Chapter 15 Immunity Flashcards
Antigen
any molecule that stimulates an immune response
Innate/Nonspecific Response
Born with this system, consists of physical barriers, WBC, inflammatory response (histamine), chemicals
Inferferons
released by infected cells to warn other body cells and activate WBC in the area
Specific/Acquired Immunity
Takes over if Innate/Nonspecific response doesn’t fix it
Antigen Presenting Cells
APC
Macrophages
Dendric cells
B lymphocytes
3 Major histocompatibility complexes
MHC 1 - self antigen, RBC
MHC 2 - all APC
MHC 3 - genes that code for complement that aids immune response
Function of Macrophage
Carries antigen to T Helper lymphocyte in a lymph node
T Helper Cells
Activate other lymphocytes
T Suppressor Cells
manage the immune response
B Cells
make antibodies that float and plasma and attach to antigens there
Memory cells
Transport antigen information to other lymph nodes in case pathogen comes back, it will be recognized
Opsonization
allows macrophages to phagocytose the antigen
Neutralization
surround viruses and exotoxins
Agglutination
take cells out of circulation
Precipitation
take smaller molecules out of circulation
5 Classes of antibodies/immunoglobulins
IgM - first, forms pentamer
IgG - second, in response to an infection, monomer, crosses placenta
IgA - mucus membranes
IgE - binds to mast cells, allergies and parasites
IgD - binds to B Cells
Antibody titer
a test that serially dilutes plasma to determine the highest dilution a sample reacts to a reagent.
Natural Active Immunity
Natural Passive Immunity
Get an illness
Mother’s milk
Artificial Active Immunity
Artificial Passive Immunity
vaccination
get another’s serum and antibodies
Antitoxin serum
artificial passive, antibodies that neutralize toxins, exotoxins
Attenuated vaccines
Live cells/viruses, better immune response, may mutate back into virulent form
Inactivated vaccines
Dead cells/viruses, safer, may need many booster
Herd Immunity
Collective immunity through mass vaccination offers indirect protection for immunocomp. individuals