Chapter 3 Flashcards
ATP Hydrolysis
Breakdown of ATP
Terminal phosphate bond breaks and releases energy
Leaves ADP, inorganic phosphate and H ion
ADP Hydrolysis
Breaks remaining terminal phosphate bond and releases energy, leaving AMP, H and P
Phosphagen Sytem
Uses creatine kinase to maintain concentration of ATP from CP and ADP
Law of Mass action regulates by amount of products and reactants available
How many ATP does glycolysis consume?
2 with blood glucose, 4 using transport system
Glycolysis
Breakdown of carbs (muscle glycogen or blood glucose) to resynthesize ATP
Results in Pyruvate, which can convert to lactate (Cori Cycle) in sarcoplasm or taken to mitochondria
Glycolysis and Krebs Cycle
Pyruvate converts into acetyl-CoA in mitochondria, then enters Krebs
NADH molecules enter electron transport system to synthesize ATP Again
Glycolysis Krebs Cycle Equation
Glucose + 2Pi + 2ADP + 2NAD+ → 2Pyruvate + 2ATP + 2NADH + 2H2O
Glycolysis Lactate Equation
Glucose + 2Pi + 2ADP → 2Lactate + 2ATP + H2O
Control of Glycolysis
Stimulated with high concentration of ADP, P, Ammonia, decreased pH and AMP: signs of increased ATP Hydrolysis and need for energy.
Inhibited: low pH, CP, Citrate, ATP and free fatty acids
Glucose and Glycogen Oxidation
Begins with glycolysis and ends in Krebs cycle
Fat Oxidation
Triglycerides are broken down by lipases that are hormone sensitive. This releases the free fatty acids into the bloodstream. They now circulate and enter the muscle fibers.
The free fatty acids enter the mitochondria of the muscle cells. They are then broken down to form acetyl-CoA and hydrogen protons.
Protein Oxidation
Protein is broken down to amino acids and then made into glucose, pyruvate and other things needed for the Krebs Cycle in order to end up as ATP.
Energy Production and Capacity
The max rate of ATP production and the total ATP able to be produced has an inverse relationship.
Phosphagen Depletion and Repletion
5-30 secs = 50-70% decrease
Complete ATP resynthesis takes 3-5 mins, Creatine takes 8
Glycogen Depletion and Repletion
Muscle is used more in high intensity, Liver in low. (60%)
BGL remains stable until over 50% intensity
Up to 24 hours, consuming carbs, to replenish