Chapter 2 Inflammation and repair Flashcards
What are the 5 subtypes of leukocytes?
Lymphocyte Monocyte-Macrophage Polymorphonuclear neutrophil (aka neutrophil) Eosinophil Basophil
Which type is the majority of leukocytes?
Neutrophils
This immunity is a quick, non-specific response
Innate immunity
Antibody generator
Antigen
What are the 5 signs of inflammation?
Rubor=redness Calor=heat Tumor=swelling Dulor=pain Loss of function
What are the 5 steps of inflammation?
Recognition of injury/agent Recruitment of leukocytes Removal of agent Regulation of response Resolution/repair
This type of inflammation has a rapid onset with neutrophil accumulation
Acute inflammation
This type of inflammation has insidious onset with lymphocyte and macrophage accumulation
Chronic inflammation
What is acute inflammation stimulated by?
Infection, trauma, necrosis, foreign material, and immune-mediated reactions
What are two major mechanisms of acute inflammation?
Vascular changes and cellular events
This recognizes pathogens and stimulates membrane proteins and inflammation
Toll like receptors
These recognize foreign invaders, are cytoplasmic, and function in dead cell recognition
Inflammasome
Describe the mechanism of vascular changes in inflammation
Immediate vasoconstriction Vasodilation Slows circulation Leukocytes collects along wall and induce margination Increased permeability
Describe the mechanism of permeability
Endothelial contraction Endothelial injury (necrosis) Leakage from neovasculature
Infection of the lymphatic channel
Lymphangitis