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Blood Bank Crystal > Chapter 7 The Rh Blood Group System > Flashcards

Chapter 7 The Rh Blood Group System Flashcards

1
Q

Upper case R (R)

A

presence of D antigen

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2
Q

Lower case r (r)

A

absence of D antigen

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3
Q

Wiener System

indicated by 1 or ‘

A

upper case C (C)

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4
Q

When there is no ‘ or 1

A

lower case c(c)

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5
Q

R^1 =?

A

DCe

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6
Q

r’ =?

A

Ce

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7
Q

R^0 =?

A

Dce

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8
Q

indicated by 2 or “

A

upper case E (E)

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9
Q

When there is no 2 or “

A

lower case e (e) is implied

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10
Q

R^2 =

A

DcE

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11
Q

r” =

A

cE

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12
Q

r =

A

ce

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13
Q

letter z or y is used when both C and E are upper case

A 
R^z = DCE
r^y = CE
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14
Q

The Rh system was first recognized in a case report of:

A

A hemolytic transfusion reaction

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15
Q

What antigen is found in 85% of the white population and is always significant for transfusion purposes?

A

D

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16
Q

How are weaker-than-expected reactions with anti-D typing reagents categorized?

A

Weak D

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17
Q

Cells carrying a weak-D antigen require the use of what test to demonstrate its presence?

A

(IAT) indirect antiglobulin tets

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18
Q

How are Rh antigens inherited?

A

co-dominant alleles

19
Q

Biochemically speaking, what type of molecules are Rh antigens?

A

Proteins

20
Q

Rh antibodies react best at what temperature (C)?

A

37 degrees C

21
Q

Rh antibodies are primarily of which immunoglobulin class?

A

IgG

22
Q

Rh antibodies have been associated with which of the following clinical conditions?

A

Stomatocytosis

23
Q

What do Rh-null cells lack?

A

Rh antigens

24
Q

What antigen system is closely associated phenotypically with Rh?

A

LW or Landsteiner Weiner

25
Q

Anti-LW will not react with what?

A

Rh null RBC

26
Q

What most commonly causes an individual to type RhD positive yet possess anti-D?

A

Partial D

27
Q

Convert the following genotypes from Wiener nomenclature to Fisher-Race:

  1. R1r
  2. R2RO
  3. RzR1
  4. ryr
A
  1. DCe/dce
  2. DcE/Dce
  3. DCE/DCe
  4. dCE/dce
28
Q

Which RH phenotype has the strongest expression of D?

A

D-

29
Q

An individual has the following Rh phenotype: D+C+E+c+e+. Using Fisher-Race terminology, what is their most likely Rh genotype?

A

DCe/DcE

30
Q

What is the most common Rh phenotype in African Americans?

A

Dce/dce

31
Q

In the Fisher-Race nomenclature what does “d” refer to?

A
  • amorph
  • silent allele
  • absence of D
32
Q

What is the frequency of E antigen in the general population?

A

30%

33
Q

What does hr’ refer to in the Weiner nomenclature?

A

c

34
Q

All of the following are consistent with International Society of Blood Transfusion (ISBT) terminology except:

    a) A six digit number specifies each blood group antigen
 	b) 004 represents Rh group
 	c) D is written as "RH 1"
    d) All genes are written in bold print
A

d) All genes are written in bold print

35
Q

Where is the Rh antigen located relative to the red cell membrane?

A

integrally

36
Q

Why is it acceptable for “C Trans” individuals to receive D-positive red cells?

    a) the structure of the D antigen is complete
 	b) the Du is a result of steric complications
 	c) the Rh antigen on the red cell is normal                             		      
    d) all of the above
A

d) all of the above

37
Q

Why is determination of Rh status crucial for obstetric patients?

A

All Rh negative mothers are possible candidates for Rh immune globulin

38
Q

Which IgG subclasses carry the most significance with regard to Rh antibodies?

A

IgG1/IgG3

39
Q

All of the following may cause a false negative reaction in Rh typing except:

    a) omission of reagent
 	b) immunoglobulin coating cells
    c) rouleaux
 	d) cell suspension too heavy
A

c) rouleaux

40
Q

All of the following may occur following an Rh-mediated hemolytic transfusion reaction except:a) elevated fever

b) increased bilirubin

c) intravascular hemolysis
 	d) positive DAT
A

c) intravascular hemolysis

41
Q

What genotype is consistent with f antigen expression?

A

Dce/DCE

42
Q

G antigen is present on all of which type of red cells?

A

C positive

43
Q

If a person has a genotype of LWa LWb, what is his or her phenotype?

A

LW (a+b+)

Blood Bank Crystal (8 decks)

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