CHAPTER 4: Adaptive Immunity Flashcards
Which MHC molecule is necessary for antigen recog-nition by CD4+ T cells?
a. Class I
b. Class II
c. Class III
d. No MHC molecule is necessary.
b. Class II
Which would be characteristic of a T-independent antigen?
a. The IgG antibody is produced exclusively.
b. A large number of memory cells are produced.
c. Antigens bind only one receptor on B cells.
d. It consists of a limited number of repeating determinants.
d. It consists of a limited number of repeating determinants.
Humoral immunity refers to which of the following?
a. Production of antibody by plasma cells
b. Production of cytokines by T cells
c. Elimination of virally infected cells by cytotoxic cells
d. Downregulation of the immune response
a. Production of antibody by plasma cells
Where does antigen-independent maturation of B lymphocytes take place?
a. Bone marrow
b. Thymus
c. Spleen
d. Lymph nodes
a. Bone marrow
In the thymus, positive selection of immature T cells is based upon recognition of which of the following?
a. Self-antigens
b. Stress proteins
c. MHC antigens
d. µ chains
c. MHC antigens
Which of these are found on a mature B cell?
a. IgG and IgD
b. IgM and IgD
c. Alpha and beta chains
d. CD3
b. IgM and IgD
How do cytotoxic T cells kill target cells?
a. They produce antibodies that bind to the cell.
b. They engulf the cell by phagocytosis.
c. They stop protein synthesis in the target cell.
d. They produce granzymes that stimulate apoptosis.
d. They produce granzymes that stimulate apoptosis.
Which of the following can be attributed to antigen-stimulated T cells?
a. Humoral response
b. Plasma cells
c. Cytokines
d. Antibody
c. Cytokines
Which is a distinguishing feature of a pre-B cell?
a. µ chains in the cytoplasm
b. Complete IgM on the surface
c. Presence of CD21 antigen
d. Presence of CD25 antigen
a. µ chains in the cytoplasm
When does genetic rearrangement for coding of antibody light chains take place during B-cell development?
a. Before the pre-B cell stage
b. As the cell becomes an immature B cell
c. Not until the cell becomes a mature B cell
d. When the B cell becomes a plasma cell
b. As the cell becomes an immature B cell
Which of the following antigens are found on the T-cell subset known as helper/inducers?
a. CD3
b. CD4
c. CD8
d. CD11
b. CD4
Where does the major portion of antibody production occur?
a. Peripheral blood
b. Bone marrow
c. Thymus
d. Lymph nodes
d. Lymph nodes
Which of the following would represent a double-negative thymocyte?
a. CD2-CD3+CD4-CD8+
b. CD2-CD3-CD4+CD8-
c. CD2+CD3+CD4-CD8-
d. CD2-CD3-CD4+CD8-
c. CD2+CD3+CD4-CD8-
Which of the following best describes the T-cell receptor for antigen?
a. It consists of IgM and IgD molecules.
b. It is the same for all T cells.
c. It is present in the double-negative stage.
d. Alpha and beta chains are unique for each antigen.
d. Alpha and beta chains are unique for each antigen.
A cell flow cytometry pattern belonging to a 3-year-old patient showed the following: normal CD4+ T-cell count, normal CD19+ B-cell count, low CD8+ T-cell count. Which type of immunity would be affected?
a. Production of antibody
b. Formation of plasma cells
c. Elimination of virally infected cells
d. Down regulation of the immune response
c. Elimination of virally infected cells
