Chapter 4,5,6 Vocab Flashcards
Microelectrodes
Extremely fine recording electrodes, which are used for intracellular recording
Membrane Potential
The difference in electrical charge between the inside and the outside of a cell
Resting Potential
The steady membrane potential of a neuron at rest, usually about -70 mV
Ions
Positively or negatively charges particles
Random Motion
The first of the two homogenizing factors
Contrast X-Ray Techniques
inject into one compartment of the body a substance that absorbs x-rays either less than or more than the surrounding tissue. The substance then heightens the contrast between the compartment and the surrounding tissue during the X-ray photography.
Cerebral Angiography
X-ray technique that uses the infusion of a radio-opaque dye into a cerebral artery to visualize the cerebral circulatory system during X-ray photography.
Computed Tomography
A computer-assisted X-ray procedure that can be used to visualize the brain and the other internal structures of the living body.
Magnetic Resonance Imaging
Procedure in which high-resolution images are constructed from the measurement of waves that hydrogen atoms emit when they are activated by radio-frequency waves in a magnetic field. Provides clearer images than the CT.
Spatial Resolution
Ability to detect differences in spatial location
Concentration Gradients
A concentration gradient occurs where the concentration of something changes over a certain distance
Electrostatic Pressure
Positively charged ions (cat ions) and negatively charged ions (anions) attract each other but repel their own kind
Ion Channels
Ions pass through the neural membrane at specialized pores known as the Ion channels, each type of which is specialized for the passage of particular ions
Hodgkin and Huxley
Neurophysiologists whom provided the first evidence that an energy-consuming process is involved in the maintenance of the resting potential
Sodium-Potassium Pump
Active transport mechanisms that pump Na+ ions out of neurons and K+ ions in
Transporters
Mechanisms in the membrane of a cell that actively transport ions or molecules across the membrane
Depolarize
To decrease the resting membrane potential
Hyperpolarize
To increase the resting membrane potential
Excitatory Postsynaptic Potentials
Graded postsynaptic depolarizations, which increase the likelihood that an action potential will be generated
Inhibitory Postsynaptic Potentials
Graded postsynaptic hyperpolarizations, which decrease the likelihood that an action potential will be generated
Graded Responses
Responses whose magnitude is indicative of the magnitude of the stimuli that will induce them
Axon Hillock
The conical structure at the junction between the axon and cell body
Positron Emission Tomography
Brain-imaging technique that has been widely used in biopsychological research because it provides images of brain activity rather than brain structure.
2-deoxyglucose
Injected into the patient?s carotid artery. Similar to glucose, so it is quickly taken up by active cells. However, it cannot be metabolized and therefore accumulates. Allowing to see what brain structures are active at certain times.
Functional MRI
Produce images of the increase in oxygen flow in the blood to active areas of the brain which allows inferring what brain structure is at work.
BOLD Signal
This is the signal that the functional MRI produces. (blood-oxygen-level- dependent signal)
Magnetoencephalography
Measures changes in magnetic fields on the surface of the scalp that are produced by changes in underlying patterns of neural activity.
Temporal Resolution
An advantage of Magnetoencephalography, the ability to detect differences in time
Electroencephalography
A technique for recording the gross electrical activity of the brain, commonly recorded through scalp electrodes
Transcranial Magnetic Stimulation
Technique for disrupting the activity in an area of the cortex by creating a magnetic field under a coil positioned next to the skull. Stimulation turns off part of the brain while the effects of the disruption on cognition and behavior are assessed.
Alpha Waves
Regular, 8 to 12 second, high amplitude waves that are associated with relaxed wakefulness.
Event Related Potentials
Waves that accompany certain psychological events.
Sensory Evoked Potential
A type of the event related potentials, the change in the cortical EEG signal that is elicited by the momentary presentation of a sensory stimulation.
Signal Averaging
A method used to reduce the noise of the background EEG
Threshold of Excitation
The level of depolarization necessary to generate an action potential, usually about -65 mV
Average Evoked Potentials
Focuses on the various waves in the averaged signal. When presented a stimulus, the average response time. Plotted then the background EEG is canceled.
Action Potential
A massive momentary reversal of a neurons membrane potential from about -70 mV to about +50 mV
P300 Wave
This wave occurs only if the stimulus has meaning for the subject. Ex: gets a reward
All-or-None Responses
Responses that are not graded, that either occur in their full extent or not at all
Far-Field Potentials
The portion of the evoked potential when the stimulus is not influenced by the meaning of the stimulus for the subject.
Integration
Adding or combing a number of individual signals into one overall signal
Electromyography
Usual procedure for the measuring muscle tension.
Spatial Summation
The integration of signals that occur at different sites on the neurons membrane
Electrooculography
Electrophysiological technique for recording eye movement
Temporal Summation
The integration of neural signals that occur at different times at the same synapse
Skin Conductance Level
One of the most common to assess the above. Measure of the background level of skin conductance that is associated with a particular situation
Voltage-Activated Ion Channels
Ion channels that open and close in response to changes in the level of the membrane potential
Skin Conductance Response
One of the electrodermal activity tests, is a measure of the transient changes in the skin conductance that are associated with discrete experiences.
Rising Phase
During the rising phase of an action potential, the membrane potential changes from negative to positive, a depolarization
Electrocardiogram
Recording of the heart beat by placing electrodes on the chest. Average is 70/min
Re-polarization
Re-polarization refers to the change in membrane potential that returns the membrane potential to a negative value after the depolarization phase of an action potential has just previously changed the membrane potential to a positive value
Hypertension
A chronic blood pressure of more than 140/90 mmHg.
Absolute Refractory Period
A brief period after the initiation of an action potential during which it is impossible to elicit another action potential in the same neuron
Sphygmamanometer
Device composed of a hollow cuff, a rubber bulb for inflating, and a pressure gauge. Measures blood pressure.
Relative Refractory Period
A period after the absolute refractory period during which a higher-than-normal amount of stimulation is necessary to make a neuron f ire
Stereotaxic surgery
Brain surgery using a stereotaxic apparatus to position an electrode or cannula in a specified position of the brain
Non-decremental
The conduction of action potentials along an axon
Plethysmography
The various techniques for measuring changes in the volume of blood in a particular part of the body
Antidromic Conduction
Axonal conduction opposite to the normal direction; conduction from axon terminals back toward the cell body
Stereotaxic Atlas
Used to locate brain structure in much the same way a geo atlas. The brain has three dimensions. All distances are measured in millimeters from a designated reference point
Orthodromic Conduction
Axonal conduction in the normal direction-from the cell body toward the terminal buttons
Bregma
A reference point on the stereotaxic atlas, on top of the skull where two of the major sutures intersect.
Nodes of Ranvier
The gaps between adjacent myelin segments on an axon
Stereotaxic Instrument
Has two parts: head holder and the electrode holder. Electrode holder allows to be moved in the three dimensions: anterior-posterior, dorsal-ventral, and lateral-medial.
Saltatory Conduction
Conduction of an action potential from one node of Ranvier to the next along a myelinated axon
Aspiration
The cortical tissue is drawn off by suction through a fine-tipped handleheld glass pipette.
Neurodegenerative Diseases
Diseases that damage the nervous system
Radio-Frequency Current
Small subcortical lesions are made by this technique when high frequency current is passed through the target tissue from the tip of an electrode.
Motor Neurons
Neurons that synapse on skeletal muscles
Knife Cuts
Used to eliminate conduction in a nerve or tract. Tiny cut can accomplish this without extensive damage to surrounding tissue.
Inter-neurons
Passive and decremental conduction
Cryogenic Blockade
When coolant is pumped through an implanted cryoprobe, neurons near the tip are cooled until they stop firing. No structural damage.
Hodgkin-Huxley Model
A mathematical model (a type of scientific model) that describes how action potentials in neurons are initiated and propagated. It is a set of nonlinear ordinary differential equations that approximates the electrical characteristics of excitable cells such as neurons and cardiac myocytes.
Cryoprobe
Probe in the cryogenic blockade technique
Dendritic spines
Tiny nodules of various shapes that are located on the surface of many dendrites and are the sites of most excitatory synapses in the mature mammalian brain
Unilateral Lesion
Lesions restricted to one half of the brain
Axosomatic Synapses
Synapses of each terminal buttons on somas
Bilateral Lesion
Lesions that involving both sides of the brain
Dendrodendritic synapses
Types of synapse that is capable of transmission in either direction
Bipolar Electrode
Stimulates the brain through two insulated wires wound tightly together and cut at the end.
Axoaxonic synapses
Types of synapse that helps mediate presynaptic facilitation and inhabitation
Intracellular Unit Recording
Provides a moment-by-moment record of the graded fluctuations in one neuron?s membrane potential
Presynaptic Facilitation
Axoaxonic synapses that increase effect on one neuron to another
Extracellular Unit Recording
Provides a record of firing of a neuron but no info about the neuron?s membrane potential.
Presynaptic Inhibition
Decreases effects of one neuron to another
Multiple-Unit Recording
Graph of the total number of recorded action potentials per unit of time
Directed Synapses
Synapses at which the site of neurotransmitter release the site of neurotransmitter reception are in close proximity
Invasive EEG Recording
EEG signals are recorded through large implanted electrodes rather than through scalp electrodes. Cortical EEG signals are frequently recorded through stainless steel skull screws whereas subcortical EEG signals are typically recorded through stereotaxically implanted wire electrodes.
Non directed Synapses
Synapses at which the site of neurotransmitter release and the site of neurotransmitter reception are not close together
Intraperitoneally
When drugs are injected hyperodermically into the peritoneal cavity of the abdomen.
String-of-Beads Synapses
String like shaped synapses
Intramuscularly
When drugs are injected into a large muscle
Neuropeptides
Short amino acid chains comprising between 3 and 36 amino acids; in effect they are short proteins
Subcutaneously
When drugs are injected fatty tissue beneath the skin
Synaptic Vesicles
Small spherical membranes that store neurotransmitter molecules and release them into the synaptic cleft
Intravenously
When drugs are injected into large veins
Golgi Complex
Structures in the air cell bodies and terminals buttons of neurons that package neurotransmitters and other molecules in vesicles
Cannula
A fine, hollow tube that has been stereotaxically implanted in the brain
Coexistence
The presence of more than one neurotransmitter in the same neuron
Neurotoxins
Neural poisons
Exocytosis
The process of releasing a neurotransmitter
Autoradiography
When slices of the brain are coated with a photographic emusion, stored in the dark for a few days and then developed much like film. High levels of 2-DG are black spots.
Voltage-Activated Calcium Channels
When stimulated by action potentials, these channels open, and Ca2+ ions enter the button
Cerebral Dialysis
Method of measuring the extracellular concentration of specific neurochemicals in behaving animals. Animal doesn?t need to be killed in this technique.
Receptors
Cells that are specialized to receive chemical, mechanical or radiant signals from the environment; also proteins that contain binding sites for particular neurotransmitters
Chromatograph
A device for measuring the chemical constituents of liquids or gases
Ligand
A molecule that binds to another molecule; neurotransmitters are ligands of their receptors
Antigens
Proteins on the surface cells that identify them as native or foreign
Receptor Subtypes
The different types of receptors to which a particular neurotransmitter can bind
Immunocytochemistry
Procedure for locating particular neuroproteins in the brain by labeling their antibodies with a dye or radioactive element then exposing the slices to the labeled antibodies.
Iontropic Receptors
Receptors that are associated with ligand activated ion channels
In Situ Hybridization
Another technique for locating peptides and other proteins in the brain; molecules that bind to the mRNA that directs synthesis of the target protein are synthesized and labeled, and the brain slices are exposed to them.
Metabotropic Receptors
Receptors that are associated with signal proteins and G protein
Gene Knockout Techniques
Procedures for creating organism that lack a particular gene under investigation
G Proteins
Protein that is attached to a protein of signal protein. Once neurotransmitters binds to meta receptors, sub unit of G protein breaks off or trigger synthesis of 2nd messenger
Antisense Drugs
Helps to circumvent the problems with gene knockout technique, allows for an organism to develop normally but then reaches into their brain and blocks expression of a particular gene.
Second Messenger
A chemical synthesized in a neuron in response to the binding of a neurotransmitter to a metabotropic receptor in its cell membrane