Chapter 16: Evolutionary Biology Flashcards

1
Q

antibiotic issue

A
  • antibiotics were being overprescribed causing bacterial resistance

How?

  • Within a large population of bacteria, there exists a small number of individual cells that are resistant due to a random mutation in DNA, these will grow and divide to carry the drug-resistant mutation in the population
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2
Q

evolution

A
  • gradual change of populations of organisms over time
  • changes in allele frequencies over time
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2
Q

how has the definition of evolution changed

A

old def: descent with modification

new: change in characteristics of populations over time

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3
Q

what does evolution help explain

A
  • underlying common features that organisms possess
  • huge diversity of life on earth
  • how species continue to change over time in response to environmental changes and challenges
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4
Q

natural selection

A
  • mechanism that can drive evolution
  • idea that organisms best suited to their environment have the greatest likelihood of survival and passing their traits to the next generation

AIM: yield fertile offspring

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5
Q

what did Darwin base his theory of natural selection on?

A

1) overreproduction
- all species tend to produce excessive numbers creating a struggle for existence

2) Individual variation
- variation exists amongst individuals in a population
- much of this variation is heritable

IDEA OF: “ survival of the fittest”
- overproduction and struggle for resources
- variation in traits (phenotype) amongst offspring that must be heritable otherwise its not N.S.

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6
Q

Differential Reproductive Success is linked to what mechanism of evolution

A

N.S.
- individuals with traits best suited for the local environmental leave more fertile offspring

i.e.
- pesticide resistance in insects
- development of antibiotic resistance
- drug-resistant strains of HIV

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7
Q

The essence of evolution (VIA N.S.)

A

1) all organisms vary genetically within a population [selection acts upon this variation]

2) genetically based traits are passed on from one generation to the next [traits must be heritable to be selected upon]

3) organisms w/ traits that are favourable to their survival (+reproduction) live and pass on their genes to the next gen.

4) evolution can happen in a few gen. but major changes [speciation] often takes long periods of time

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8
Q

“evolution can occur quickly’

A

True; major changes (speciation) takes time

  • however, you wouldn’t notice it within 1 gen. in your own body (aside from your microbiome)
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9
Q

fitness

A

FITNESS: an individuals reproductive success {a composite measure of survival and reproduction}

  • an organism has higher fitness than another if its leaves more surviving offspring
  • 3 aspects of fitness:
    1) fitness is RELATIVE (doesn’t;t matter how many offspring an individual leaves as long as its more than others in the population)
    2) trait is only adaptive if it INCREASES FITNESS
    3) traits that increase fitness may change (what’s fit now may not be in 2 generations due to changes in environment)
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10
Q

theories and hypotheses

A

hypothesis: idea that may/may not be true

theory: hypothesis that has been continuously tested and well-supported {NOT REFUTED}

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11
Q

social darwinism

A
  • pseudoscience that use the idea of “survival of the fittest” in non-scientific backgrounds and context
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12
Q

Evolution is a theory about the origin of life

A

Misconception!

  • evolution mainly deals with how life changed AFTER its origin
  • evolution focuses on how life “branched and diversified”
    (its not trying to explain the origin of life, its trying to explain how its changed over time)
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13
Q

Organisms are always getting better

A

Misconception!

  • natural selection weeds out individuals that are unfit in a particular byproducts
  • we aren’t byproducts or END GOAL of a species either

rather than a staircase analogy, think of it like a tree branch analogy, there is NO end goal to evolution

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14
Q

Evolution = Natural Selection

A

Misconception!

  • evolution is not the same as N.S.
  • N.S. is a mechanism (form of evolution, the same way genetic drift is)
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15
Q

T/F: the concept of evolution was around before Charles Darwin

A

T: Darwins idea was using N.S. (as a mechanism) to help explain patterns of evolution

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16
Q

Evolution means Life changed by chance

A

Misconception!

  • chance mutations are the ultimate source of genetic variation (but evolution by N.S. is NOT by chance, its selected for by the environment)
  • bullet in car analogy:
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17
Q

what is random and what is not random

A

RANDOM: source of change that needs to be selected upon (genetic variation through mutations)

NOT RANDOM: N.S., the process whereby some variants survive and others don’t

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18
Q

what is the bullet in car analogy

A

if you shot a bullet in an engine there’s a 99.9% chance it does something bad. However, it could plug an oil leak which is good.

  • neutral/good/bad mutations, and those good mutations can enhance fitness
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19
Q

Organisms try to adapt

A

Misconception!

  • N.S. leads to adaptation but the process doesn’t involve trying
  • N.S. involves genetic variation + selection among variants present in a population

Within our lifetime, we can’t adapt in our own bodies

= we are byproducts of our parents environment and thus, have adapted to their environment

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20
Q

Standing genetic variation
and “willing a trait”

A
  • if there is no genetics for a trait it can’t be “willed” into existence
  • must exist from the beginning
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21
Q

NS gives organisms what they need

A

Misconception!

  • NS has 0 intentions/senses; it can’t sense what a species needs

*therefore, what is good for a snake today is not the same as what is good 10 years from now. N.S. is just an outcome of selection and what works in a common environment**

  • If a population happens to have the good genetic variation, they’ll just survive better and leave behind fertile offspring {population evolves}
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22
Q

Selection acts for the good of the species

A

Misconception!

  • NS happens to individuals, what changes is populations
  • altruistic acts were a challenge for evolution
    (meaning helping another individual when it risks your own survival, such as alarm calling mammals)
    can be explain via kin selection
  • Selfish gene (Dawkins); genes drive traits that help them spread//genetic segments enhance their own transmission at the expense of other genes in genome
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23
Q

Further Misconceptions about evolution

A

1) selection acts on individuals, letting them evolve
- acts on individuals w/ particular good traits, but the only thing that changes is the makeup of population NOT THE INDIVIDUAL

singular human will only see evolution as a relative measure/comparison compared to others in your population

2) Evolution occurs slowly
- rate is controlled by several factors i.e. generation time (bacteria and viruses are fast)

3) N.S. is directed
- N.S. is actually mindless and mechanistic, and selects among whatever variations exist within the population
- therefore, there is no END GOAL or DIRECTION

4) Favourable traits arise in response to change in environment
- other way around, changes in environment allow individuals with favourable traits to flourish

5) Selection acts on genotype
- its based on the phenotype NOT THE UNDERLYING GENOTYPE

6) Humans stopped evolving
- Not true. i.e. protection against malaria and development, had of lactose intolerance

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24
Evidence regarding evolution
- "just a theory" - debates on how evolution took place - gaps in fossil records = work-in progress, might not have the exact lineage (which actually makes it look more believable) - continual refining of evolution (like all good sciences) - Darwinism is rejected bc he didn't know about genetics (which acc makes his theory stronger) - misconception: its not observable or testable (it is through CRISPR) - Animals: Guppies, Finches, Fruitflise, Sticklebacks {MODEL SYSTEMS}
25
CRISPR and EPIGENETICS
CRISPR: alter genotype to determine if its helps with fitness EPIGENETICS; change in phenotype by genotype INDIRECTLY
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why are humans not model systems
- we evolve slowly and have factors that affect evolution such as culture I.E. CULTURE AFFECTING EVOLUTION Spices, which have antimicrobial properties, may have helped humans adapt to warmer climates where food spoilage was more common
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Applications of Evolution
- antibiotic resistance in bacteria is a consequence of evolution by N.S.
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Implications + Applications of Evolution
- unifying theme for all life-sciences - medical applications (HIV, antibiotics, etc.) - global warming issues (breeding times; if breeding times is not optimal for food source then there becomes a genetic barrier for who opts in/out) - industrial applications (pesticides) = changes in spray formula so you're not selecting for 1 phenotype
29
Misuse of evolution
SOCIAL DARWINISM - "survival of the fittest": creates oppression of ppl - Division btwn evolution and religion; leads to immoral behaviour (animal like) - the mismeasure of man (by Stephen j. Gould)
30
What does descent with modification mean?
- all life on earth descended from a common ancestor and that all populations of organisms change over time
31
How long does it take a population to evolve?
over many generations
32
What does N.S. lead to?
adaptation and increased fitness
33
sexual selection
- from darwin - traits that help organisms reproduce (i..e colourful feathers on birds)
34
phelyogenetic tree
- from darwin - how related diff species are to each other
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Artificial Selection ad selective breeding
- certain traits can be inherited by offspring (taken advantage of by breeders) - humans (breeders) selectively breed for desired characteristics; enhancing those traits in future generations {selective breeding} Artificial Selection= human mediated evolution
36
Selective Breeding and Corn
- corn is originally from a Mexican grain (teosinte), but farmers selected the largest, easy to eat, and exposed kernels on teosinte which is how we got the corn we have today
37
Agents of Selection
- environmental factors: limited food + habitat, predation, competition, disease - individuals w/ heritable traits that provide an advantage in obtaining limited resources and avoiding predation/disease will have a better chance at reproducing and lead to population level changes - differences are created by differences in DNA and can be inherited = naturally selected advantage in their habitat
38
N.S. is dynamic
- what's fit now might not be in 5 years - depending on selection pressures
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fitness acts on all traits as a...
COMPOSITE - finding food - mating - survival - reproduction *not just based on 1 trait, several traits influence fitness*
40
Population
- group of interbreeding individuals of a species that live together in a specific place - individual organisms don't evolve in their life (we are byproducts of previous selective pressures), the unit upon which evolution acts (relative measure) is POPULATION
41
Evolution depends on differential survival and reproduction that comes from what 2 things?
1) variation amongst individuals in a population 2) heritability of that variation - i.e. there are some traits aren't genetic but are caused by environment such as orange fur caused by orange pigment in food
42
N.S. and Islands
Early evidence from Island population observations - each island= isolated habitat w/ conditions that are distinctly diff w/ diff selective pressures GALAPAGOS - prime example - four mockingbird species are all descended from a common ancestor but have adapted to diff environments (Darwin studied these not finches) theory: population of one mockingbird species came and colonized most of islands around the same time = proof for descent w/ modification (changed over time w/ diff selective pressures and w/ a common ancestor)
43
endemic
species found nowhere else on earth i.e. the mockingbirds Darwin studied - they are morphologically (body traits and types) distinct
44
adaptations
ADAPTATION: inherited aspects of an individual that make well suited to thrive in a particular environment - species experience diff environments leading to N.S. which favours diff traits differently depending on environment *predicted that species become better adapted to specific environments over time (such as the birds)* -- i.e. birds will adapt their songs to be more transmissible to mates depending on environments
45
Random Mutations Lead to Variation
- variation in DNA sequences gives rise to individuals within a population exhibiting different traits - DNA sequence of any individual may be different because of MUTATIONS MUTATIONS: random, heritable changes in DNA sequence - may come from errors in DNA replication, or agents
46
Standing Genetic Variation
- some individuals have mutations that may be sitting in 1 environment but become in a changing environment - from genome
47
What well-known examples of N.S. are there?
1) moth populations - predation pressure (birds being able to see white moths easier) and changing environments (industrial rvln) caused black moths to become dominant in population as they camouflaged better in their environment 2) red vs white salmon - sexual selection - in some populations, they prefer brighter red males *Found locus of gene that dictates if they'd be red/white: based on process carotenoids*
48
How might experimental evolution show support for N.S.?
- using organisms w/ short generation times can help us conduct studies - allowing for direct comparisons btwn ancestral and evolved populations i.e. E.COLI AND CHANGE IN TEMPERATURE - scientists wanted to determine if e.coli (for many generations) would adapt to a temperature that's lower than their og optimal? - they saw relative fitness was greater than 1= population (in 20-35 degrees) still grew faster than ancestral pop. so, the e.coli adapted but with even higher temperatures, the new generation did not do as well as ancestral generation (37-40 degrees)
49
functional genomics
- we can attribute the exact function to genome (displayed w/ Manhattan flock, dots=cause particular phenotype) example: fish losing armour - marine stickleback need armour based on their oceanic environments but freshwater ones don;t - specific functional genes (Pitx 1) can be linked to fitness-related traits (pelvic spines) = selection on transcription, freshwater sticklebacks don't produce Pitx1 bc its costly to produce armour, they have the gene though - no armour was preferred because less energy expenditure and dragonfly larvae (predator) in lakes prefer prominent spines - led to increased fitness
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generation time
- rate of change within a population is determined by GENERATION TIME (avg difference in age between a parent and its offspring)
51
Rosemary Grant
- made a space for women in evolution - studied Darwins finches on the islands= most important dataset in science
52
What are 2 of the earliest misconceptions when it comes to evolution?
1) acquired traits are inherited 2) fixed species (natural theology)
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who proposed the theory of evolution by N.S.? Were they the only person to have done so?
Darwin - not the only person; Wallace also did at the same time but by analyzing beetles
54
Whose writing were influentials in the development of the theory of evolution?
- aristotle - carolus linneaus - lamarck - ofc Darwin
55
The scale of nature
- Aristotle created a ladder like classification of nature: SCALA NATURAE = problem for evolutionary biology - because it gave perception that humans were the end-result and he had "lower-class animals" IMPACT: NATURAL THEOLOGY europeans had merged Aristotle's classification system w/ biblical account of creation to arrive at a view of the natural world where (1) organisms had been specially created by God (2) species could never change or become extinct (3) new species could never arise
56
What lines of evidence contributed to paving the path of evolution
- observations of patterns in organisms - geological evidence of earth - fossilized life similar to but distinct from modern organisms
57
Carolus Linnaeus'
- swedish botanist - classified all organisms via binomial species classification system (TAXONOMY; branch of biology that classifies organisms) - similar-looking organisms are grouped together and organized into broader, more inclusive categories *first one to actualize what Darwin was saying about biology*
58
Indigenous Peoples and their impact
- named plants, based on appearance and growth form of a plant + its use to humans I.E. soapberry - derived from word meaning to "froth" because its extracts can be whipped as froth
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Jean Baptiste de Lamarck
- French naturalist Perfect Principle: simple organisms evolved into more complex ones, moving up *scale of nature* - microscopic organisms were replaced by spontaneous generations, where simple forms of life were believed from arise non-living things - ACQUIRED TRAITS ARE INHERITED - characteristics acquired during and organisms lifetime can be passed on to future generations - i.e. giraffe would grow a longer and longer neck during its lifetime to get to trees and then pass those traits to its offspring
60
Why was Lamarck wrong
(1) Organisms do not appear through spontaneous generations (non-living things can't create life) (2) Although muscles can grow larger through continued use, organisms can't evolve fundamental physiological changes during their lifetime, and any physical changes acquired during an organisms life are not passed to offspring
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What was Lamarck right about
- species change over time
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Darwin's Voyage
in 1831 he went on a voyage around the world on HMS Beagle - primary purpose was to map the coast of South American
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another example of lamarcks wrong acquired trait hypothesis
- Lamarck believed that as wading birds stretched their legs keep their bodies while feeding, successive generations would have progressively longer legs
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Basis of Darwins Major Insights
major observations came from 3 observations of study: (1) Geology and fossil record (2) Geographic distribution of species (animals in Australia aren't the same in France) (3) comparative morphology of species (animals come from all diff parts of the world but still have similar elements) i.e. of (3) : African Ostrich has similar elements to Australian Emu and South American rhea
65
Darwin + Andes
- underwent earthquake in Chile - climbed up Andes and discovered fossil shells of marine organisms (indicated earth is rlly old and species CAN go extinct, some fossils looked nothing like living creatures, but others resembled living species (ex. glyptodonts and armadillos) = Lyell was right (published Principles of Geology): the geology of the Earth is not static; it changes over time - Darwin hypothesized that life can do the same
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extant vs extinct
extant: alive today extinct: gone today
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Biogeography
- studies of the worldwide distribution of plants and animals = biogeography - raised many q abt the number of species created abt God and where they'd fit on scale of nature
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Comparative Morphology
- Biologists began to compare morphology of organisms and discovered interesting similarities and differences I.E. human arm, flippers of seals, and wings of bats differ in size, shape, and function but have very similar underlying structure = LE COMTE DE BUFFON PROPOSED VESTIGIAL STRUCTURES
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vestigial structures
- useless parts observed today: must have functioned in ancestral organisms - Buffon proposed that some animal must have changed since creation
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Buffon's vs Darwins hypothesis on vestigial homologous structures
- Buffon proposed that some animal must have changed since creation - Darwin proposed that it was because all the organisms are related, they look similar because they are descendants of an ancestor they all shared (SHARED HOMOLOGY)
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Homology
- similarity present in a group of organisms - to Darwin, morphological similarities among species suggested common ancestry
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Non-Homolgus structures
- body-shape of sharks (fish) and orca whales (mammals) fish ≠ whales - both streamlined shapes, powerful tails, and short fine/flippers (same elements in diff forms) - homoplasty= opposite of homologous
73
More Vestigial structures examples
Kiwi: flightless, tiny useless wings - as it gets more ancient the wings would go away - wings are costly to produce, use that energy to survive (these kiwis outlive the other ones) Boa: tiny remnant hind limbs (spur) Humans: Goosebumps to make us look bigger with hairs sticking up
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Alfred Russel Wallace
- naturalist - arrived to similar conclusions as Darwin about species changing over time after extensive research on SE Asia - studied beetle specimen - Wallace conveyed his ideas about evolution to Darwin via letter, Darwin quickly put together *The Origin* after this, but kept Wallace's letter w/ it (Darwin's ideas were still more thorough)
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Influence of Thomas Malthus
- Thomas Malthus (political economist) - humanity was destined for disaster based on human pop. increases exponentially as gains in agriculture was steady - addressing declines in living conditions; birth rate needs to be controlled to avoid poverty and starvation INFLUENCE/IMPACT: - Darwin +. Wallace observed that the potential of species to reproduce is far greater than the number of offspring that reach adulthood - no species seems to reproduce to their full potential indicates that offspring are under constant "STRUGGLE FOR EXISTENCE" - organisms are in competition w. one another for limited food and other resources they have to escape predation and they have to survive often unfavourable environments
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Modern Synthesis
- unified theory of evolution - integrated data from biogeography, comparative morphology, comparative embryology, genetics, palaeontology, and taxonomy in an evolutionary framework - natural selection is the primary mechanism of evolution, but its not the only mechanism - change happens gradually, and mutations don't play as big a part in evolution as was once believed
77
Despite research and evidence, what misconceptions about evolutionary theory still persist?
- women are less evolved than men (from textbook) - N.S. is the primary mechanism of evolution BUT NOT THE ONLY ONE - change happens gradually, and mutations don't play as big a part in evolution as was believed
78
microevolution and macroevolution
microevolution: small-scale genetic changes that population undergo, often in response to shifting environmental circumstances (small evolutionary shift in size of the bill of finch) macroevolution: larger-scale evolutionary changes observed in species. Comes from gradual accumulation of microevolutionary changes.
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Darwins 4 Postulates
Postulate: conditions necessary to support a theory (1) Individuals within populations are variable for a particular trait (2) Variations among individuals are heritable, at least in part, passed from parents to offspring (3) In every generation, some individuals are more successful at surviving and reproducing than others (4) Survival and reproduction of individuals is NOT RANDOM If these are supported then... = Individuals with the most favourable variations (survival and reproduction) are naturally selected.
80
Semantics of N.S. | define darwianian fitness and adaptation
Darwinian Fitness- ability of an individual to survive and reproduce in its environment Adaptation: trait or characteristic that increases its fitness relative to those w/o trait. = Not every trait is adaptable, traits have 2 be tested
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Darwin's Finches
- complex of birds from central or South American common ancestor 2.3 MYA= mutations, DNA, and molecular clocks are used to date a common ancestor and its relation to species
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Case Study: Medium Ground Finches
- 1 species of Darwins Finches - good to study because: few of them migrated off/on; populations were easy to manage - each one has a unique band; identifiable - 4.5 years=generation time - primarily seed eaters (bigger beaks, larger seeds) MALES (black) VS FEMALES (beige) = sexually selected
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4 postulates and Finch Population 1/4
**(1) Is the finch population variable (variation in phenotype?)** -histograms show varying frequency of beak depth trait = yes, there is variation
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4 postulates and Finch Population 2/4
**(2) Is some of the variation heritable?** - heritability of a trait is defined as the proportion of variation observed in a population that is due to variation in genes (by definition, anything that's not genetic is due 2 the environment) BROAD-SENSE HERITABILITY EQN = VG/VP = VG/(VG+VE) VP= variation in population VG= variation due to genetics VE= variation due to environment - varies between 0 (all environment) and 1 (all genetics) FOR FINCHES: - line of best fit (minimize distance between on orthogonal (diagonal) scale) - strong relationship between parents and kids = heritable (for beak depth trait) *parent-offspring regression* SPECIFIC GENES RESPONSIBLE: - genetic basis of beak development - growth factors (embryonic stages) - bone morphogenic protein 4 (BMP4)=affects shape/size of beak larger beak (more of it = bigger beak) - use mRNA staining to look for it (fluorescence) - BMP4 and relative beak depth= strong relationship
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4 postulates and Finch Population 3/4
**(3) Variation in survival or reproduction?** - strong selection pressures alter the population/fitness of finches i.e. weather affecting food creating pressures over beak size - when seeds got larger and harder, environment selected for larger beaks that could open them (plants keep h2o to survive)
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4 postulates and Finch Population 4/4
**(4) Survival & Reproduction are non-random?** - 1/2mm shift showed that selection pressures favoured larger beaks (larger, tougher seeds) - as environment fluctuates and small, softer seeds become common, smaller beaks will be favourable again = as environment changes, selection pressures change
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How NS Operates
1) NS is not forward looking (no end-goal, just adapted to previous environment) 2) NS is nonrandom (but not progressive) - bullet in car analogy 3) Fitness is not circular - environment drives fitness - requirement: heritable variants do better than others, as opposed to random ones 4) Selection acts on individuals - not for the good a species -altruistic behaviours 5) NS acts on individuals 6) Traits need to be heritable (seen w/ regression line) - heritability estimate is high (steep line; will get into pop within 2-3 gens) or low (flat line; even w/ strong selection, won't permeate population fast) 7) New Traits can evolve - artificial selection w/ corn - big changes in short time due to strong selection pressure 8) NS doesn't lead to "perfection" - big body dilemma for fish
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Altruistic Behaviour
- if N.S. doesn't act for the good of a species? Altruistic Behaviour: helping someone at a cost to yourself/at your expense - happens because of kin selection (protect relatives w/ same genes) i.e. Prairie Dogs: alarm call could alert predators but it protects relatives, they will only do it with relatives
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big body fish dilemma
- big bodies are better for swimming away from predator= selected upon BUT - big body fishes have a large gonapodia, which hinders their swimming =CONCORDED TRAIT (big body and big gonapodias are tied together) = trade off w/ traits *multi-dimensional look at fitness* - there is a physical limit but no peak/perfection
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Original Roadblocks for Evolution
1) How was variability generated in populations - mutations (chromosomes, locus, alleles) 2) How were "variations" passed onto offspring - heritable via DNA 3) Age of the earth (Lord Kelvin's Calculations) - earth is very old: geological evidence of evolution
91
alternate definition for modern synthesis
integrating genetics w/ Darwins 4 postulates
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Redefining Darwins 4 postulates
1) As a result of mutation creating new alleles, segregation, independent assortment, and shuffling alleles into new combinations, individuals within populations are variable for many traits 2) Individuals pass their alleles to their offspring intact (1 locus w/ 2 alleles and you either get A or B allele) 3) NO CHANGE; In every generation, some individuals are more successful at surviving and reproducing than others 4) The individuals that survive and reproduce are those w/ the alleles (or combinations of alleles) that best adapt them to their environment
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Additive vs Non-Additive Genetic Effect
Additive genetic effects involve independent contributions of alleles to a trait, while non-additive effects arise from interactions where alleles influence each other’s expression.