Chapter 20: Amines Flashcards
Where can amides be protonated?
The oxygen or nitrogen
Why is SN2 of an alkyl halide + ammonium not preferred for amine synthesis?
It forms additional di- and try-alkylamine products
What is a good way to make an amine from alkyl halide?
SN2 with azide ion (N3-) and then reduction (LiAlH4 or H2/Pd)
What can be used to prepare an amine from a nitro compound?
2 alternatives
H2/Pd, heat
or
Metal + acid (Fe, HCl)
What can be used to form an imine from aldehyde or ketone?
R-NH2 and H+
What reagent is used to reduce a nitrile to an amine?
LiAlH4
How is a diazonium ion formed?
An amine is treated with nitrite (NaNO2)
How can a diazonium ion be converted to a halogen?
A copper CuX compound (CuBr, CuCl, CuCN..)
What can amines react with to produce an amide?
An acyl chloride
