Chapter 3: Cells Flashcards

1
Q

what are the 3 main parts of a cell

A
  1. plasma membrane
  2. cytoplasm
  3. nucleus
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2
Q

plasma membrane

A

Forms the cells flexible out surface, separating the cells internal environment (inside the cell) from the external environment (outside the cell)

selective barrier: regulates flow of materials in and out of the cell

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3
Q

Cytoplasm

A
  • Consists of all the cellular contents between the plasma membrane and the nucleus
  • Two components: cytosol and organelles
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4
Q

cytosol

A

fluid portion of cytoplasm, contains water, dissolved solutes, and suspended particles
- constitutes 55% of total cell volume
- site of many chemical reactions

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5
Q

Nucleus

A
  • Large organelle that houses most of the cells DNA
  • Contains hereditary units called genes that control cellular structure and function
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6
Q

fluid mosaic model

A

describes the plasma membrane
- Resembles an ever moving sea of fluid lipids that contain a mosaic of many different proteins

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7
Q

Lipid bilayer

A

structural framework - two back-to-back layers made up of three types of lipid molecules—phospholipids, cholesterol, and glycolipids

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8
Q

Phospholipids

A

About 75% of the membrane lipids

Polar: “head” – which is hydropobic (hydro =water phallic = loving)
Nonpolar: hydrophobic (-phobic = fearing)

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9
Q

Amphipathic

A

molecules, which means that they have both polar and nonpolar parts

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10
Q

Integral proteins

A

extend into or through the lipid bilayer among the fatty acid tails and are firmly embedded in it

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11
Q

Transmembrane proteins

A

which means that they span the entire lipid bilayer and protrude into both the cytosol and extracellular fluid

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12
Q

peripheral proteins

A

associate more loosely with the polar heads of membrane lipids or with integral proteins at the inner or outer surface of the membrane

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13
Q

glycoproteins

A

proteins with carbohydrate groups attached to the ends that protrude into the extracellular fluid

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14
Q

functions of membrane proteins

A
  • ion channels
  • carriers
  • receptors
  • enzymes
  • linkers
  • cell identity markers
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15
Q

ion channels

A

(integral)
o Selective
o Form pores or holes through which specific ions, such as potassium can flow to get across the membrane

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16
Q

Carriers

A

(integral)
o Selectively moving a polar substance or ion across the membrane
o Known as transporters

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17
Q

Receptors

A

(integral)
o Serve as recognition sites
o Each is bound by a specific type of molecule
o Molecule that binds to a receptor is called a ligand of that receptor

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18
Q

Enzymes

A

(integral & peripheral)
Catalyze specific chemical reactions at the inside or outside surface of the cell

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19
Q

Linkers

A

(integral & peripheral)
Anchor proteins in the plasma membrane of neighbouring cells to one another or to protein filaments

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20
Q

Cell Identity Markers

A

(glycoproteins)

o may enable a cell to recognize other cells of the same kind during tissue formation or to recognize and respond to potentially dangerous foreign cells

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21
Q

Membrane Fluidity

A

allows interactions to occur within the plasma membrane, such as the assembly of membrane proteins

  • enables movement of membrane components responsible for cellular processes such as growth, secretion
  • allows lipid bilayer to self seal if torn or punctured
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22
Q

Organelles

A

tiny specialized structures within the cell that have characteristics shapes: they perform specific functions in cellular growth, maintenance and reproduction

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23
Q

Nucleus

A

spherical or oval shapes organelle that is usually the most prominent feature of a cell
* Contains most of the cells DNA

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24
Q

Nuclear envelope

A

double membrane that separates the nucleus from the cytoplasm

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25
Nucleus pores
extend through the nuclear envelope * Allow certain substances to move between the nucleus and the cytoplasm
26
Nucleoli
present inside the nucleus * Sites of synthesis of rRNA and assembly of rRNA and proteins into ribosomal subunits
27
Chromatid
In cells that are not dividing, the DNA in the nucleus is associated with proteins to form a diff use mass of fi ne threads
28
Chromosomes
cell division takes place, the DNA replicates (duplicates) and the loops condense even more to form short, thick structures
29
Sister chromatids
a single chromosome consists of a pair of identical strands, they are connected at a region called the centromere
30
1) transcription
o information encoded in a specific region of DNA is copied into a specific molecule of RNA o occurs in nucleus
31
2) translation
- the RNA attaches to a ribosome, where the information contained in RNA is used to direct the assembly of amino acids into a protein - occurs in the cytoplasm
32
Genetic code
set of rules that relate the base triplet sequence of DNA to the corresponding codons of RNA and the amino acids they specify
33
Codon
Each DNA base triplet is transcribed into RNA as a complementary sequence of three nucleotides
34
what 3 types of RNA are made from the DNA template during transcription
1. Messenger RNA (mRNA) * Directs the synthesis of a protein 2. Ribosomal RNA (rRNA) * Joins with ribosomal proteins to make ribosomes 3. Transfer RNA (tRNA) * Binds to amino acid and holds it in place on a ribosome until it is incorporated into a protein during translation
35
what are the stop codons:
UAA, UAG, UGA
36
Somatic cell division
Cell undergoes a nuclear division called mitosis and a cytoplasmic division called cytokinesis to produce two identical cells, each with the same number and kind of chromosomes as the original cell
37
Reproductive cell division
o Mechanism that produces gametes, cells needed to form the next generation of sexually producing organisms o Meiosis: number of chromosomes is reduced by half , and cytokinesis
38
Cell cycle
orderly sequence of events by which a somatic cell duplicates its contents and divides in two 1. Interphase phase (when cell is not dividing) 2. Mitotic phase (when cell is dividing)
39
G1 Phase (preparation phase)
o Interval between the mitotic phase and S phase o Cell is metabolically active o Organelles and cytoplasmic components replicate, but DNA does not. o Duration: 8–10 hours (varies in different cell types).
40
S Phase (DNA replication)
o DNA is copied, so each new cells will have an identical set of genetic material o Each DNA strand uncoils, and new bases pair with the old ones to create two identical DNA molecule o Duration: about 8 hours
41
G2 Phase (second growth phase)
o Cell grows more and prepares for division o Enzymes and proteins needed for cell division are produced o Centrosome replication is completed o Duration: 4-6 hours
42
Question: when does cytokinesis begin?
MITOTIC PHASE
43
Prophase (preparation phase)
o DNA condenses into visible chromosomes o Each chromosome has 2 identical sister chromatid o Mitotic spindle forms and moves to opposite poles o Nuclear envelope disappears
44
Metaphase (middle phase)
o Chromosomes line up in the middle of the cell o Middle area is called: metaphase plate
45
Anaphase (apart phase)
o Centromeres split, and sister chromatids separate o Chromatids move to opposite poles, pulled by the mitotic spindle o Chromosomes look V-shaped as they are dragged
46
Telophase (final phase)
o Chromosomes uncoil back into chromatin (thread like form) o Nuclear envelope reforms around each set of DNA o Nucleolus reapers, and the spindle disappears
47
PMAT = Prophase, Metaphase, Anaphase, Telophase
P = Prepare (DNA condenses, spindle forms) M = Middle (Chromosomes line up) A = Apart (Sister chromatids separate) T = Two nuclei form
48
cytokinesis
is the final step of cell division, where the cytoplasm of a single cell splits into two separate daughter cells
49
Cells 3 possible destinies:
1. Remain alive and functioning without dividing 2. To grow and divide 3. To die
50
cyclin-dependent protein kinases (Cdks)
transfer a phosphate group from ATP to a protein to activate the protein; other enzymes can remove the phosphate group from the protein to deactivate it
51
apoptosis
an orderly, genetically programmed death. a triggering agent from either outside or inside the cell causes “cell-suicide” genes to produce enzymes that damage the cell in several ways, including disruption of its cytoskeleton and nucleus. NORMAL
52
necrosis
is a pathological type of cell death that results from tissue injury
53
Microvilli
increases surface area – common in epithelial cells that line the small intensities, where the large surface area speeds the absorption of digested food
54
how do cells differ in size and shape
o Vary in size o Shapes: round, oval, flat, cube shaped, column shaped, elongated, star shaped, disc shaped - Related to its function in the body
55
1. EPITHELIAL TISSUE
* Covers body surfaces, lines hollow organs and ducts and forms glands * Consist of closely packed cells with little extracellular material between them
56
two major types of epithelial tissue:
1) Covering and lining epithelium o Forms the outer covering of the skin and some internal organs o Lines the lumen (interior space) of hollow structures such as blood vessels, ducts and organs 2) Glandular epithelium o Makes up the secreting portion of glands
57
Secretion of endocrine glands
enter the interstitial fluid and then diffuse directly into the bloodstream without flowing through a duct - sweat, oil, saliva, milk, digestive enzymes
58
Hormones
regulate many metabolic and physiological activities to maintain homeostasis
59
major functions of epithelial tissue
1) Physical barrier that protects against harmful agents in the environment 2) Secretes substances onto the body surface or into hollow organs or blood 3) Absorbs material into the bloodstream or lymph
60
Connective Tissue
Functions: 1) Binds together, supports, strengthens other body tissues 2) Protects and insulates internal organs 3) Major transport system within the body 4) Primary location of stored energy 5) Main source of immune responses two basic elements - extracellular matrix - cells
61
3 protein fibers can be embedded in extracellular matrix:
1. Collagen fibers o Very strong and resist pulling forces o Chemically, they consist of the protein collagen 2. Elastic fibers o Smaller in diameter o Consists of molecules of a protein called elastin surrounded by a glycoprotein o Have elasticity property 3. Reticular fibers o Consisting of collagen and a coating of glycoprotein o Provide support and strength
62
Ground substance
material between the cells and the fibers of connective tissue (can be fluid, gel or solid) * Supports cells, binds them together, stores water
63
Fibroblasts
present in several connective tissues and usually are the most numerous. They migrate through the connective tissue, secreting the fibers and ground substance of the extracellular matrix.
64
Macrophages
develop from monocytes, a type of leukocyte. They are capable of engulfing bacteria and cellular debris by phagocytosis, a form of endocytosis
65
Plasma cells
small cells that develop from a type of leukocyte called a B lymphocyte. Plasma cells secrete antibodies, proteins that attack or neutralize foreign substances in the body. Thus, plasma cells are an important part of the body’s immune response.
66
Mast cells
abundant alongside blood vessels that supply connective tissue. They produce histamine, a chemical that dilates blood vessels as part of the inflammatory response, the body’s reaction to injury or infection.
67
Adipocytes
also called fat cells or adipose cells, are connective tissue cells that store triglycerides ( fats). They are found below the skin and around organs such as the heart and kidneys.
68
Muscle Tissue: 3 types
* Elongated cells called muscle fibers that are highly specialized to contract * Classified into three types: 1) Skeletal muscle o is usually attached to bones of the skeleton and is responsible for producing movement, maintaining posture, and generating heat. 2) Cardiac muscle o forms the bulk of the heart wall; its rhythmic contractions pump blood to all parts of the body 3) Smooth muscle o located in the walls of hollow internal structures such as blood vessels, airways to the lungs, the stomach, intestines, and urinary bladder
69
Most neurons consist of 3 basic parts
1) Cell body : contains nucleus and other organelles 2) Dendrites: major receiving or input portion of a neuron 3) Axon: output portion of a neuron, conducting action potentials toward another neuron
70
tight junctions (sealing & barrier)
- Seals gaps between cells, preventing leakage. - Found in: Stomach, intestines, urinary bladder. - Prevents harmful substances from passing between cells into the blood
71
Adherens Junctions (strength & flexibility)
- Helps hold cells together with "adhesion belts". - Provides flexibility and resistance to separation. - Found in: Intestinal lining, epithelial cells
72
Desmosomes (adds strength)
- What it does: Works like “spot welds” to keep cells strong. - Where it's found: Skin, heart muscles
73
Hemidesmosomes (anchors cells)
- What it does: Attaches cells to a base layer (not to each other). - Where it's found: Skin, basement membranes.
74
Gap Junctions (cell communication)
- What it does: Creates small tunnels to share signals and nutrients. - Where it's found: Heart, nerves, bones