Chapter 3 Flashcards
Name the leukocyte-endothelial adhesion molecules responsible for leukocyte capturing & rolling.
Selectins (P, E, L)
PSGL1
VLA-4
In arresting the leukocyte in endothelium, what are the ligands for each of the following molecules?
LFA-1
VLA-4
a4b7-integrin
ICAM-1
VCAM-1
MadCAM-1
Which integrin & molecule are responsible for leukocyte intravascular crawling?
Mac-1 & ICAM-1
Sialomucin ligands on HEVs that bind to L-selectin on naive lymphocytes are called?
Peripheral node addressin (PNAd)
Which integrin ligand does aEb1 bind to?
E-cadherin
Which chemokine receptors act as coreceptors for HIV?
CCR5
CXCR4
Which chemokine ligand recruits lymphocyte to intestine?
CCL25
Which chemokine ligand recruits T cell to skin?
CCL27
Which chemokine ligand promotes B cell migration to lymph node & plasma migration to bone marrow?
CXCL12
Which chemokine promotes B cell & T follicular helper cell migration into follicles?
CXCL13
Which chemokine is required for DC migration from infection site to draining lymph node?
CCR7
Which gene & structure are mutated in LAD-1?
AR inherited CD18 gene mutation encodes beta subunit of LFA-1 & Mac-1 for migration
Which structure is lacked in LAD-2?
Golgi GDP-fructose transporter for carbohydrate ligands expression on E-selectin & P-selectin for adherence
Early recruitment of neutrophil is induced by () of macrophages.
() is the major chemokine in supporting neutrophil migration into tissue.
CXCL8
IL-8
What is the most important chemokine produced by resident tissues for classical monocytes migration?
CCL2 (MCP-1)
Name the
1) exit pathway of T cells from lymph node into bloodstream
2) chemoattractant involved
3) GPCR receptor involved
4) immunosuppressant that binds to (3)
1) S1P pathway
2) sphingosine 1-phosphate (S1P)
3) sphingosine 1-phosphate receptor 1 (S1PR1)
4) Fingolimod (FTY720)
Mesenteric lymph node & Peyer’s patches express () on HEVs for T cell recirculation.
MadCAM-1
Name the chemokine/integrin for T cell migration to
1) lymph node
2) skin
3) mucosa
1) L-selectin, CCR7
2) a4b1, CLA, CCR4
3) a4b7, CCR5
When B cells mature further, they express () which promotes movement into white pulp in response to ().
CXCR5
CXCL13
Homing of naive B cells depends on 3 chemokine receptors & their respective 4 ligands on HEVs.
CCR7 - CCL19/CCL21
CXCR4 - CXCL12
CXCR5 - CXCL13
Homing of naive B cell into Peyer’s patches involves () & () which bind to ().
a4b7 & CXCR5
MadCAM-1
Bone marrow-homing IgG-secreting plasmablasts express () & () which bind to () & () expressed on bone marrow sinusoidal endothelial cells.
VLA-4 & CXCR4
VCAM-1 & CXCL12
Mucosa-homing IgA-secreting plasma cells express () & () which bind to () & () on mucosal endothelial cells.
a4b7 & CCR9
MadCAM-1 & CCL25
IgG-secreting B cells express () & () which bind to (), () & () on endothelial surfaces at chronic inflammation sites.
VLA-4 & CXCR3
VCAM-1, CXCL9 & CXCL10
