CHAPTER 41: QUALITATIVE DISORDERS OF PLATELETS AND VASCULATURE Flashcards
(1) The clinical presentation of platelet-related bleeding may include all of the following except:
a. Bruising
b. Nosebleeds
c. Gastrointestinal bleeding
d. Bleeding into the joints (hemarthroses)
d. Bleeding into the joints (hemarthroses)
(2) A defect in GP IIb/IIIa causes:
a. Glanzmann thrombasthenia
b. Bernard-Soulier syndrome
c. Gray platelet syndrome
d. Storage pool disease
a. Glanzmann thrombasthenia
(3) Aspirin ingestion blocks the synthesis of:
a. Thromboxane A2
b. Ionized calcium
c. Collagen
d. ADP
a. Thromboxane A2
(4) Patients with Bernard-Soulier syndrome have which of the following laboratory test findings?
a. Abnormal platelet response to arachidonic acid
b. Abnormal platelet response to ristocetin
c. Abnormal platelet response to collagen
d. Thrombocytosis
b. Abnormal platelet response to ristocetin
(5) Which of the following is the most common of the hereditary platelet function defects?
a. Glanzmann thrombasthenia
b. Bernard-Soulier syndrome
c. Storage pool defects
d. Multiple myeloma
c. Storage pool defects
(6) A mechanism of antiplatelet drugs targeting GP IIb/IIIa function is:
a. Interference with platelet adhesion to the subendothelium by blocking of the collagen binding site
b. Inhibition of transcription of the GP IIb/IIIa gene
c. Direct binding to GP IIb/IIIa
d. Interference with platelet secretion
c. Direct binding to GP IIb/IIIa
(7) The impaired platelet function in myeloproliferative neoplasms results from:
a. Abnormally shaped platelets
b. Extended platelet life span
c. Increased procoagulant activity
d. Decreased numbers of a- and dense granules
d. Decreased numbers of a- and dense granules
(8) Which is a congenital qualitative platelet disorder?
a. Senile purpura
b. Ehlers-Danlos syndrome
c. Henoch-Schönlein purpura
d. Waldenström macroglobulinemia
b. Ehlers-Danlos syndrome
(9) In uremia, platelet function is impaired by higher than normal levels of:
a. Urea
b. Uric acid
c. Creatinine
d. NO
d. NO
(10) The platelet defect associated with increased paraproteins is:
a. Impaired membrane activation owing to protein coating
b. Hypercoagulability owing to antibody binding and membrane activation
c. Impaired aggregation because the hyperviscous plasma prevents platelet-endothelium interaction
d. Hypercoagulability because the increased proteins bring platelets closer together, which leads to inappropriate aggregation
a. Impaired membrane activation owing to protein coating