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BIOL 3155 > Chapter 12 > Flashcards

Chapter 12 Flashcards

Flavivirus

1
Q

The basic structure of flavivirus

A

enveloped icosahedral with T=3 capsid, (+) ss-RNA with 1 C protein and 2 enveloped proteins (E and M)

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2
Q

E is for

A

attachment and fusion

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3
Q

Yellow fever virus (flavivirus)

A

monkeys and humans; hemorrhagic fever

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4
Q

Dengue (types1-4) virus (flavivirus)

A

monkeys and humans; fever, arthralgia, rash, hemorrhagic fever

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5
Q

West Nile virus (flavivirus)

A

birds and humans; fever, arthralgia, rash

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6
Q

Bovine viral diarrhea (Pestivirus)

A

Ruminants; persistent infection, mucosal disease

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7
Q

Hepatitis C (Hepacivirus)

A

humans, acute and chronic hepatitis

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8
Q

mosquitoes are anthropod vector to

A

yellow fever, dengue, and west nile viruses

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9
Q

yellow fever virus is controlled via

A

vaccination with live attenuated by Theiler

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10
Q

Dengue virus originates in

A

tropics

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11
Q

West Nile virus is in

A

North America since 1999

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12
Q

Yellow fever virus has three stages in symptom progression

A

1) high fever, muscle pain, headache, and severe vomiting; 2) latent stage of fever dissipating; 3) repeat of original symptoms with more severity

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13
Q

the genome structure of the flavivirus is

A

linear (+) ss-RNA with 5’ cap structure and no poly(A) tail

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14
Q

the genome structure of the pestivirus and hepacivirus is

A

no 5’ cap IRES instead and no poly(A) tail

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15
Q

yellow fever genome has

A

structural C, prM, E; non-structural NS1, 2A, 2B, 3, 4A, 4B, 5

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16
Q

the genome is taken steps of

A

from one ORF to one polyprotein to 10 mature proteins

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17
Q

the structural proteins of YFV are

A

anchC -> C, prM -> M, E

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18
Q

anchC is

A

“anchored” capsid protein. precursor to capsid protein; signal sequence inserted in membrane is cleaved by viral proteinase

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19
Q

C’s function is

A

encapsidation of genome RNA

20
Q

prM’s function is

A

binding to E glycoprotein, inhibiting membrane fusion during transit through Golgi. cleaved to produce mature M protein, releasing pr.

21
Q

M is

A

small envelope glycoprotein. Function in the mature virion is unknown.

22
Q

E is

A

major envelope glycoprotein. receptor binding, fusion of virus envelope with cell membrane

23
Q

viral protease “NS2B-NS3” cleaves

A

c from AncC

24
Q

cellular signal peptidase cleaves

A

between AncC and M, M and E, E and NS1

25
Q

cellular furin protease cleaves

A

prM-E to pr+M and E-E for maturation process

26
Q

E protein is

A

type-1 transmembrane that forms head-to-tail dimer

27
Q

E-protein dimer turns into trimer before

A

fusion

28
Q

Domain III and I have

A

N and C terminus, and is for attachment

29
Q

fusion protein is located at

A

fusion peptide near domain II and III, which is hydrophobic and ph-dependent

30
Q

the nonstructural proteins of YFV are

A

NS1, 2A, 2B, 3, 4A, 4B, 5

31
Q

NS1 is

A

RNA replicase component, possibly involved in replication complex formation

32
Q

NS2A is

A

RNA replicase complex, either direct role in replication or targeting replicase complex to membranes

33
Q

NS2B is

A

part of viral proteinase that cleaves viral polyprotein

34
Q

NS3 is

A

viral serine proteinase involved in polyprotein cleavage; RNA replicase component; nucleoside triphophatase and helicase activites

35
Q

NS4A is

A

RNA replicase component, may recruit NS1 and other proteins into replicase complex

36
Q

NS4B is

A

unknown for role. Associated with membranes in cytoplasm; may translocate to nucleus

37
Q

NS5 is

A

RdRp; methyltrasnferase that methlylates cap structure

38
Q

RNA replicase complex assembles on

A

outer ER membranes

39
Q

After endocytosis, E-E turns into

A

E-E-E

40
Q

Virus fusion and disassembly is depended on

A

the low pH within a late endosome, promoting the fusion of viral and cellular membrane by the E protein

41
Q

RNA is released to

A

the cytoplasm

42
Q

protein translation of the RNA leads to

A

the establishment of membrane-bound RNA replication factories

43
Q

membrane-bound RNA replication factories are spatially linked to

A

sites of assembly and budding of immature virus on membrane of the ER

44
Q

the immature virus is

A

glycosylated and traverses the secretory network

45
Q

in the trans-Golgi network, the low pH promotes

A

the folding of the spike-containing immature particles into the semi-mature state and permits the cleavage of prM by host furin protease

46
Q

release of the virions into the ECM results in

A

release of the pr protein and a fully infectious mature virions

BIOL 3155 (16 decks)

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