Chapter 16 Flashcards
Cell division
Reproduction of cells
2 types of cell division
Mitosis
Meiosis
Cytogenetic
Find of genetics involving microscopic examination of chromosomes & cell division
Karyotype
Reveals number, size, & form of chromosomes in an actively dividing cell
How many pairs of chromosomes in human
23
Total howmany chromosomes in human
46
How many sex chromosomes in human
1 pair
How many autonomies in human
22 pair
Diploid or 2n
Humans have 23 pairs of chromosomes
Haploid or N
Gametes have 1 member of each pair of chromosomes or 23 total chromosomes
Cell cycle
Sequence of event/phases resulting in 2 daughter cells
G1
First gap
S
Synthesis/copy of DNA
G2
Second gap
M
Mitosis & cytokinesis
G0
Substitute for g1 for cells postponing division of never dividing again
G1 Interphase
Cell accumulates molecular changes that cause progression through the cell cycle
Phase restriction point for g1 interphase
Where cell committed to enter phase
S interphase
Chromosomes replicate, & after replication 2 copies stay joined to each other & ape called sister chromatids
What comes after S
G2
How many chromatids in g2
92 total/46 pairs
G2 interpahse
Cell synthesizes proteins needed during mitosis & cytokinesis
M phase - mitosis
Divide 1 cell nucleus into 2
Cytokinesis
Division of cytoplasm,
Decision to divide relies
External factors
Internal factors
External factors
Environmental condition
Internal factors
Cell cycle control molecules
Cell cycle Control
Cyclins or cyclin- dependent kinases
3 critical regulatory checkpoints
G1 checkpoint
G2 check point
Metaphase checkpoint
G1 checkpoint
Senses DNA damage, conditions favorable for division
G2 checkpoint
Senses DNA damage, proper replication, proteins for transition to M are present
Metaphase checkpoint
Integrity of spindle apparats (chromosome sorting)
Mitotic cell division
A cell divides to produce 2 new cell genetically identical to the original
What is original cell called
Mother cells.
What is new cells are called?,
Daughter cells.
Mitotic cell division involves
Mitosis & cytokinesis
Preparation for cell division
DNA replicated
Sister chromatids
Tightly associates at centromere
Serves as attachment site for kinetochore used in sorting chromosome
Mitotic
Sorting process ensures that eac daughter cen will obtain the correct number & types of chromosomes
Mitotic spindle apparatus (mitotic spindle)
Responsible for organizing& sorting the chromosomes during mitosis
Centrosames
Microtubule organizing center (mtocs)
Centrioles
Found in centrosomes of animal cell.
Spindle microtubules.
Spindle ironed from microtubules
3 types of microtubules
Astral
Polar
Kinetochore
Astral
Position spindle apparatus in cell
Polar
Separate 2 poles
Kinetochore tubules
Attached to kinetochore bound to centromeres of each chromosome
Interphase
Phase of the cell cycle during which the chromosomes are decondensed & found in the nucleus (g1,s,g2)
Mitosis phases
Prophase
Prometaphase
Metaphase
Anaphase
Telophase
Prophase
Chromosomes have already replicated to produce 12 chromatids, joined as six pairs of sister chromatids
Prometaphase
Nuclear envelope completely fragments
Mitatic spindle is fully formed in this phase
Metaphase
Pair of sister chromatids are aligned along a plane halfway between the poles called the metaphase plate
Organized in a single row
Anaphase
Connections between the pairs of sister chromatids are broken
Telophase
Chromosomes have reached their respects poles & decondense
Nuclear membranes re-form to produce 2 separate nuclei
Cytokinesis
2 nuclei are segregated into separate daughter cell
Different in animal & plant
Cytokinesis in animals
Cleavage furrow constricts like a drawstring to separate the cells.
Cytokinesis in plant.
Cell plate forms A cell wall between the 2 daughter cell.
Sexual reproduction requires what
A fertilization event where haploid gametes unite & creat a diploid cell called a zygote
Meiosis
The process by which haploid cells (gametes) are produced from a cell that wasoriginally diploid.
2 differences at beginning of meiosis
Homologous pairs form a bivalent or tetrad
Crossing over.
Bivalent or tetrad
Homologous pairs of sister chromatids associate with each other, lying side by side to form a bivalent of tetrad.
Synaptonemal complex
Proteins join homologous chromosomes
Crossing over
Physical exchange between chromosome pieces ot the bivalent
Chiasma
Arm of the chromosome tend to separate but remain adhered at this crossover site
Prophase I
Replicated chromosomes condense & bivalents form as the nuclear membrane breaks down
Prometaphase I
Spindle apparatus complete, & the chromatids are attacked to kinetochore microtubules
Metaphase I
Bivalent organized along metaphase plate as double row
Anaphase I
Segregation of homologues occurs
Telophase I
Sister chromatids have reached their respective poles & decondense & nuclear membranes reform
Meiosis ii
Same sorting steps as in mitosis, no S phase between meiosis I & meiosis ii
When does sister chromatids separates in meiosis ii
During anaphase ii unlike a anaphase I
Chromosomal mutations
Deletions
Duplications
Inversions
Translocations
Deletions
Segment missing
Duplications
Section occurs 2/ more times in a row
Inversion
Change in direction along a single chromosome
Translocations
One segment becomes attached to another chromosome
Changes in chromosome number
Euploid
Polyploid
Euploid
Chromosome # that is viewed as the normal #
Polyploid
3/ more sets of chromosomes
N refers to what?
A set of chromosomes
Diploid
2n
Tripled
3n
Tetraploid
4n
Aneuploidy
Alteration # of particular chromosomes
Total # not an exact multiple of a set
Trisomic
Normal 2 copies of a chromosome plus a 3rd, 2n+1
Monatomic
Missing 1 of normal copies of a chromosome,2n-1
Nondisjunction
Chromosomes do not sort properly during cell division