Chapter 3

Question 1

Name the leukocyte-endothelial adhesion molecules responsible for leukocyte capturing & rolling.

Answer 1

Selectins (P, E, L)
PSGL1
VLA-4

Question 2

In arresting the leukocyte in endothelium, what are the ligands for each of the following molecules?

LFA-1
VLA-4
a4b7-integrin

Answer 2

ICAM-1
VCAM-1
MadCAM-1

Question 3

Which integrin & molecule are responsible for leukocyte intravascular crawling?

Answer 3

Mac-1 & ICAM-1

Question 4

Sialomucin ligands on HEVs that bind to L-selectin on naive lymphocytes are called?

Answer 4

Peripheral node addressin (PNAd)

Question 5

Which integrin ligand does aEb1 bind to?

Answer 5

E-cadherin

Question 6

Which chemokine receptors act as coreceptors for HIV?

Answer 6

CCR5

CXCR4

Question 7

Which chemokine ligand recruits lymphocyte to intestine?

Answer 7

CCL25

Question 8

Which chemokine ligand recruits T cell to skin?

Answer 8

CCL27

Question 9

Which chemokine ligand promotes B cell migration to lymph node & plasma migration to bone marrow?

Answer 9

CXCL12

Question 10

Which chemokine promotes B cell & T follicular helper cell migration into follicles?

Answer 10

CXCL13

Question 11

Which chemokine is required for DC migration from infection site to draining lymph node?

Answer 11

CCR7

Question 12

Which gene & structure are mutated in LAD-1?

Answer 12

AR inherited CD18 gene mutation encodes beta subunit of LFA-1 & Mac-1 for migration

Question 13

Which structure is lacked in LAD-2?

Answer 13

Golgi GDP-fructose transporter for carbohydrate ligands expression on E-selectin & P-selectin for adherence

Question 14

Early recruitment of neutrophil is induced by () of macrophages.
() is the major chemokine in supporting neutrophil migration into tissue.

Answer 14

CXCL8

IL-8

Question 15

What is the most important chemokine produced by resident tissues for classical monocytes migration?

Answer 15

CCL2 (MCP-1)

Question 16

Name the

1) exit pathway of T cells from lymph node into bloodstream
2) chemoattractant involved
3) GPCR receptor involved
4) immunosuppressant that binds to (3)

Answer 16

1) S1P pathway
2) sphingosine 1-phosphate (S1P)
3) sphingosine 1-phosphate receptor 1 (S1PR1)
4) Fingolimod (FTY720)

Question 17

Mesenteric lymph node & Peyer’s patches express () on HEVs for T cell recirculation.

Answer 17

MadCAM-1

Question 18

Name the chemokine/integrin for T cell migration to

1) lymph node
2) skin
3) mucosa

Answer 18

1) L-selectin, CCR7
2) a4b1, CLA, CCR4
3) a4b7, CCR5

Question 19

When B cells mature further, they express () which promotes movement into white pulp in response to ().

Answer 19

CXCR5

CXCL13

Question 20

Homing of naive B cells depends on 3 chemokine receptors & their respective 4 ligands on HEVs.

Answer 20

CCR7 - CCL19/CCL21
CXCR4 - CXCL12
CXCR5 - CXCL13

Question 21

Homing of naive B cell into Peyer’s patches involves () & () which bind to ().

Answer 21

a4b7 & CXCR5

MadCAM-1

Question 22

Bone marrow-homing IgG-secreting plasmablasts express () & () which bind to () & () expressed on bone marrow sinusoidal endothelial cells.

Answer 22

VLA-4 & CXCR4

VCAM-1 & CXCL12

Question 23

Mucosa-homing IgA-secreting plasma cells express () & () which bind to () & () on mucosal endothelial cells.

Answer 23

a4b7 & CCR9

MadCAM-1 & CCL25

Question 24

IgG-secreting B cells express () & () which bind to (), () & () on endothelial surfaces at chronic inflammation sites.

Answer 24

VLA-4 & CXCR3

VCAM-1, CXCL9 & CXCL10