CHAPTER 15: Autoimmunity Flashcards
All of the following may contribute to autoimmunity except
a. clonal deletion of self-reactive T cells.
b. molecular mimicry.
c. increased expression of class II MHC antigens.
d. polyclonal activation of B cells.
a. clonal deletion of self-reactive T cells.
Which of the following would be considered an organ-specific autoimmune disease?
a. SLE
b. RA
c. GPA
d. Hashimoto’s thyroiditis
d. Hashimoto’s thyroiditis
SLE can be distinguished from RA on the basis of which of the following?
a. Joint pain
b. Presence of antinuclear antibodies
c. Immune complex formation with activation of complement
d. Presence of anti-dsDNA antibodies
d. Presence of anti-dsDNA antibodies
Which of the following would support a diagnosis of drug-induced lupus?
a. Antihistone antibodies
b. Antibodies to Smith antigen
c. Presence of RF
d. Antibodies to SS-A and SS-B antigens
a. Antihistone antibodies
A peripheral pattern of staining of the nucleus on IIF is caused by which of the following antibodies?
a. Anti-Sm antibody
b. Anti-SSA/Ro antibody
c. Centromere antibody
d. Anti-dsDNA
d. Anti-dsDNA
Which of the following would be considered a significant finding in Graves disease?
a. Increased TSH levels
b. Antibody to TSHR
c. Decreased T3 and T4
d. Antithyroglobulin antibody
b. Antibody to TSHR
Destruction of the myelin sheath of axons caused by the presence of antibody is characteristic of which disease?
a. MS
b. MG
c. Graves disease
d. Goodpasture’s syndrome
a. MS
Blood was drawn from a 25-year-old woman with suspected SLE. A FANA screen was performed and a speckled pattern resulted. Which of the following actions should be taken next?
a. Report out as diagnostic for SLE
b. Report out as drug-induced lupus
c. Perform an assay for specific ANAs
d. Repeat the test
c. Perform an assay for specific ANAs
Which of the following is a mechanism used to achieve peripheral tolerance?
a. Negative selection of autoreactive T cells in the thymus
b. Apoptosis of autoreactive B cells in the bone marrow
c. Editing of B-cell receptors that weakly recognize self-antigens in the bone marrow
d. Lack of a costimulatory signal to autoreactive T cells in the lymph nodes
d. Lack of a costimulatory signal to autoreactive T cells in the lymph nodes
Epitope spreading refers to
a. post-translational modifications to self-antigens.
b. modifications in gene expression that are not caused by changes in DNA sequence.
c. expansion of the immune response to unrelated antigens.
d. cross-reaction of the immune response to a pathogen with a similar self-antigen.
c. expansion of the immune response to unrelated antigens.
Anti-CCP (cyclic citrullinated proteins) is specifically associated with which autoimmune disease?
a. RA
b. MG
c. Autoimmune hepatitis
d. Goodpasture’s syndrome
a. RA
Which autoantibodies are strongly associated with granulomatosis with polyangiitis (Wegener’s granulomatosis)?
a. ANA
b. ANCA
c. AMA
d. SMA
b. ANCA
A technologist performs an IIF test for ANCAs and observes that there is an intense fluorescent staining of the nuclear lobes of the neutrophils. How can this type of staining be differentiated from a peripheral ANA pattern?
a. Perform the test on formalin-fixed leukocytes
b. Perform IIF with HEp-2 cells
c. Perform an ELISA for ANCAs
d. All of the above
d. All of the above
A 20-year-old woman made an appointment to see her physician because she was experiencing intermittent diarrhea. Laboratory testing revealed that she also had an iron deficiency anemia. To determine if the patient has celiac disease, her doctor should order which of the following laboratory tests?
a. Anti-tTG
b. Antigliadin
c. Antigluten
d. All of the above
a. Anti-tTG
Antimitochondrial antibodies are strongly associated with which disease?
a. Autoimmune hepatitis
b. Celiac disease
c. Primary biliary cirrhosis
d. Goodpasture’s syndrome
c. Primary biliary cirrhosis
