chapter 16 - brain and cranial nerves Flashcards
• brain consists of
the brainstem (medulla oblongata, pons, mesencephalon), cerebellum, diencephalon (epithalamus, thalamus, hypothalamus), and cerebrum
• cortex
= grey matter located on the surface of the cerebrum and cerebellum
• nuclei
deep clusters of grey matter surrounded by white matter
• extremely delicate – requires protection provided by:
o bony skull
o cranial meninges
o cerebrospinal fluid
o blood-brain barrier
Ventricles
• cavities and tubes lined with ependymal cells and filled with cerebrospinal fluid
• lateral ventricles
relatively large cavities – one within each hemisphere of cerebrum
o connected to third ventricle by interventricular foramen
• third ventricle
small cavity in center of diencephalon between two halves of thalamus
o cerebral aqueduct – slender canal that passes through mesencephalon and connects third ventricle to fourth ventricle
• fourth ventricle
= begins between pons and cerebellum to superior portion of medulla oblongata
o continuous with subarachnoid space
o inferior part of medulla oblongata narrows and continues into spinal cord as central canal
• hydrocephalus
blockage of cerebral aqueduct or fourth ventricle
o blocked at time of birth or due to encephalitis (brain infection), meningitis (infection of meninges covering brain), trauma, and tumors affecting brainstem
o production of CSF continues but blocked exits cause increased intracranial pressure
if skull bones not completely ossified – pressure may severely enlarge the head
compresses blood vessels, dilates ventricles and compresses of nervous tissue resulting in irreversible brain damage
o treated successfully by placing shunt (drainage tube) between ventricles and abdominal cavity
Cranial Meninges
surround brain and continuous with spinal meninges
• epithelial and connective tissue membranes that protect brain – acting as shock absorbers and preventing contact with skull bones
• dura mater
dense irregular fibrous connective tissue
o thickest and most superficial
o two layers - adhere tightly to cranial bones
periosteal cranial dura = outermost layer – fused to periosteum of cranial bones
meningeal cranial dura = inner layer that is continuous with dura mater of spinal cord
o dural sinuses
= spaces formed where two layers of dura mater are separated from each other
lined with endothelium and transport venous blood and cerebrospinal fluid
all veins draining blood from brain empty in dural sinuses that then drain into internal jugular veins
o meningeal cranial dural folds
partitions that extend into major brain fissures
falx cerebri (Fig 16.3, 16.5) = lies within longitudinal fissure and anchors anteriorly to crista galla of ethmoid bone
o subdural space
between opposing epithelial of dura and arachnoid mater and contains small amount of serous fluid
• arachnoid mater
middle thin and wispy layer
o subarachnoid space (Fig 16.5) = network of collagen and elastin fibers between arachnoid and pia maters
contains blood vessels and cerebrospinal fluid
• pia mater
deepest layer tightly bound to surface of brain
o anchored to surface of brain by processes of astrocytes
Cerebral Spinal Fluid (CSF
- clear fluid similar to blood serum with most of proteins removed
- provides protective cushion around CNS and allows brain to float within cranial cavity
- provides some nutrients to CNS tissues
cerebral spinal fluid produce by ?
choroid plexus : specialized ependymal cells, support tissue and capillaries
o formed by invaginations of pia mater into roof of ventricles and covered by ependymal (special epithelial) cells
o ependymal cells secrete Na+ into ventricles and water follows by osmosis
o tight junctions between cells forming barrier
substances do not pass between cells but must be transported across cells
cerebral spinal fluid fills…
• fills ventricles, subarachnoid space and central canal of spinal cord (Fig 16.7)
o some drains into dura sinuses to be removed by venous circulation
blood supply to brain
- brain has high metabolic rate and brain neurons not capable of storing high-energy molecules (glycogen)
- requires large, constant blood flow for oxygen and glucose delivery
- receives 15-20% of blood pumped by heart
- interruption of blood flow for seconds can cause unconsciousness – for minutes = irreversible brain damage
blood supply to brain via :
o internal carotid arteries (Fig 22.12) – enter via carotid canals (temporal bones)
o vertebral arteries – enter via foramen magnum
join to form basilar artery
o cerebral arterial circle (Circle of Willis) (Fig 22.13) = contributions from basilar artery and internal carotid arteries
anterior, middle and posterior cerebral arteries = branches that supply cortex
what is a brainstem ?
• connects the spinal cord to the brain
• contains three anatomical subdivisions (inferior to superior):
o medulla oblongata, pons, and mesencephalon (midbrain)
• and one functional unit – the reticular formation that spans all three anatomical divisions
• contains many reflex centers essential for survival
medulla oblongata
most inferior (caudal) portion of brain
o contains sensory and motor tracts
pyramids – prominent enlargements on anterior surface
• contain large descending motor tracts controlling skeletal muscle
cranial nerve nuclei
= clusters of grey matter composed mostly of neuron cell bodies
olivary nuclei
– protrude from anterior surface lateral and superior to pyramids
• nuclei involved in balance, coordination, and modulation of sound from inner ear
• relays information to the cerebellar cortex
part of cranial nerve nuclei
brainstem stem serve as
serve as centers for vital reflexes
• cardiovascular centers – regulating heart rate and blood vessel diameter
• respiratory centers – rate and depth of breathing, coughing, sneezing
nuclei for cranial nerves
VIIl, IX, X, XI, and XII
• pons
– connects brainstem to the cerebellum by cerebellar peduncles
o nuclei for cranial nerves V, VI, VII and VIII
o sleep center that initiates REM (rapid eye movement) sleep
• mesencephalon
contains nuclei for cranial nerves III, and IV
o four sensory nuclei form mounds on dorsal surface = corpora quadrigemina
superior colliculi
– receive sensory input from visual, auditory and tactile sensory systems
• involved in reflex movements of head, eyes and body toward stimulus
o “startle reflex”, loud noise, bright light, acute pain
part of mesencephalon
inferior colliculi
– involved in hearing
part of mesencephalon
o red nucleus
(appears pink due to blood flow) aids in unconscious regulation and coordination of motor activities
part of mesencephalon
o substantia nigra
appears dark due to melanin granules) part of the basal nuclei system
involved in maintaining muscle tone and coordinating movement
• reticular formation
diffuse system of nuclei scattered throughout length of brainstem
o receives axons from large number of sources
o modulates and controls many functions of the brainstem
o controls state of alertness and consciousness – including sleep-wake cycle
Cerebellum
• three parts:
o cerebellar hemispheres (2) – participates with cerebral cortex to plan, practice, smooth and coordinate limb and trunk movements
divided by primary fissure into anterior and posterior lobes
o vermis = narrow central portion
together with medial portion of hemispheres control posture, and allow smooth flowing movements
o flocculonodular lobe = small lobe – lies inferior and anterior to hemispheres – helps control balance and eye movements
• grey matter- cerebellum
o on cortex (surface) – has ridges called folia
contains several cell types (neurons): stellate, basket, granule, Golgi, and Purkinje
• Purkinje cells – largest, inhibitory and only cortical neurons that send axons to the cerebellar nuclei
mossy fibers = afferent axons that branch extensively within cerebellum
o and in deep cerebellar nuclei surrounded by white matter
• white matter
location
in medulla – resembles branching tree = arbor vitae
• cerebellar peduncles
) link the cerebellum to the posterior portion of the brainstem
• ataxia
= loss of muscle coordination in the arms or legs due to cerebellar dysfunction
Diencephalon
- between brainstem and cerebrum
* contains: epithalamus, thalamus, and hypothalamus
• epithalamus
roof of third ventricle and is superior and posterior to thalamus
o contains: pineal gland – secretes melatonin
action not completely understood – modulation of biorhythms and sleep-wake cycle
• thalamus
largest part with two lateral portions connected in center
o surrounds third ventricle of brain
o receives all sensory input
synapse in thalamus then relayed to appropriate areas of cerebral cortex (Table 16.5)
anterior nuclei – part of limbic system – role in emotions, memory and learning
medial nuclei – provide conscious awareness of emotional states
ventral nuclei
• ventral lateral and ventral anterior relay information to and from basal nuclei, cerebellum and cerebral cortex that allow formation and fine tuning of movement plans
• ventral posterior
relays touch, pain, temperature and proprioceptive information to the primary somatosensory cortex of the parietal lobe
posterior nuclei
– contains two sets of nuclei: pulvinar and geniculate nuclei
• pulvinar nuclei – project sensory input to association areas of the cerebral cortex
• medial geniculate nucleus – receives auditory information
• lateral geniculate nucleus – receives visual information