Chapter 42- Herpesviridae CMV and EBV

Question 1

describe the characteristics of the Epstein Barr virus

Answer 1

double stranded DNA virus

Question 2

What does the mono spot test check for?

Answer 2

The heterophiles Ab

Question 3

Pathogenesis of EBV

Answer 3

disease is the result of viral replication and host response to viral Ag. EBV infects epithelial cells of the mouth and throat.

Question 4

Cancers associated with EBV

Answer 4

1. Hodgkin lymphoma
2. Burkitt lymphoma
3. Nasopharyngeal carcinoma
4. Oral hairy leukoplakia

Question 5

Describe an EBV infection

Answer 5

enlarged cervical nodes and splenomegaly. low grade fever with no extreme elevations in WBC

Question 6

Describe an CMV infection

Answer 6

Cervical nodes;splenomegaly not as common. systemic symptoms and fever predominate.

Question 7

Cytomegalovirus

Answer 7

Productive infection in epithelial cells acquired from blood, tissue, and most body secretions. Latency in monocytes, dendritic cells, megakaryocytic and myeloid progenitor cells.

Question 8

Clinical presentation and DX of CMV

Answer 8

Heterophile Ab negative. CMV-specific IgM or 4 fold increase in CMV-specific IgG. IgM can be positive for months. Use amplification Assays.

Question 9

Outcomes for CMV

Answer 9

1. Normal immunity- asymptomatic carrier. mono like illness
2. Baby (mom seronegative)- cytomegalovirus inclusion disease with CNS disease.
3. AIDS and immunosuppressed- multisite symptomatic disease

Question 10

Roseola

Answer 10

Caused by HHV 6 and 7. fever first, then rash later. generally uncomplicated and mild.