12: LEUKOCYTE DEVELOPMENT, KINETICS, AND FUNCTIONS

Question 1

(1) Neutrophils and monocytes are direct descendants of a common progenitor known as:

a. CLP
b. GMP
c. MEP
d. HSC

Answer 1

b. GMP

Question 2

(2) The stage in neutrophilic development in which the nucleus is indented in a kidney bean shape and the cytoplasm has secondary granules that are lavender in color is the:

a. Band
b. Myelocyte
c. Promyelocyte
d. Metamyelocyte

Answer 2

d. Metamyelocyte

Question 3

(3) Type II myeloblasts are characterized by:

a. Presence of fewer than 20 primary granules per cell
b. Basophilic cytoplasm with many secondary granules
c. Absence of granules
d. Presence of a folded nucleus

Answer 3

a. Presence of fewer than 20 primary granules per cell

Question 4

(4) Which one of the following is a function of neutrophils?

a. Presentation of antigen to T and B lymphocytes
b. Protection against reexposure by same antigen
c. Nonspecific destruction of foreign organisms
d. Initiation of delayed hypersensitivity response

Answer 4

c. Nonspecific destruction of foreign organisms

Question 5

(5) Which of the following cells are important in immune regulation, allergic inflammation, and destruction of tissue invading helminths?

a. Neutrophils and monocytes
b. Eosinophils and basophils
c. T and B lymphocytes
d. Macrophages and dendritic cells

Answer 5

b. Eosinophils and basophils

Question 6

(6) Basophils and mast cells have high-affinity surface receptors for which immunoglobulin?

a. A
b. D
c. E
d. G

Answer 6

c. E

Question 7

(7) Which of the following cell types is capable of differentiating into osteoclasts, macrophages, or dendritic cells?

a. Neutrophils
b. Lymphocytes
c. Monocytes
d. Eosinophils

Answer 7

c. Monocytes

Question 8

(8) Macrophages aid in adaptive immunity by:

a. Degrading antigen and presenting it to lymphocytes
b. Ingesting and digesting organisms that neutrophils cannot
c. Synthesizing complement components
d. Storing iron from senescent red cells

Answer 8

a. Degrading antigen and presenting it to lymphocytes

Question 9

(9) Which of the following is the final stage of B cell maturation after activation by antigen?

a. Large, granular lymphocyte
b. Plasma cell
c. Reactive lymphocyte
d. Immunoblast

Answer 9

b. Plasma cell

Question 10

(10) The following is unique to both B and T lymphocytes and occurs during their early development:

a. Expression of surface antigens CD4 and CD8
b. Maturation in the thymus
c. Synthesis of immunoglobulins
d. Rearrangement of antigen receptor genes

Answer 10

d. Rearrangement of antigen receptor genes