Chapter 1. Stem Cells Flashcards

1
Q

What are 4 specific types of stem cells

A
  1. Totipotent
  2. Pluripotent
  3. Multipotent
  4. Unipotent
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2
Q

What is the general concept of stem cells (list 3ex)

A
  1. Stem cells can self renew
  2. They are cells that can develop into the whole organism
  3. They can generate daughter cells that can differentiate into many specialized cells
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3
Q

what type of cells can develop into the whole organism

A

totipotent stem cells

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4
Q

what type of cells can develop into all cell types of the body (minus supporting structures)

A

pluripotent stem cells

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5
Q

what type of cells can develop into a smaller number of specialized cells

A

multipotent stem cells

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6
Q

what type of cells can develop into a single cell type

A

unipotent stem cells

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7
Q

What type of stem cells are present in the blastocyst stage of development

A

Multipotent

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8
Q

What type of stem cells are present in the 8 cell stage of development

A

pluripotnent

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9
Q

Define plasticity

A

The ability to differentiate into many cells types

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10
Q

Name 4 types of multipotent stem cells

A
  1. Hematopoeitic
  2. Skin
  3. Neural
  4. Epithelial
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11
Q

The ________ stem cell is a type of multipotent stem cell found in adults

A

mesenchymal

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12
Q

What adult stem cell is originally found in bone marrow

A

mesenchymal

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13
Q

The mesenchymal stem cell can be found in what 7 locations

A
  1. adipose tissue
  2. nervous system
  3. skin
  4. tendon
  5. ligament
  6. synovial membranes
  7. trabecular bone
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14
Q

These adult stem cells can give rise to:

  1. osteoblasts
  2. Chondrocytes
  3. adipocytes
  4. Other connective tissue
A

mesenchymal

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15
Q

What type of stem cell renewal gives rise to two stem cell daughter cells

A

symmetric cell division

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16
Q

What type of stem cell renewal gives rise to two differentiated daughter cells

A

symmetric cell division

17
Q

What type of stem cell renewal gives rise to a stem cell daughter cell and a differentiated daughter cell

A

asymmetric cell division

18
Q

Dysregulation of what type of stem cell renewal can lead to cancer

A

asymmetric

19
Q

What is the stem cell niche (3 bullet points)

A
  • Microenvironment that controls stem cell self renewal
  • Prevents stem cells from becoming depleted or overproduced
  • controlled by extrinsic and intrinsic signaling
20
Q

what does IPS stand for and what is it

A

Induced pluripotent stemcell, a cell that returns/is reprogrammed to its pluripotent state through induction of genes that encode for specific transcription factors