Chapter 16 Drug Transport

Question 1

A method of delivering drugs to a target tissue where complete absorption is possible but may not have 100% action

Answer 1

Intravenous

Question 2

A method of delivering drugs to a target tissue where there is varying absorption and will likely not be 100%

Answer 2

Ingestion

Question 3

Most drugs use the _________system to move throughout the body though some can be ________ directly into the site of action

Answer 3

circulatory system

injected

Question 4

The BBB is does not block any transport to neural tissues T or F

Answer 4

False the BBB can block some transport to neural tissues

Question 5

What protein in the BBB is responsible for the special tight junctions

Answer 5

occludin

Question 6

What are SLCs

Answer 6

Solute carrier drug transporters

Question 7

Many subtypes/families of SLCs can be used to transport both xenobiotic and non-xenobiotic drugs T or F

Answer 7

True

Question 8

What are ABCs

what type of transport do they use

Answer 8

ATP Binding Cassette drug transporters

Use primary active transport

Question 9

ABCs and SLCs both transport mostly out of cells T or F

Answer 9

False - ABCs transport out of cells but SLCs transport IN TO cells

Question 10

Which transport system can create daughter cells that retain a state in which expression of the transport protein is upregulated in response to the presence of cell death inducing chemicals/drugs

Answer 10

ABCB1

Question 11

What are the three ways to get around MDR

Answer 11

Engagement (plug up the transporter)
Evasion (don’t use the transporter use something els)
Exploitation (just beat the hell out of it so the cell makes more of it)