Chapter 15a Flashcards
The principal activity of an antibody is to
unite with, immobilize, call attention to, or neutralize the antigen for which it was formed
Opsonin antibody stimulates opsonization:
microbes or other particles are coated with specific antibody so they will be more readily recognized by phagocytes
Antibodies can aggregate or agglutinate antigens by
cross-linking cells into clumps
neutralization
antibody reacting with complement
antibodies fill the surface receptors on a virus or the active site on a molecule in order to
prevent it from functioning normally
Are all antibodies protective?
No, some cause disease
Antisera
Most are polyclonal - they contain a mixture of antibodies with multiple specificities derived from several clones
Monoclonal antibodies
Have 100% precision
Originate from a single clone
Have single specificity
_____ are used in hybridization of cancer cells and plasma cells in vitro
monoclonal antibodies
Myelomas
- identical plasma cells
- cancer cells in bone marrow
- divide indefinitely
Hybridoma
fuse myeloma cell with normal plasma cell
Hybridomas are
immortal
Hybridomas are used in
research as a standard tool and help to expand disease diagnosis and treatment
Natural or Acquired immunity
acquired as part of normal life experiences
from breast milk and placenta
not involving medical intervention
Artificial immunity
through immunizations
