Chapter 4 Eye, Ear, Nose, Throat Flashcards
What is the definition of Acute Rhinosinusitis?
Inflammation of the mucosal lining of nasal passages and paranasal sinuses lasting up to 4 weeks, caused by allergens, environmental irritants, and/or infection (viruses, bacteria or fungi)
What is the definition of acute bacterial rhinosinusitis?
Secondary bacterial infection of the paranasal sinuses, usually following viral URI. Less than 2%. Not common.
What is the most common gram positive organism that cause ABRS?
S. pneumoniae
What is the most common gram negative organism that causes ABRS?
H. influenzae
What is the second most common gram negative organism that causes ABRS?
M. catarrhalis
What are the most common features of acute bacterial rhinosinusitis?
fever and symptom duration of more than 10 days (discharge, malaise)
Maxillary toothache
Initial symptom improvement and then worsening of symptoms
Cacosmia (sense of bad odor in nose)
Unilateral facial pain
What is the initial therapy for ARBS?
Amoxicillin 500 mg TID or Amoxicillin-clavulanate PO BID
What is the initial therapy for ARBS in beta-lactam allergy?
Cefdinir 600 mg/day
Cefpodoxime 200 mg PO
Cefuroxime
Floxacin (if allergy)
What is the therapy for ARBS if treatment failure after 3-5 days of therapy?
Mild/ moderate: Augmentin 2000mg/125 mg PO BID or
2nd or 34rd gen cephalosporin (cefpodoxime, cefprozil, cefdinir)
Severe: levofloxacin 750 mg PO daily or Moxifloxacin 400 mg PO daily
What is the most common drug Substrate that causes interactions?
CYP450: Viagra, atorvastatin, simvastatin, alprazolam
What is a substrate?
A medication or substrate that is metabolized/bio transformed by the isoenzyme, utilizing this enzyme in order to be modified so it can reach the drug site of action and/or eliminated
What is an inhibitor?
A drug or other substance that blocks the activity of the isoenzyme, limiting substrate excretion, allowing increase in substrate levels, with possible risk of substrate- induced toxicity
What are common drug inhibitors?
Erythromycin, clarithromycin
What is a drug inducer?
Accelerates the activity of the isoenzyme so that the substrate is pushed out the exit pathway, leading to a reduction in substrate level
What is an example of drug inducer??
St. John’s Wort
leads to reduced target drug levels and diminished therapeutic effect, possible treatment failure
Is weber test conductive or sensiornueral?
Conductive (sound is blocked)
Is Rhine test conductive or sensiornueral?
Sensorineural (inner ear or nerve damage)
What is the first line intervention for allergic rhinitis?
1st line = avoid the allergen
What is the controller therapy to prevent symptoms of allergic rhinitis?
Intranasal corticosteroids (INCS)
Intranasal antihistamine (IAH)
What is the reliever therapy of acute allergic rhinitis?
2nd generation oral antihistamines
Ocular antihistamines for allergic conjunctivitis signs and symptoms
Characteristic of infectious nodes
soft/ tender- infection