Chapter 37: Drugs Flashcards
reduced BP
beta-adrenergic blockers
increases bleeding with warfarin
fibric acid derivatives
encourage patient taking long-acting nitrates to have a nitrate free time of _________ each day
10-14 hours
reduced HR (2)
beta-adrenergic blockers
calcium channel blockers
makes more of its receptors available to get rid of cholesterol
PCSK9 inhibitors
routes of administration of long-acting nitrates
oral, nitroglycerin (NTG) ointment, transdermal controlled-release NTG
used in patients with an ejection fraction of <40% (2)
angiotensin-converting enzyme (ACE) inhibitors
angiotensin receptor blockers (ARBs)
increases conversion of cholesterol to bile acids
bile acid sequestrants
decreased total cholesterol
bile acid sequestrants
this drug is used with STEMI
glycoprotein IIb/IIIa inhibitors (during PCI)
side effects include dizziness, nausea, constipation, and headache
sodium current inhibitor
is given subcutaneously
PCSK9 inhibitors
side effects include flushing, pruritus, GI symptoms, orthostatic hypotension
niacin
sublingual nitroglycerin (SL NTG) dosage
1 tablet or 1-2 metered sprays
increases effects of antihyperglycemic drugs (repaglinide)
fibric acid derivatives
HMG-CoA reductase inhibitors are also known as
statins
prevents or reverses ventricular remodeling (2)
ACE inhibitors
angiotensin receptor blockers
given in patients with a history of MI or LVH
beta-adrenergic blockers
reduced cardiac volume (2)
ACE inhibitors
angiotensin receptor blockers
used to reduce frequency of angina and treat Prinzmetal’s angina
long-acting nitrates
reduced SVR (2)
beta-adrenergic blockers
calcium channel blockers
increased risk for rhabdomyolysis when used with fibric acid derivatives, niacin, or erythromycin
simvastatin
increased HDL (3)
statins
niacin
fibric acid derivatives
inhibits cholesterol synthesis
statins
SL NTG may be repeated every ___ minutes up to __ doses
5, 3
reduced myocardial contractility (2)
beta-adrenergic blockers
calcium channel blockers
decreased C-reactive protein
statins
can cause cough, angioedema
ACE inhibitors
decreases absorption of dietary and biliary cholesterol; combined with statin
ezetimibe
may cause headache, dizziness, flushing, orthostatic hypotension
sublingual nitroglycerin (SL NTG)
has GI side effects and reduced absorption of other drugs (thiazides, warfarin, digoxin)
bile acid sequestrants
known to cause constipation
verapamil
side effects include bradycardia, hypotension, wheezing, GI effects, weight gain, depression, fatigue, sexual dysfunction
beta-adrenergic blockers
dilate peripheral and coronary arteries and collateral vessels
short-acting nitrates
decreased LDL (2)
statins
bile acid sequestrants
SL NTG gives relief in __ minutes and lasts _____ minutes
5, 30-40
side effects include fatigue, headache, dizziness, flushing, peripheral edema
calcium channel blockers (CCBs)
monitor this enzyme for myalgia
CK-MM
inhibits synthesis of triglycerides
niacin
inhibits synthesis of LDL
niacin
vasodilation (4)
ACE inhibitors
angiotensin receptor blockers
calcium channel blockers
nitrates
contraindicated in patients with severe bradycardia and acute decompensated heart failure
beta-adrenergic blockers
monitor when using digoxin
calcium channel blockers (CCBs)
most potent statin
rosuvastatin (Crestor)
used when inadequate response to other antianginal drugs
sodium current inhibitor
these two drugs are used with UA and NSTEMI
heparin
glycoprotein IIb/IIIa inhibitors (before or during PCI)
two serious adverse effects of rosuvastatin
liver damage, myalgia
used with diet therapy and maximum statins
PCSK9 inhibitors
cautious use of this medication with asthma and diabetes
beta-adrenergic blockers
decreased triglycerides
fibric acid derivatives