Chapter 3 Cells Flashcards
Human cells have 3 basic parts:
Plasma membrane, cytoplasm, nucleus
The study of cells
Cytology
What kind of bilateral is the plasma membrane?
Phospholipid
Plasma membrane structure
Dynamic fluid structure, is selectively permeable, seperated intercellular fluid (ICF) from extracellular fluid (ECF)
Membrane lipids
75% phospholipids
5% glycolipids
20% cholesterol
Phospholipids parts
Polar Hydrophilic phosphate heads and unipolar hydrophilic fatty acid tails
Define Glycolipids
Lipids with sugar groups, cell identification
Membrane proteins
Integral and peripheral proteins
Integral protiens
Firmly inserted in membrane, mostly transmembrane protiens
Peripheral protiens
Loosely attached to integral protiens
Define glycocalyx
Fuzzy stick “sugar covering” at cell surface (glycolipids and glycoproteins
Acts as biological market allowing cells to recognize eachother
Cell junctions
Tight junctions
Desmosomes
Gap junctions
Tight junction
Impermeable junctions that prevent molecules from passing through intercellular space, in lining of intestines
Desmosomes
Anchoring junctions to prevent desperation of cells and withhold mechanical stress
Gap junction
Communication junction that allow small molecules to pass from cell to cell, cardiac muscle & smooth muscle
Passive transport
Does not use ATP
Diffusion
Movement of molecules down their concentration gradient
Different diffusions
Simple diffusion
Facilitied diffusion
Simple diffusion
diffusion of solutes through plasma membrane without using a channel or carrier
Speed of a molecule is determined by
Size and temp and concentration gradient
Carrier mediated
Sugars and amino acids are moved through membrane via protein carriers
Channel mediated
Ions and water are moved through membrane via protein channels
Osmosis
Diffusion of a solvent through selectively permeable membrane, water moves from a solution with a higher concentration to a solution with lower concentration
Osmolarity
Measure of total concentration of solute particles in a solution
Isotonic solution
Solution with same solute concentration as a cellular fluid
Hypertonic solution
Solution with higher solute concentration than cellular fluid
Hypertonic solution
Solution with lower solute concentration than cellular fluid
Cells lose water and shrink if exposed to a
Hypertonic solution
Cells gain water and swell if exposed to a
Hypotonic solution
Active processes
Uses ATP to move substances across membrane
Active transport
Both primary and secondary active transport uses solute pumps to move substances against a concentration gradient
Primary active transport
Energy used to transfer molecules is directly from ATP
Secondary active transport
Energy used to transport molecules is from energy stored in ionic gradients created by primary active transport
Vesicular transport
Uses membraneous sacs to transport particles, macromolecules, and fluids across the plasma membrane or within the cell
Endocytosis
Transport into the cell
Phagocytosis
Endocytosis in which large, solid materials are brought into the cell
Pinocytosis
Endocytosis in which a small volume of extra cellular fluid with dissolved solutes is taken into a cell
Receptor-mediated endocytosis
Endocytosis in which specific substances bind to receptor protiens and are ingested
Membraneous sacs in vesicular transport
Vesicles
Transcytosis
Transport into, across, then out of cell
Vesicular trafficking
Transport from one area in the cell to another
Exocytosis
Transport out of cell
What does RMP stand for
Resting membrane potential
Resting membrane potential
A condition in which the inside of the cell membrane is negatively charged compared to the positively charged outside
The RMP ranges from
-50 to -100 mV
RMP is mainly determined by what
Concentration gradient of potassium
RMP is maintained by what
Active transport pumps
Major positive ion inside cell
Sodium
Major positive ion inside cell
Potassium
Cytoplasm
Cellular material between the cell membrane and the nucleus
Three major elements of cytoplasm
Cytolsol
Organelles
Inclusions
Cytolsol
Water with solutes (protien, salts, sugars)
Organelles
Metabolic machinery of cell; specialized function; membraneous or nonmembraneous
Inclusions
Vary with cell type; eg glycogen granules, pigments
Mitochondria
Membraneous organelles that produce most of the ATP for a cell via aerobic cellular respiration; contain their own DNA, RNA, and ribosomes, can do cell division
Ribosomes
Small granules consisting of ribosomal RNA and protien; site of protein synthesis
Endoplasmic reticulum (ER)
Extensive system of tubes and membraneous throughout cytosol enclosing fluid filled cavities
Fluid filled cavities in ER
Cisterns
Rough ER
Has ribosomes that synthesis all protiens for secretion and all plasma membrane protiens
Smooth ER
Continuation of rough ER, looping network of tubules; no ribosomes; it’s enzymes function in lipid and steroid synthesis and drug detoxification
Golgi apparatus
Series of membraneous sacs associated with membraneous vesicles
Golgi apparatus function
Modify, concentrates, and packages protiens and lipids made at ER
Peroxisomes
Membraneous sacs containing enzymes, detoxifies harmful substances
Lysosomes
Membraneous sacs containing digestive enzymes, digest warn out organelles, ingested bacteria, viruses, and toxins
Three types of cytoskeleton
Microfilaments
Intermediate filaments
Microtubules
Cytoskeleton
Series of rods and fibers that run throughout the cytosol, supporting cellular structures and aiding in cell movement
Microfilaments
Made from protien actin (also called actin filaments)
Intermediate filaments
Tough protien fibers constructed like ropes
Microtubules
Hollow tubes made from tubulins; form centrioles, cilia, and flagella
Centerosome
A region near the nucleus that functions to organize microtubules and the mitotic spindle
Centrioles
Small, barrel shaped organelles associated with the centrosome
Cilia
Whiplike extensions that move substances across body surfaces
Flagella
Long projections that move whole cells (sperm cell)
Microvilli
Finger like extensions of membrane that increase surface area
Nucleus
Largest organelle, contains DNA
Three regions of nucleus
Nuclear envelope, chromatin, nucleolus (ribosome factory)
One nucleus
Uninucleate
Several nuclei
Multinucleate
Zero nucleus
Anucleate
Meiosis
Cell division producing gametes (sperm cells)
Mitosis
Cell division producing identical daughter cells
Cell cycle
Series of changes a cell goes through from the time it is formed to the time it reproduces
Two main periods of the cell cycle
Interphase (g1, s, g2) and mitotic phase
DNA replication
Prior to cell divison the cell makes a copy of DNA. Each DNA molecule is composed of one old and one new strand
Cell divison
Mitosis (prophase, metaphase, anaphase, telophase)
Cytokenenscus
Division of cytoplasm
Master blueprint for the structure of all protiens that the body synthesizes are found on the
DNA
Segment of DNA with blueprint for one polypeptide chain is called a
Gene
Protien synthesis occurs in 2 steps
Transcription
Translation
Transcription
DNA information is coded into mRNA (takes place in nucleolus)
Translation
mRNA is decided to assemble a protien (in cytoplasm)
Three major forms of RNA (ribonucleic acid)
mRNA
tRNA
rRNA
mRNA
Long nucleotide stands that defect the exact nucleotide sequence of DNA, provides a three base sequence that provides the genetic information needed for protien synthesis
tRNA
Short RNA molecule that transfers amino acids to the ribosomes, contains three based sequence complementary to mRNA
rRNA
Large and small subunits that combine to form ribosomes
In tRNA three based sequence
Anticodon
Three based sequence in mRNA
Codons
Each codon is specific for ___ amino acid
One
Aquaporins (AQPs)
Water moves through these channels
Hydrostatic pressure
The back pressure exerted by water against the membrane
Osmotic pressure
The tendency of the water to move into the cell by osmosis
Tonicity
The ability of a solution to change the shape or tone if cells by altering the cells internal water volume
Solute pumps
Move solutes
Symport system
In secondary active transport the two transported substances move in the same direction
Antiport system
In secondary active transport the two transported substances move in the opposite direction
Phagocytosis
Cell engulfs a large or solid material then digests it
All cells are
Polarized
Cell adhesion molecules (CAMS)
Embryonic development and wound repair and immunity
Ligands
Chemicals that bind specifically to plasma membrane receptors
Endomembrane system
System of organelles that work together to produce, grade, store, export biological molecules and degrade potentially harmful substances
Autolysis
When the cell digests itself
Chromatin is composed of
30% DNA
60% histone proteins
10% RNA
How is DNA made
Replication bubble forms, the older strand goes with the new and starts creating DNA, leading strand is synthesized continuously while the lagging strand is in segments