CHAPTER 29: NONMALIGNANT LEUCOCYTE DISORDERS

Question 1

(1) Which of the following inherited leukocyte disorders is caused by a mutation in the lamin B receptor?

a. Pelger-Huët anomaly
b. Chédiak-Higashi disease
c. Alder-Reilly anomaly
d. May-Hegglin anomaly

Answer 1

a. Pelger-Huët anomaly

Question 2

(2) Which of the following inherited leukocyte disorders is one of a group of disorders with mutations in nonmuscle myosin heavy-chain IIA?

a. Pelger-Huët anomaly
b. Chédiak-Higashi disease
c. Alder-Reilly anomaly
d. May-Hegglin anomaly

Answer 2

d. May-Hegglin anomaly

Question 3

(3) Which of the following inherited leukocyte disorders might be seen in Hurler syndrome?

a. Pelger-Huët anomaly
b. Chédiak-Higashi disease
c. Alder-Reilly anomaly
d. May-Hegglin anomaly

Answer 3

c. Alder-Reilly anomaly

Question 4

(4) Which of the following lysosomal storage diseases is characterized by macrophages with striated cytoplasm and storage of glucocerebroside?

a. Sanfilippo syndrome
b. Gaucher disease
c. Fabry disease
d. Niemann-Pick disease

Answer 4

b. Gaucher disease

Question 5

(5) The neutrophils in chronic granulomatous disease are incapable of producing:

a. Hydrogen peroxide
b. Hypochlorite
c. Superoxide
d. All of the above

Answer 5

d. All of the above

Question 6

(6) Individuals with X-linked SCID have a mutation that affects their ability to synthesize:

a. Deaminase
b. Oxidase
c. IL-2 receptor
d. IL-8 receptor

Answer 6

c. IL-2 receptor

Question 7

(7) An absolute lymphocytosis with reactive lymphocytes suggests which of the following conditions?

a. DiGeorge syndrome
b. Bacterial infection
c. Parasitic infection
d. Viral infection

Answer 7

d. Viral infection

Question 8

(8) What leukocyte cytoplasmic inclusion is composed of ribosomal RNA?

a. Primary granules
b. Toxic granules
c. Döhle bodies
d. Howell-Jolly bodies

Answer 8

c. Döhle bodies

Question 9

(9) The expected complete blood count (CBC) results for women in active labor would include:

a. High total white blood cell (WBC) count with increased lymphocytes
b. High total WBC count with a slight shift to the left in neutrophils
c. Normal WBC count with increased eosinophils
d. Low WBC count with increased monocytes

Answer 9

b. High total WBC count with a slight shift to the left in neutrophils

Question 10

(10) Which of the following is true of an absolute increase in lymphocytes with reactive morphology?

a. The population of lymphocytes appears morphologically homogeneous.
b. They are usually effector B cells.
c. The reactive lymphocytes have increased cytoplasm with variable basophilia.
d. They are most commonly seen in bacterial infections.

Answer 10

c. The reactive lymphocytes have increased cytoplasm with variable basophilia.