Chapter 15 - Diabetes Mellitus Flashcards
What is Diabetes Mellitus?
Relative or complete lack of insulin secretion by beta cells
OR
defects of insulin receptors
Diabetes Mellitus results in what?
disturbances of carbohydrate, protein, and lipid metabolism, and in elevated blood glucose levels
In Diabetes Mellitus, __________ and ____________ damage results in disability and premature death?
Macrovascular and Microvascular
Macrovascular complications?
- coronary artery disease
- peripheral vascular disease
- cerebrovascular disease
Microvascular complications?
- nephropathy
- retinopathy
- neuropathy
- impaired healing leading to gangrene and amputation
Autonomic effects of Diabetes Mellitus?
- orthostatic hypotension
- gastroparesis
- neurogenic bladder
- impotence
Classifications of Diabetes Mellitus?
Type 1 (T1DM) : 5% to 10% of patients Type 2 (T2DM) : more than 90% of patients
Symptoms of Type 1 Diabetes Mellitus?
- polydipsia
- polyuria
- polyphasic
- weight loss
Type 1 Diabetes Mellitus is caused by what?
destruction of pancreatic beta cells
- Autoimmune disorder
- Idiopathic diabetes
Symptoms of Diabetes Mellitus?
- gradual onset of polyuria and polydipsia
- easily fatigues
- frequent infections (especially UTIs)
- May have condition for many years before complications lead to diagnosis
What is Type 2 Diabetes Mellitus caused by?
Insulin resistance - failure of cells to respond to insulin
OR
- defects in insulin secretion
Type 2 Diabetes Mellitus Risk Factors?
- family history
- obesity
- gestational diabetes
________ produces an insulin-resistant state; causes cells to produce excess insulin
Obesity
What is A1C called?
Glycosylated hemoglobin
What does A1C reflect?
Reflects blood glucose control for 100 to 120 days