Chapter 24

Question 1

What nutritional condition is associated with muscle disease?

Answer 1

Vitamin E deficiency

Question 2

What forms of CK are their?

Answer 2

2 subunits
M - muscle
B - brain
CK1 (BB) - CNS
CK2 (MB) - cardiac
CK3 (MM) - skeletal

Question 3

CK half life

Answer 3

2-4 hours

Question 4

Non-pathological causes CK elevation

Answer 4

Spurious - haemolysis
Age - higher in puppies (normal by 7 months)
Surgery
IM injection
Recumbency

Question 5

AST half life?

Answer 5

12 hours

Question 6

How can haemoglobinuria and myoglobinuria be differentiated?

Answer 6

With myoglobinuria, plasma is usually clear
By adding ammonium sulphate - precipitates haemoglobin and leaves myoglobin in solution

Question 7

What infectious diseases are associated with myositis?

Answer 7

Neospora
Toxo
Leish
Sarcocystis
Trypanosoma cruzi

Question 8

What are the causes of lactic acidaemia?

Answer 8

Secondary to extreme muscle activity, sepsis, hypovolaemia
Primary enzyme defect - pyruvate dehydrogenase phosphatase 1 deficiency, pyruvate decarboxylase, enzymes of respiratory chain of Kreb’s cycle