms that can reproduce.
- single-celled “living” microorganisms that reproduce by dividing.
- Contain DNA and ribosomes for replication.
- Rigid cell wall.
- Thin, rubbery cell membrane.
- May have flagella.
- Make toxins that can damage the cells they’ve invaded.
bacteria
Which portion of the antibody is this
•CDRs fold.
•Contain receptors for antigenic determinants.
Confer specificity
Antigen binding fragment - Fab
What are CD1 and where are they found?
- Found on APCs and cells in thymus.
- Presents lipid antigens:
- Lipoproteins, glycolipids, and other molecules
What do superantigens do
excessive prduction of cytokines
•IL-2, IFN-g, TNF-a.
In active immunity the Primary Response usually includes what?
This is the initial exposure to the antigen
The B Cells Secrete mostly IgM antibodies
What are the three things the antibodies can do
- neutralization
- opsonization
- activate complement
Does the following describe a bacteria or virus?
- May have outer envelope.
- All have a protein coat
- Core of genetic material (DRA or RNA).
- Not “living” organisms.
- They require living hosts to multiply. Otherwise, they can’t survive.
- Takes over the cell’s DNA, redirecting it to reproduce.
- May eventually kill the host cells.
virus
What typically takes place with active immunity secondary response ?
- Subsequent exposure to same antigen.
- Maximum antibody concentration reached in < 2 hrs.
- IgG dominates
Which part of the antibody is this
•Bind to surface of effector cells of inflammation.
Crystalline fragment (Fc)
Where are MHC class II recepotrs found and what do they attach to
Found in B-Cells - Macrophages - Epithelial cells
They attach to CD-4 receptors on the T Helper Cell
The following stages describe what
•Stem cells.
•Pro-B cells.
•Pre-B cells.
•Immature B cells.
•Mature B cells.
•Secrete antibodies into the blood and lymph.
•Stimulate production of memory cells.
Humoral Immunity
