Chapter 20

Question 1

Where is BNP released? What stimulates its release?

Answer 1

Cardiac myocytes
Stretch

Question 2

What factors other than cardiac disease can cause elevated NT-proBNP?

Answer 2

Reduced renal function
Systemic hypertension (cats)
Pulmonary hypertension (dogs)

Question 3

What cut offs can be used for NT-proBNP for establishing cardiac vs non-cardiac causes of dyspnoea in dogs?

Answer 3

> 1800 - cardiac likely
<900 - cardiac unlikely

Question 4

What are the strengths/weaknesses of NT-proBNP for detection of cardiomyopathy in cats?

Answer 4

100% specific but 70% sensitivity for detecting occult cardiomyopathy
Not found useful in mildly affected cats

Question 5

How can NT-proBNP be used to detect canine cardiomyopathy?

Answer 5

proBNP >457 + Holter identified dogs with subclinical DCM

Question 6

What cut offs can be used for NT-proBNP for establishing cardiac vs non-cardiac causes of dyspnoea in cats?

Answer 6

> 270 - cardiac likely
<100 - cardiac unlikely

Question 7

Where are troponins found? What are they markers of?

Answer 7

Intracellular
Cardiac injury

Question 8

What non-cardiac factors can cause elevation in troponin?

Answer 8

Cardiac injury secondary to non-cardiac disease (renal disease, pyometra, GDV)
Age
PHT (possibly)

Question 9

Is troponin useful for differentiating cardiac vs non cardiac dyspnoea?

Answer 9

No

Question 10

What are the possible causes of myocarditis?

Answer 10

Trauma
Chemical - doxorubicin
Infectious - Parvo, toxo, neospora, borrelia, trypanosoma cruzi, Leish

Question 11

Which breeds have myosin binding protein C mutation been identified in? What condition does it cause?

Answer 11

Maine Coon and Ragdoll
HCM