Chapter 20 Pathology Flashcards
Allodynia
Pain sensitization (increased responsiveness) following normally non-painful and often repetitive stimulation.
Ankyloglossia
Tongue tie, and then usually short, text, or type band of tissue the tethers the bottom of the tongue to the floor of the mouth and restricts the tongues range of motion
Areola
The pigmented portion of the breast surrounding the nipple
Axilla
Armpit
Cooper’s ligaments
Fibrous bands that fix the breast to underline pectoral fascia
Eczema
Skin condition characterized by itching, typically occurs in response to a topical irritant
Erythema
Abnormal redness in the skin
Exudate
Fluid that extrude or seeps out of injured tissue
Fissure
A division, split, or grove in tissue (in Lactation, the term specifically refers to the nipple)
Fluctuant
Subject to change, variable, movable, compressible
Inferior pedicle technique
Breast reduction surgery in which some portion of the breast remains intact
Mastitis
Inflammation of the breast
Montgomery glands
Sebaceous glands within the areola, surrounding the nipple
Nipple bleb
A small white spot on the tip of the nipple that looks like a tiny milk filled blister
Nipple translocation
Surgery in which the nipple is removed, the breast tissue is reduced, and the nipple is reattached
Plugged duct
Localized area of milk stasis, with distention of the breast tissue
Psoriasis
Skin condition with clearly demarcated plaques
Vesicle
A small fluid filled sac or blister
Breast evaluation
When there are concerns about milk production good to ask if there was a noticeable change in breast size during pregnancy and after birth.
It is normal for there to be minor differences in breast sides with the left breast often larger than the right.
The breast forms along the embryologic milk line which extends from the axilla to the groin.
Approximately 2 to 6% of women have accessory mammory tissue.
Polythelia refers to accessory nipple tissue and polymastia refers to accessory breast tissue.
The breast is fixed to the underlined pectoral fascia by Cooper‘s ligaments. Weakening of the bands may result in breast sagging. Sagging may occur because of breast changes during pregnancy and does not affect lactation.
There is great diversity in the size of the nipple and areola.
Inverted nipples result when the epithelial pit (during development) fails to revert. Nipples that appear flatten may not actually be inverted and can be observed and protruding when compression is applied behind the areola.
It is important to assess the nipple for any lesions which may suggest infection or trauma. Nipple fissuring is suggestive of sub optimal latch and should prompt further observation and assessment of infant feeding.
Macgomery glands
Ductile openings of lactiferous and sebaceous glands that appear on the areola. May become more prominent in Pregnancy and Lactation. Some secretion from these glands may occur this is normal. Rare circumstances glands may become obstructed and painful.
Prior breast surgery
Should pay attention to the location of scars. Those in the periareolar region are most concerning for potential insufficient milk production. Breast biopsy scars are typically small and can be either in the periareolar region or elsewhere. Breast biopsies for benign disease can usually breast-feed fine.
Breast augmentation can be performed using a variety of incisions. Implants can be placed via laparoscopic tunneling from the Periumbilical region so there are no visible breast scars. More commonly breast implants are placed from incisions in the axilla or inframmatory fold (under the breast) or periarolar incisions are use. Inquire about breast augmentation because there may be implants because of developmental failure if there is no underlying breast tissue. Most are for aesthetic reasons. Silicone implants are not a contraindication to breast-feeding.
Breast reduction surgery can be performed with a number of different techniques. One technique includes nipple translocation and then the nipple is reattached in this procedure there is circumferential periareolar incision. All ducts and nerves to the nipple are severed. With this procedure milk may still exit the nipples personally due to re-canalization.
Another method is to use the inferior pedicle technique. This can be identified by surgical scars around the edges of the areola and additional scar line extending downward from the inferior areola to the mid breast. Breast reduction is routinely associated with decreased milk production although it may still be possible.
Observation of breast and all four categories should be done too
Divide the breast in four quadrants. Document findings according to observations noted in the upper outer upper inner lower outer and lower inner. Note any significant breast asymmetry, wide spacing of nipples or breast tissue, nipples or areola that appear disproportionately large in relation to the breast, visible scars, piercings, or skin retraction.
Some parents may not mention prior breast surgery because they are not aware of its potential.
Observing the breasts can be very important in assessing infection. Mastitis typically results in breast erythema and cellulitis over laying the affected portion of the breast. Early mastitis may have a subtle color change so useful to gently touch and release skin. The red color the blanches upon release suggest erythema.
Warmth of the overlying skin can be useful in assessing for infection.
Palpitation
Palpating the breast will says for any masses that could result in a plug duct or an abscess. Useful to document the size, location, and mobility of the mass in addition to noting if any of the masses are tender.
Nipple pain
A common reason many women end breast-feeding earlier than intended.
There are many causes of nipple pain: during early breast-feeding some degree of breast as comfort is common, 73% of breast-feeding mothers experience pain on the first day of breast-feeding. Unclear why so many experience pain but it is likely that hormones and trauma related to learning correct latch and positioning are contributors.
Trauma to the nipples worsen pain and predisposed to paired to other complications. If persist pass the first few weeks of breast-feeding it deserves further evaluation. Optimizing latch and positioning remains the mainstay of nipple pain management. If parents are pumping or manually expressing milk it is important to assess their technique.
There is not sufficient evidence to support a particular treatment for nipple pain.
A careful history should be done: when did the pain begin and the nature in details of the pain. History of medical and pregnancy complications. History of prior breast-feeding experiences. History about the infant. Assessment should include: examination of the breast. Examination of the infants oral anatomy and a suck assessment.
An observation of a breast-feeding session or pumping.
Other causes of pain include nipple damage and trauma, dermatologic conditions, infections, vasa spasm, pain syndrome’s and breast drainage tissues such as plug ducts and over supply.
Nipple trauma or fissuring
This is most likely due to poor latch or positioning. If the fissures are persistent or have yellow crusting a superficial bacterial infection should be suspected. An infection can be treated with a topical mpirocin and or bacitracim ointment and may be bloated off prior to the next feeding and are compatible with breast-feeding - recommendation of topical medication must come from a healthcare provider.
Ankyloglossia
Inspect the infants mouth for a tongue tie or short lingual frenulum (lip tie). Consider referring infant to a trained professional for a frenulotomy.
Nipple trauma and pain may result from pumping or manual expression
Should be assessed to assure the pump flanges fit correctly. Pain can result from pumping at inappropriate intervals or the suction set too high. Sometimes parents may massage the breasts or manual expressed milk in an overly vigorous way.
Dermatological conditions may cause discomfort
Eczema (atopic dermatitis) characterized by itching and may vary in appearance. May have vesicles with exudate and crusting, whereas chronic lesions are typically dry and scaly. Skin thickening may occur due to persistent scratching. Usually occurs in response to an irritant that is often topical.
Psoriasis appears as clearly demarcated plaques that may have overlying scale. Often a history of psoriasis elsewhere on the body. Parents should be referred to a healthcare provider who may prescribe a topical steroid. Usually are compatible with breast-feeding but any excess should be blotted off the nipple. May also prescribe a nonsedating antihistamine such as loratadine or certirizine that may be beneficial for itching and are compatible with breast-feeding.
Herpes Simplex virus (HSV)
HSV typically percents as a cluster of small vessicles that later burst and leave ulcers. Lesions are extremely painful. HSV-1 is most commonly responsible for oral lesions, and HSV-2 typically causes genital lesions.
HSV can cause lesions on the breast.
Oral and general lesions do not preclude breast-feeding but they do require meticulous hygiene and good handwashing to avoid spreading the virus to the infant.
HSV lesions on the breast require a temporary cessation of breast-feeding on the affected breast due to the risk of spreading.
Milk from the affected breast should not be given to the infant.
It is important to prevent contact because a life-threatening infection can occur.
Oral medication‘s for HSV such as ancyclovir or valacyclovir are prescribed to treat and prevent infection they are usually compatible with breast-feeding.
Herpes zoster
Caused by reactivation of the varicella zoster virus (VzV) which causes chickenpox. Initial infection with the VZV causes chickenpox which typically produces vesicles that are very pruritic or itchy. Mothers with acute chickenpox at the time of birth should be separated from infants because the infection is spread by respiratory contact or contact with lesions. Any lesions involving the breast could contaminate milk
VZV vaccination is available for infants older than one year of age. Vaccination after exposure is typically effective in preventing disease due to long incubation period. Reactivation of the VZV results in shingles or herpes zoster. Localized skin infection characterized by painful circular rash that occurs in a linear pattern along dermatomes. Form crust in 7-10 days and it’s no longer contagious.
If shingles outbreak is remote from the breast, covering the lesions, practicing good hygiene and diligent handwashing should prevent transmission and breast feeding can continue.
If involves the breast, nipple, or areola breast-feeding must be temporary avoided on the affected breast milk from that breast should be discarded.
Vasospasm is another potential cause of nipple pain
Vasospasm typically result in shooting, burning, or spasming pain associated with blanching and color change of the nipple. Onset of symptoms may be sudden. Nipple appears pale due to limited blood flow. Followed by a bluish discoloration due to lack of oxygen appears to turn to a red color with reperfusion. Cold exposure may trigger the symptoms.
Parents may have a history of Raynaud phenomenon where they may note similar symptoms in their fingers or toes with cold exposure.
Visualizing the nipple color changes associated with pain is typically diagnostic. Initial treatment includes keeping breast warm, apply warm compresses immediately after breast-feeding and avoiding cold.
The medication such as nifedipine may be prescribed for more severe cases.
Allodynia is a condition in which pain sensitization (increase responsiveness), follows normally non-painful and often repetitive stimulation. Even light touch is perceived as pain
Parents may note sensitivity to their bra or clothing. Useful to explore any history may have of chronic pain disorders, fibromyalgia or other painful condition. Over-the-counter pain medication such as ibuprofen may be helpful in managing symptoms. May need further evaluation. Plug ducks, engorgement, and oversupply may result in breast and nipple pain. Pay may be due to breast distention and inflammation associated with these conditions. Overproduction of milk and an over active milk ejection reflex may cause the infant to pinch the nipple to reduce flow causing pain and trauma.
Engorgement may interfere with the infants ability to latch and transfer milk
Engorgement is caused by increase vascular flow, tissue edema, and the onset of copious milk production that may exceed the infants ability to extract. Compression of the blood vessels and milk ducts can worsen the encouragement. Not uncommon for parent to experience a low-grade fever but fevers of 101 or higher should be investigated for infection.
Primary encouragement occurs with the onset of lactogenesis I I. This is typically 3 to 5 days after delivery although it may be delayed for additional 1 to 2 days due to cesarean delivery.
Approximately 36% of mothers experience engorgement.
Most effective management is proactive avoidance. Have a person who is knowledgeable about breast-feeding evaluate the feeding frequency, latch, and milk transfer early during lactation.
Secondary encouragement occurs later doing established lactation. Possible causes include the following; excessive pumping, intentional or unintentional change in feeding intervals, infant illness that affects infants ability to remove milk, latch difficulties.
Can lead to problems with latch difficulties infants have in attaching to an engorged breast. May lead to a cycle of worsening engorement due to poor milk removal. Treatment for engorgement includes adequate milk removal.
Massage the breaths prior to feeding or pumping may be helpful.
Reverse pressure softening of the nipple can be useful in resolving edema to improve latch.
Nonsteroidal anti-inflammatory drugs are important to minimize pain from engorgement because pain can interfere with milk let down.
Important for the parent to alternate feeding positions and to feed, pump or manual express frequently to keep the breast well drained. Some parents find a warm shower pride of feeding help soften the breast.
Plugged ducs can be painful and lead to a breast infection
A plugged duct is a localized area of milk stasis with distention of the involved mammary tissue. Parent often notes palpable lump or knot in the breast which sometimes may decrease in size with milk removal. Predisposing factors are similar to those for encouragement. May occur after missed feedings, prolongation of feeding intervals or poor infant latch. Parents with very abundant milk production may be at risk. Also pressure against a portion of the breast by a poorly fitted or overly restrictive bra can be a risk factor.
Treatment for plug ducts include frequent breast-feeding. Moist heat prior to feeding and gentle massage affected area during feedings may be helpful.
Alternating a feeding position to place the infants chin or nose in line with a plugged area may optimize milk extraction.
Lecithin 1200 mg three times daily has been suggested for recurrent plug ducts.
Hand expression between the areola and the plug duct can be effective.
If it does not resolved in approximately 72 hours refer to healthcare provider.
Nipple blebs, or milk blebs sometimes occur in association with plug ducts so an inquiry should be made regarding both.
A milk or nipple bleb appears as a small white spot on the tip of the nipple. A blister on the nipple can sometimes be mistaken for a milk blend. Data for the effectiveness of treatment options is limited. Initial therapy should be to optimize latch and positioning so good breast drainage. A parent incidentally noticed the bleb and is not in pain then you can ignore it. There is some evidence that topical steroids directly on the bleb may be beneficial. A referral to an experienced professional for unroofing, or opening, persistent blebs maybe considered if the parent continues to be in pain. Parents should be discouraged from doing this themselves.
Candida infection are relatively common and can affect breast-feeding for both parrot an infant
There is controversy regarding the diagnosis of candida infections of the breast. In immunocompetent people a superficial Canada infection may involve skin in other areas of the body such as the mucous membranes of the vagina or in the vulva and under the breast.
Candida albicans causes most clinical sections.
If the breast or nipple remains moist and warm a superficial candida infection of the breast can occur.
The infection is typically red and may have satellite lesions on the periphery of the redness. Infants may have a similar appearing diaper rash.
Canadida is a normal organism that can be culture from normal healthy tissue from skin, mucous membranes in the G.I. tract.
The superficial infection occurs with candida becomes overgrown and causes symptoms such as itching and burning.
Invasive candidal infections are rare in immunocompetent adults.
Newborn infants can get oral thrush or a candida infection of the oral mucous membranes. Characterized by white plaques on the inner cheeks palate or tongue. White plaques that are persistent and cannot be wiped off are indicative of thrush. Milk can be wiped out.
The infants mouth can be treated with a nystatin suspension or miconazole gel. Oral topical medication‘s require a prescription for the infants healthcare provider.
Treatment of the infant does not mandate treatment of the asymptomatic parent.
Risk factors include ia warm moist environment so objects to keep the breast unusually warm and moist can predisposed to infection. These can include breast-feeding pads with plastic backing.
Antibiotics increase the risk of candida infections.
Diabetes is a significant risk risk factor.
Also the use of steroids, immuno suppressant medication‘s, an immune deficiency diseases.
A superficial candida infection can be treated with a dilute solution of Gentian violet (less than 0.5% aqueous solution) for not more than seven days. Longer duration and higher doses have been associated with ulcerations.
Also topical antifungal ointment or cream can be applied. This medication‘s are poorly absorbed orally. Excessive amount should be blotted off the breast prior to feeding.
Oral fluconazole can be prescribed if the parent has difficulty complying with topical therapy.
Fluconazole should not be used with domperidone, or other medication‘s to prolong the cardiac QT interval as a potential side effect.
Association of candida with nipple and breast pain and a normal appearing nipple remains controversial. Some authors have suggested that candida may be responsible for deep, shooting pain in the breast. With nipple trauma or fissuring is present research suggested a bacterial infection is more likely and may benefit from topical antibiotics.
Mastitis is an inflammatory condition of the breast
The affected portion of the breast becomes painful, red, and swollen. Fever is common with mastitis and other flu like symptoms such as muscle aches, headache, fatigue, and nausea. Frequency of mastitis varies across studies from 9 to 20%.
Predisposing factors for mastitis include nipple damage, overproduction, plug duct, encouragement and use of a nipple shield. Appears to be more common in first time parents.
Treatment of early mastitis includes rest, fluid, and frequent thorough breast drainage. Must try to identify why the mastitis occurred and correct any predisposing factors.
If nipple trauma is present attention should be given to a optimizing latch. If engorgement is present focus should be on draining the breast and avoiding abrupt changes in breast-feeding frequency.
If symptoms worsen or unresolved after 12 to 24 hours of conservative measures consideration should be given to starting antibiotics.
Patients with more severe symptoms or high fever should start antibiotics promptly.. Ibuprofen can be used to treat mastitis pain. Pain can inhibit the letdown reflex and limit breast damage drainage which can worsen mastitis.
During mastitis milk is not harmful to a full-term healthy infant.
Weaning during mastitis can increase risk for developing a breast abscess.
Most common organisms that cause mastitis include staphylococcus aureus and streptococcus species and escheerichia coli.
First line antibiotics include a penicillin resistant penicillin such as the cloxacillin. First generation cephalosporin antibiotics are also a good choice.
Parents with severe penicillin allergy clindamycin can be used.
Possible reasons for hospital admission to the mastitis include: parent is extremely ill, an infection is not responding to oral antibiotics, an unclear source of the infection, parent was too ill to tolerate oral medication‘s, cases where there is a high suspicion for a breast abscess.
Milk culture should be considered for mastitis if conditions does not respond to antibiotics.
Prior to a culture, the nipple and areola must be cleansed before collecting milk. A small amount of milk is expressed and discarded. Milk need to be manual Xpress into a sterile collection cup or using a sterilize pump parts. The millk culture is not anticipated to be sterile. Purpose of culture is to assure that the resistant organism is not found.
Use of probiotics may be helpful in managing early mastitis. Recurrent mastitis requires investigation into the cause of occurrence: questions to consider include was the initial episode in completely treated, did the symptoms resolved and did the parent stop the therapy early, what is the initial anabiotic choice in adequate, did the infection result of the underlined predisposing factor persistent, does the parent continue to have an hour production of milk. Important to know if the recurrence is in the same breast in the same portion of the breast if in the same place a structural problem localized to that aspect of the breast, if recurrence is in a different location suggests a milk production or drainage issue.
If a parent is pumping it is important to evaluate the pump as a potential site of contamination: is pump been clean properly, parts maintained, what hygiene and cleaning practice parent using.
For recurrent infections a midstream milk culture should be preferred. They also need to have a more prolong course of 2 to 3 weeks of antibiotics. Importance to stress compliance with medication and to minimize any predisposing factors.
Breast abscess is a localized collection of pus in the breast tissue
Symptoms are similar to mastitis with the additional findings of a fluctuant mass in the breast.
Symptoms can be localized to the abscess in the breast if the infection is well encapsulated. Diagnosis is usually made by physical exam although ultrasound may be useful. Approximately 3% of women with mastitis develop a breast abscess. Predisposing factors include those that increase the risk of mastitis. Also delayed or inadequate treatment of mastitis increases likelihood of a breast abscess. Often caused by S. Aureus.
Initial management includes serial ultrasound guided aspirations and using antibiotics. Incision and drainage in addition to antibiotics may be required for abscesses larger than 10 cm for those that lack management with serial aspirations. Incision and drainage are likely to be associated with hospitalization, longer healing time, use of packing, pain, worse cosmetic result, and disruption of breast-feeding. Using smaller incisions and drains limit these disadvantages.
Milk fistula formation may be a rare complication of incision and drainage. In this situation, milk continues to drain through the surgical incision during lactation. This can be managed by occluding the incision site with something that can collect the leaked milk.
Pain management should be employed. Parents who require incision and drainage can use anti-inflammatory drugs but also may need narcotics.
During treatment, feeding from the unaffected breast can continue. Feeding from the effected breast depends on the clinical situation, method of transit, breast anatomy, and location of the abscess.
Breast masses
Although breast masses may be related to lactation (such as a plugged milk duck, lactating adenoma, or breast abscess) other masses can occur during lactation. Breast cancer is rare in breast-feeding women. If a persistent breast mass is noted in a lactating parent it can be safely evaluated while breast-feeding continues. Ultrasound is the preferred initial imaging technique. Ultrasound can determine if the mass is cystic or solid. Solid masses can be evaluated with a biopsy without weaninng. Mammography does not adversely affect milk. Parents should pump or breast-feed prior to mammogram so breast as well drained. A normal mammogram result is not a sufficient evaluation for a breast mass, a breast ultrasound should be performed. An MRI can be performed on breast-feeding parents but the radiologist should know that they are breast-feeding so an accurate interpretation can be performed. Breastfeedin can continue even if an excisional biopsy of a mass is required.
Hyperbilirubiemia
Elevated level of bilirubin in a neonatal’s blood. A sign of elevated bilirubin levels is jaundice or yellowing of the skin and whites of the neonate eyes
Hypoglycemia
A whole blood glucose value that is less than 45 mg/dL
Infants with perinatal stress
Infants with a five minute Apgar score or less than five. The score lets the healthcare team know how well the baby is doing outside the world.
Kernicterus
A disorder due to severe jaundice in the newborn. Deposition of the pigment bilirubin in the brain, which causes damage to the brain, potentially leading to sensory neural hearing loss, upward gaze palsy, dental enamel dysplasia, cerebral palsy, and cognitive impairment. Also called bilirubin encephalopathy
Large for gestational age (LGA)
An infant with a birthweight that is greater than the 90th percentile for gestational age
Low birthweight
Infants born weighing less than 2500 g (5 pounds, 8 ounces)
Pathologic jaundice
The condition that occurs within 24 hours after birth, with a rapidly rising total serum bilirubin concentration (increase of more than 5 mg/DL per day) and a total serum bilirubin level higher than 17 mg/DL in a full-term newborn.
Phototherapy
A treatment for reducing high bilirubin levels in which the infants dermal and subcutaneous bilirubin absorb light waves which convert the bilirubin into a more easily excreted form. In the standard form of phototherapy the baby lies in a bassinet or a close plastic crib (incubator) and is exposed to a type of fluorescent light that is absorbed by the babies skin, also called ultraviolet light therapy.
Physiologic jaundice
A condition caused by the breakdown of red blood cells (which release bilirubin into the blood) and the immaturity of the newborns liver (which cannot effectively metabolize bilirubin and prepared for excretion into the stool and urine).
Preterm
An infant born earlier than 37 completed weeks of gestation
Small for gestational age (SGA)
An infant with a Birth way that is less than the 10th percentile for gestational age
Transcutaneous Bilirubin (TCB)
Screening tool used to assess bilirubin levels in infants
Normal glucose regulation in the newborn
Glycogen reserves that are available for conversion to glucose during the immediate neonatal period or lai down during the latter part of the third trimester
glucose is the primary nutrient for brain metabolism and the placental supplement terminates at birth
newborns have a greater demand for glucose than children and adults because of their large brain to body weight.
Preterm infants have even greater demand for glucose and have limiteded absolute glycogen reserves depending on their gestational age.
Neonatal physiology is a factor in glucose levels. At birth there is a transition. As glucose homeostasis is established by the infant. The net affect is mobilization of glycogen and fatty acids. The collective activities that maintain glucose homeostasis are called counter regulation and they consist of: glycogenolysis which is the mobilization and release of glycogen from body stores to form glucose and gluconeogenesis which is the production of glucose by the liver and kidneys from non-carbohydrate substrates such as fatty acids and amino acids.
After 12 hours the baby is dependent on glucose made from dietary intake of milk components and glucose neogenesis to maintain blood glucose as well as free fatty acids.
Human milk is more ketogenic than formula enabling a breast-fed baby to create high levels of alternative fuels until the milk production increases sufficiently to draw on milk components for glucose synthesis.
High levels of Ketone bodies enable breast-fed babies to demonstrate lower measured blood glucose levels but still maintain the optimal production of brain fuels.
Glycogen stores are converted to glucose rapidly depleting glycogen stores over the first hours of life.
Fat metabolism provides glucose substrate beginning at 2 to 3 days of age.
Risk factors in clinical signs for hypoglycemia
Routine screening and monitoring of blood glucose concentrations is not indicated in healthy term newborns after a normal pregnancy and delivery.
Common symptoms of neonatal hypoglycemia include: jitteriness, tremors, feeding intolerance, seizures, apnea, bradycardia, hypotonia, listlessness, or limpness, hypothermia, respiratory distress, including grunting and tachypnea or apnea, high pitch cry, irritability, cyanosis.
Infants who may be at risk include: small for gestational age, large for gestational age, low birth weight, born to mothers who have pre-gestational or gestational diabetes, preterm infants, infants with perinatal stress, discordant twin (smaller twins weight is 10% less than larger twin), infants experiencing cold stress, infants exposed to mediations during labor that are known to cause decrease blood sugar(oral hypoglycemics, terbutaline, or propranolpl), infants with clinical evidence of wasting of fat or muscle bulk, an infant that is not feeling well.