Chapter 36

Question 1

first antivirals introduced in

Answer 1

1960

Question 2

chemotherapy focuses on

Answer 2

HIV and other viruses with no effetive vaccines

Question 3

testing different chemicals ->

Answer 3

amantadine and acyclovir

Question 4

testing other chemicals with similar structures to those that worked ->

Answer 4

ganciclovir and azidothymidine

Question 5

target-based high-throughput screens

Answer 5

nevirapine

Question 6

designer drugs ->

Answer 6

ritonavir and zanamivir

Question 7

attachment step target

Answer 7

Pleconaril (picornaviruses)

Maraviroc (HIV)

Question 8

entry step target

Answer 8

Enfuvirtide (HIV)

Question 9

uncoating step target

Answer 9

Amantadine (influenza A)

Question 10

replication of viral genome

Answer 10

Acyclovir (herpesviruses)
Ganciclovir (cytomegalovirus)
Nevirapine (HIV)
Raltegravir (HIV)

Question 11

maturation

Answer 11

Ritonavir (HIV)

Oseltamivir (influenza A and B)

Question 12

release

Answer 12

zanamivir (influenza A and B)

Question 13

Maraviroc binds to

Answer 13

CCR5: prevents attachment, approved 2007

Question 14

Enfuvirtide blocks

Answer 14

HIV gp41 conformation change: prevents fusion, approved 2003

Question 15

Pleconaril displaces

Answer 15

lipid in canyon of VP1: prevents attachment or entry, not approved

Question 16

Amantadine blocks

Answer 16

ion channel M2: inhibits uncoating of influenza virus, approved

Question 17

Acyclovir, Ganciclovir are

Answer 17

nucleoside analogues: inhibit viral DNA pols HSV, being competitive inhibitor, chain terminator

Question 18

AZT are

Answer 18

nucleoside analogues: inhibit viral DNA pols of HIV-1