Chapter 40- Papilloma and Parvovirus

Question 1

Describe parvovirus B19

Answer 1

small, naked, single stranded DNA

Question 2

Fifth Disease

Answer 2

Caused by parvovirus B19. grows in red blood cells and can lead to aplastic crisis. Causes slapped rash, which is a rash that develops when no longer contagious. the diagnosis for fifth disease is done from the rash.

Question 3

Polyomaviridae characteristics

Answer 3

double stranded DNA, naked capsule with icosahedral symmetry. Uncommon oncogenic potential. Genome integrated in transformed cells.

Question 4

Papillomaviridae characteristics

Answer 4

double stranded DNA, naked capsule with icosahedral symmetry. common oncogenic potential. Genome circular in warts, integrated in carcinoma.

Question 5

describe the human papillomavirus characteristics

Answer 5

nonenveloped double stranded circular DNA

Question 6

Progression of HPV infection

Answer 6

virus is highly tropic for epithelial cells of skin and mucus membrane. development of epithelium is essential for development of virus particles.

Question 7

Genital infections

Answer 7

most HPV serotypes are not associated with condyloma acuminatum (CA) but several are (ex 16 & 18). most genital hpv infections are transient, asymptomatic and have no clinical consequences in immunocompetent individuals.

Question 8

Median duration of new cervical infections

Answer 8

8 months

Question 9

Persistent HPV infection

Answer 9

• not cleared by immune system
• characterized by persistently detectable type-specific HPV DNA.
• persistent oncogenic HPV infections is most important risk factor for pre cancerous cervical cellular changes and cervical cancer.

Question 10

what can happen to babies born to mothers that have genital warts

Answer 10

they can occasionally develop warts in the respiratory tract.

Question 11

GARDASIL vaccine

Answer 11

polyvalent vaccine. Capsid protein antigen made in yeast; the capsid proteins then self assemble to “look” like the virus but can’t replicate. Four types: 6, 11, 16, 18

Question 12

Cervarix vaccine

Answer 12

for females only, covers types 16 and 18