Chapter 18 Flashcards
Osteoarthritis is:
the progressive deterioration and loss of cartilage and bone in one or more joints
Crepitus:
occurs when the cartilage disintegrates and pieces of bone and cartilage “float” in the diseased joint causing crepitus, a grating sound caused by loosened bone and cartilage
Cause of PRIMARY OA:
aging
genetic factors
Hips, knees & hands most commonly affected
Cause of SECONDARY OA:
Joint injury (excessive use, trauma or RA)
obesity
Typical onset of RA:
35-45 YR
Typical onset of OA:
Older than 60 yrs
Risk factors of RA
Autoimmune (genetic basis)
Emotional stress (triggers exacerbation)
Environmental factors
Risk factors of OA:
Aging
genetic factor (possible)
Obesity
Trauma
Occupation
Disease process for RA & OA
RA: Inflammatory
OA: Degenerative
Disease pattern for RA:
Bilateral, symmetric, multiple joints
Usually affects upper extremities first
Systemic
Disease pattern for OA:
May be unilateral, single joint
Affects weight bearing joints, hands, spine
Nonsystemic
Common drug therapy for RA:
NSAIDS (Short term use)
Methotrexate
Leflunomide (Arava)
Corticosteroids
Immunosuppresive agents
Common drug therapy for OA:
NSAIDS (Short term use)
Acetaminophen
Analgesics
clinical manifestations of OA
Joint pain and stiffness
Crepitus
Herberden’s nodes
Bouchard’s nodes
joint effusions
Atrophy of skeletal muscle
Early: clinical manifestations of RA (joint/systemic)
Joint stiffness/inflammation
Low grade fever
weakness
fatigue
anorexia
paresthesias
swelling