Chapter 2 Inflammation and repair Flashcards

1
Q

What are the 5 subtypes of leukocytes?

A
Lymphocyte
Monocyte-Macrophage
Polymorphonuclear neutrophil (aka neutrophil)
Eosinophil
Basophil
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2
Q

Which type is the majority of leukocytes?

A

Neutrophils

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3
Q

This immunity is a quick, non-specific response

A

Innate immunity

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4
Q

Antibody generator

A

Antigen

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5
Q

What are the 5 signs of inflammation?

A
Rubor=redness
Calor=heat
Tumor=swelling
Dulor=pain
Loss of function
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6
Q

What are the 5 steps of inflammation?

A
Recognition of injury/agent
Recruitment of leukocytes
Removal of agent
Regulation of response
Resolution/repair
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7
Q

This type of inflammation has a rapid onset with neutrophil accumulation

A

Acute inflammation

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8
Q

This type of inflammation has insidious onset with lymphocyte and macrophage accumulation

A

Chronic inflammation

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9
Q

What is acute inflammation stimulated by?

A

Infection, trauma, necrosis, foreign material, and immune-mediated reactions

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10
Q

What are two major mechanisms of acute inflammation?

A

Vascular changes and cellular events

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11
Q

This recognizes pathogens and stimulates membrane proteins and inflammation

A

Toll like receptors

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12
Q

These recognize foreign invaders, are cytoplasmic, and function in dead cell recognition

A

Inflammasome

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13
Q

Describe the mechanism of vascular changes in inflammation

A
Immediate vasoconstriction
Vasodilation
Slows circulation
Leukocytes collects along wall and induce margination
Increased permeability
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14
Q

Describe the mechanism of permeability

A
Endothelial contraction
Endothelial injury (necrosis)
Leakage from neovasculature
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15
Q

Infection of the lymphatic channel

A

Lymphangitis

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16
Q

Inflammation of a lymph node

A

Lymphadenitis

17
Q

Disease of the lymph nodes

A

Lymphadenopathy

18
Q

List the 4 steps for recruitment of leukocytes

A

Margination and rolling along vessel wall
Adhesion to endothelial cells
Transmigration between endothelial cells
Migration

19
Q

What predominates the inflammatory response during the first 24 hours

A

Neutrophils

20
Q

This removes dead tissue with attachment of opsonins and collections to the surface of the target

A

Phagocytosis

21
Q

This marks a cell for death

A

Opsonin

22
Q

This binds a microbe to a macrophage for phagocytosis

A

Collectin

23
Q

What are 3 outcomes of acute inflammation?

A

Resolution
Progression into chronicity
Scarring

24
Q

Characterized by excessive serum such as a burn blister or virus

A

Serous

25
Q

Severe injuries which result in scar formation

A

Fibrinous

26
Q

When inflammation is near an organ or tissue surface and a local defect is produced by the shedding of necrotic tissue

A

Ulcerative

27
Q

Contains pus

A

Purulent